Property Summary

NCBI Gene PubMed Count 26
PubMed Score 228.68

Knowledge Summary

Patent

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TINX Plot

  Disease (1)

Disease Target Count Z-score Confidence
Lymphoma 57 4.251 2.1
Amebiasis 22 3.54 1.8
Leukemia 88 3.281 1.6

Protein-protein Interaction (4)

Gene RIF (2)

PMID Text
23303672 The human Iglambda locus is isolated intact as an ~300-kilobase yeast artificial chromosome (YAC) and also fully inserted into a rat chromosome.
12077254 New sequencing data show that the Mcg-Ke+Oz- isotype is encoded by a polymorphic C lambda 2 gene segment that differs from the normal J-C lambda 2 region at a single nucleotide position.

AA Sequence

GQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASS      1 - 70
YLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS                                       71 - 106
//

Text Mined References (27)

PMID Year Title
25946035 2015 Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.
23580065 2013 Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23303672 2013 High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Ig?/Ig? loci bearing the rat CH region.
22664934 2012 Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
22516433 2012 Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
16502470 2006 Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
15174051 2004 An investigation into the human serum "interactome".
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12077254 2002 Unraveling of the polymorphic C lambda 2-C lambda 3 amplification and the Ke+Oz- polymorphism in the human Ig lambda locus.
11955599 2002 Recognition of immunoglobulins by Fcgamma receptors.
9530559 1998 Three-dimensional structure of a human Fab with high affinity for tetanus toxoid.
9074928 1997 One-megabase sequence analysis of the human immunoglobulin lambda gene locus.
7737190 1995 Characterization of the two unique human anti-flavin monoclonal immunoglobulins.
6404900 1983 Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup.
6273747 1981 Clustered arrangement of immunoglobulin lambda constant region genes in man.
5549568 1971 [Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation].
4909564 1970 The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges.
4883841 1968 Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein.
4814727 1974 Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New).
4415202 1974 Primary structure of the Mcg lambda chain.
4215080 1974 The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-angstrom resolution.
3122211 1987 Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes.
2515285 1989 Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms.
2115572 1990 Structure and expression of the human immunoglobulin lambda genes.
814163 1976 Physicochemical and functional characterization of the C1r subunit of the first complement component.