| Tclin | Interleukin-17 receptor A |
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Brain Ischemia | 110 | 0.0 | 0.0 |
| IMMUNODEFICIENCY 51 | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Plaque psoriasis | 17 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 6.8e-25 |
| Astrocytoma, Pilocytic | 3081 | 1.6e-08 |
| ovarian cancer | 8520 | 5.6e-06 |
| hepatocellular carcinoma | 547 | 3.0e-05 |
| pediatric high grade glioma | 1064 | 4.0e-05 |
| glioblastoma | 5792 | 1.6e-04 |
| osteosarcoma | 7950 | 4.1e-04 |
| tuberculosis | 2010 | 5.0e-04 |
| pituitary cancer | 1972 | 1.9e-03 |
| astrocytoma | 1146 | 3.8e-03 |
| pancreatic carcinoma | 562 | 5.5e-03 |
| pancreatic cancer | 2398 | 5.5e-03 |
| group 3 medulloblastoma | 4104 | 6.4e-03 |
| Disease | Target Count |
|---|---|
| Candidiasis, Familial, 5 | 1 |
| chronic mucocutaneous candidiasis | 7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.300 | 3.8e-03 |
| Astrocytoma, Pilocytic | 1.400 | 1.6e-08 |
| glioblastoma | 1.300 | 1.6e-04 |
| group 3 medulloblastoma | -1.200 | 6.4e-03 |
| hepatocellular carcinoma | 1.200 | 3.0e-05 |
| lung carcinoma | -1.500 | 6.8e-25 |
| osteosarcoma | -1.782 | 4.1e-04 |
| ovarian cancer | 1.400 | 5.6e-06 |
| pancreatic cancer | 1.200 | 5.5e-03 |
| pancreatic carcinoma | 1.200 | 5.5e-03 |
| pediatric high grade glioma | 1.100 | 4.0e-05 |
| pituitary cancer | -1.200 | 1.9e-03 |
| tuberculosis | 1.500 | 5.0e-04 |
| Accession | Q96F46 O43844 Q20WK1 IL-17 receptor A |
| Symbols |
CD217 IL17R IMD51 CANDF5 CDw217 IL-17RA hIL-17R |
ACAD11
DYNC2H1
IQGAP3
KIAA1671
SMG8
RPS6KA3
RPS6KA2
RPS6KA1
MAP7D2
ZNF318
ICE2
FAM208A
YEATS2
RICTOR
NCOR1
BCOR
PPIP5K2
BRIP1
HTT
TUBA4A
DDX11
DDX11L8
MCM8
CCDC88A
LRIF1
CBWD1
SIMC1
PLCH1
TUBB1
EIF4E2
ZBTB33
GTSE1
ZNF644
ANKHD1
NR3C1
ESPL1
TBL1XR1
TBL1X
HASPIN
BCAS3
TTF2
HDAC3
ZNHIT6
KIAA0586
C5orf34
USP54
TRPS1
MAP7
HAUS5
MKS1
TBCD
C15orf39
TEDC1
SIK2
PLEKHA5
PKN3
MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTP 1 - 70 SSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHR 71 - 140 RWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVE 141 - 210 TLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQ 211 - 280 VQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGP 281 - 350 GSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAI 351 - 420 SEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDF 421 - 490 KRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLR 491 - 560 SPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQ 561 - 630 ACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEG 631 - 700 EACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSR 701 - 770 PAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQ 771 - 840 RQLLFRQLQKNSGWDTMGSESEGPSA 841 - 866 //
