1. Home
  2. Targets
  3. cell adhesion molecule
  4. immunoglobulin receptor superfamily
  5. protein phosphatase
  6. Immunoglobulin superfamily DCC subclass member 4

Tdark Immunoglobulin superfamily DCC subclass member 4


 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 17.62
PubTator Score 1.97

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Premature ejaculation 16 4.342 2.2

Expression

  Differential Expression (17)

Disease log2 FC p
astrocytoma 1.100 4.1e-07
glioblastoma 1.700 1.6e-03
oligodendroglioma 1.100 1.2e-05
posterior fossa group A ependymoma 1.500 2.7e-04
group 3 medulloblastoma 2.600 1.2e-03
primitive neuroectodermal tumor 1.900 9.7e-04
Atopic dermatitis -1.500 2.4e-04
intraductal papillary-mucinous adenoma (... -1.200 4.5e-03
intraductal papillary-mucinous neoplasm ... -1.400 8.1e-03
pediatric high grade glioma 1.700 1.0e-03
pilocytic astrocytoma 1.200 7.1e-03
primary Sjogren syndrome 1.300 2.0e-03
psoriasis -1.300 2.1e-15
invasive ductal carcinoma -1.900 1.0e-03
gastric carcinoma 1.700 1.6e-02
ulcerative colitis 1.700 5.1e-04
ovarian cancer 1.500 1.8e-02

Synonym

Accession Q8TDY8 Q9HCE4
Symbols NOPE
DDM36

Gene

IGDCC4

PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

See all...

 GO Component (2)

 Compartment GO Term (12)

 HCA RNA Cell Line (35)

See all...

 CSPA Cell Line (2)

Pathway (1)

Gene RIF (1)

PMID Text
20658536 identified Nope as a novel oncofetal surface marker for murine and human HCC. Nope is specifically expressed by epithelial tumor cells but not in preneoplastic stages and is a promising marker

AA Sequence 

MARGDAGRGRGLLALTFCLLAARGELLLPQETTVELSCGVGPLQVILGPEQAAVLNCSLGAAAAGPPTRV      1 - 70
TWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLA     71 - 140
TLADFSLHPESQTVEENGTARFECHIEGLPAPIITWEKDQVTLPEEPRLIVLPNGVLQILDVQESDAGPY    141 - 210
RCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQ    211 - 280
DGKPISTDVIVLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRAS    281 - 350
TARFVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAAASL    351 - 420
AVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNVEYQFAVNNDTTELQV    421 - 490
RDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAPQLSLSSPNPSDIRVAWLPLPPSLSNGQVV    491 - 560
KYKIEYGLGKEDQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRTPSMHNQSHVP    561 - 630
FAPAELKVQAKMESLVVSWQPPPHPTQISGYKLYWREVGAEEEANGDRLPGGRGDQAWDVGPVRLKKKVK    631 - 700
QYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQRGPPLPPAHVHAESNSSTSIWLRW    701 - 770
KKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSSGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVER    771 - 840
STLPDRPSTPPSDLRLSPLTPSTVRLHWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEV    841 - 910
HGLESDTRYFFKMGARTEVGPGPFSRLQDVITLQEKLSDSLDMHSVTGIIVGVCLGLLCLLACMCAGLRR    911 - 980
SPHRESLPGLSSTATPGNPALYSRARLGPPSPPAAHELESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGV    981 - 1050
SEGRSHSKRKISWAQPSGLSWAGSWAGCELPQAGPRPALTRALLPPAGTGQTLLLQALVYDAIKGNGRKK   1051 - 1120
SPPACRNQVEAEVIVHSDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVGDPGQGAAWLDRELGGCELA   1121 - 1190
APGPDRLTCLPEAASASCSYPDLQPGEVLEETPGDSCQLKSPCPLGASPGLPRSPVSSSA             1191 - 1250
//

Text Mined References (7)

PMID Year Title
20658536 2011 Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma.
20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10997877 2000 Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
10708514 2000 Cloning and expression of nope, a new mouse gene of the immunoglobulin superfamily related to guidance receptors.