Tbio IL11 Interleukin-11

Protein Summary

Description

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• P20809
• B4DQV5
• Q96EB4
• IL-11

Gene Name

• IL11

Ensembl ID

• ENST00000264563
• ENSP00000264563
• ENSG00000095752
• ENST00000585513
• ENSP00000467355
• ENST00000590625
• ENSP00000465705

Symbol

• AGIF
• IL-11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.88
gene perturbation	0.86
biological process	0.82
microRNA	0.68
PubMedID	0.66

Protein Classes

DTO Classes

Interleukin-11 Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1084.41   (req: < 5)

Gene RIFs: 178   (req: <= 3)

Antibodies: 423   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1084.41   (req: >= 5)

Gene RIFs: 178   (req: > 3)

Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0