Tbio IL15RA Interleukin-15 receptor subunit alpha

Protein Summary

Description

High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK. This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q13261
• B4E2C2
• Q3B769
• Q5JVA1
• Q5JVA2
• Q5JVA4
• Q6B0J2
• Q7LDR4
• Q7Z609
• IL-15 receptor subunit alpha

Gene Name

• IL15RA

Ensembl ID

• ENST00000379971
• ENSP00000369306
• ENSG00000134470
• ENST00000379977
• ENSP00000369312
• ENST00000397250
• ENSP00000380422
• ENST00000397255
• ENSP00000380426
• ENST00000525219
• ENSP00000431529
• ENST00000528354
• ENSP00000435454
• ENST00000530685
• ENSP00000435995

Symbol

• CD215

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
PubMedID	0.95
biological term	0.7
disease	0.66
transcription factor binding site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.47   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 426   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.47   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0