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Tbio Insulin-like growth factor-binding protein 7

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

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Property Summary

NCBI Gene PubMed Count 119
PubMed Score 379.97
PubTator Score 526.32

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Cancer 2499 4.038 2.0
Kidney disease 430 3.034 1.5

Expression

  Differential Expression (33)

Disease log2 FC p
active Crohn's disease 1.885 2.5e-02
adult high grade glioma 1.300 4.4e-03
astrocytic glioma 1.600 5.8e-03
Astrocytoma, Pilocytic 1.500 1.5e-06
autosomal dominant Emery-Dreifuss muscul... 1.229 2.0e-02
Becker muscular dystrophy 1.118 3.1e-02
Breast cancer 2.100 1.2e-11
Common variable immunodeficiency -1.672 7.8e-05
cystic fibrosis -2.150 3.4e-07
dermatomyositis 1.700 1.1e-02
Down syndrome 1.200 2.9e-03
Duchenne muscular dystrophy 1.319 2.2e-08
ependymoma 1.800 6.5e-03
esophageal adenocarcinoma 1.600 4.3e-02
gastric carcinoma 1.900 1.2e-02
glioblastoma 1.100 8.2e-05
intraductal papillary-mucinous adenoma (... -2.800 6.5e-04
intraductal papillary-mucinous carcinoma... -3.200 2.2e-03
intraductal papillary-mucinous neoplasm ... -2.800 3.9e-03
juvenile dermatomyositis 1.485 7.4e-13
limb girdle muscular dystrophy 2A 1.118 1.6e-05
malignant mesothelioma -3.000 1.0e-08
oligodendroglioma 1.600 6.1e-03
ovarian cancer -2.800 2.6e-07
pancreatic cancer 1.900 1.9e-04
primary pancreatic ductal adenocarcinoma 1.735 4.8e-04
primary Sjogren syndrome 2.000 1.1e-02
psoriasis 1.400 8.1e-04
tuberculosis 1.400 1.2e-06
ulcerative colitis 2.000 1.8e-05
urothelial carcinoma 2.300 1.5e-07
Waldenstrons macroglobulinemia 2.426 3.1e-02
X-linked agammaglobulinemia -1.520 4.7e-02

Synonym

Accession Q16270 B4E1N2 B7Z9W7 Q07822 Q53YE6 Q9UCA8 IBP-7
Symbols AGM
PSF
TAF
FSTL2
IBP-7
MAC25
IGFBP-7
RAMSVPS
IGFBP-7v
IGFBPRP1

Gene

IGFBP7

  Ortholog (10)

Species Source Disease
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG

 UniProt Keyword (14)

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 GO Function (1)

 GO Component (5)

 GO Process (11)

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 Compartment GO Term (28)

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 MGI Phenotype (6)

 GWAS Trait (5)

 HCA RNA Cell Line (55)

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Pathway (11)

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Gene RIF (91)

AA Sequence 

MERPSLRALLLGAAGLLLLLLPLSSSSSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEP      1 - 70
CGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRA     71 - 140
ESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLP    141 - 210
GDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGA    211 - 280
EL                                                                        281 - 282
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Text Mined References (123)

PMID Year Title