Tbio IGFBP7 Insulin-like growth factor-binding protein 7

Protein Summary

Description

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q16270
• B4E1N2
• B7Z9W7
• Q07822
• Q53YE6
• Q9UCA8
• IBP-7

Gene Name

• IGFBP7

Ensembl ID

• ENST00000295666
• ENSP00000295666
• ENSG00000163453
• ENST00000514062
• ENSP00000486293

Symbol

• MAC25
• PSF
• AGM
• PSF
• TAF
• FSTL2
• IBP-7
• MAC25
• IGFBP-7
• RAMSVPS
• IGFBP-7v
• IGFBPRP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
protein domain	0.97
PubMedID	0.84
gene perturbation	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.29   (req: < 5)

Gene RIFs: 145   (req: <= 3)

Antibodies: 487   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.29   (req: >= 5)

Gene RIFs: 145   (req: > 3)

Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0