Tchem | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Comments
Disease | Target Count |
---|---|
Major Depressive Disorder | 301 |
Unipolar Depression | 250 |
CHEMBL3687168
pIC50 7.57
CHEMBL220090
pIC50 7.60
CHEMBL3687155
pIC50 7.60
CHEMBL3687133
pIC50 7.60
CHEMBL3687182
pIC50 7.60
CHEMBL3687180
pIC50 7.60
CHEMBL2011933
pIC50 7.68
CHEMBL3682432
pIC50 7.68
CHEMBL3687178
pIC50 7.68
CHEMBL3687158
pIC50 7.68
CHEMBL3687148
pIC50 7.70
CHEMBL2011934
pIC50 7.70
CHEMBL3687176
pIC50 7.75
CHEMBL3687124
pIC50 7.75
CHEMBL2011941
pIC50 7.77
CHEMBL3687151
pIC50 7.82
CHEMBL3687183
pIC50 7.82
CHEMBL475251
pKd 7.89
CHEMBL3687160
pIC50 7.89
CHEMBL3682433
pIC50 7.92
MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKL 1 - 70 FAVEETGGSRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGN 71 - 140 IMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVT 141 - 210 LYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPI 211 - 280 LANILEVEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQ 281 - 350 EYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPKFVPKVDLQADYNTAKGVLG 351 - 420 AGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELK 421 - 490 AAAELRSRLRTLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKS 491 - 560 RMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKYQASLVTHGKRMRVVHETRNHLRLVGCSVAA 561 - 630 CNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDN 631 - 700 NRIIERLNRVPAPPDV 701 - 716 //