Property Summary

NCBI Gene PubMed Count 28
PubMed Score 46.54
PubTator Score 122.09

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (28)

Disease log2 FC p
systemic lupus erythematosus 1.500 1.2e-03
pancreatic cancer 1.500 3.9e-04
urothelial carcinoma -1.300 4.1e-02
malignant mesothelioma 1.100 1.2e-04
cutaneous lupus erythematosus 2.500 1.2e-04
astrocytoma 1.100 1.6e-07
osteosarcoma 2.836 1.3e-04
posterior fossa group A ependymoma 1.600 4.1e-05
glioblastoma 1.300 2.2e-02
group 4 medulloblastoma -1.600 9.4e-04
medulloblastoma, large-cell -2.100 4.2e-04
juvenile dermatomyositis 3.958 1.1e-14
lung cancer -2.700 3.9e-06
active Crohn's disease 1.647 1.0e-02
Multiple Sclerosis 2.600 8.3e-03
cystic fibrosis 1.800 1.1e-02
pediatric high grade glioma 1.300 9.8e-03
pilocytic astrocytoma 2.200 4.6e-07
primary Sjogren syndrome 2.100 1.0e-05
pancreatic carcinoma -1.300 1.4e-02
subependymal giant cell astrocytoma 2.661 9.0e-03
Breast cancer -1.300 1.0e-02
invasive ductal carcinoma 1.923 1.1e-02
nasopharyngeal carcinoma 1.600 1.4e-02
lung carcinoma -1.700 4.0e-11
progressive supranuclear palsy -1.100 3.0e-03
mucosa-associated lymphoid tissue lympho... 1.941 2.4e-02
acute myeloid leukemia 1.500 6.7e-03

Protein-protein Interaction (7)

Gene RIF (17)

PMID Text
26116899 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
25252956 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
25174799 Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor.
25170834 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
24742347 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
23867918 Data show that interferon-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.
22986528 IFIT2, a protein responsible for interferon stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker.
22825553 ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation.
22647704 HIV-1 Vpr upregulates the gene expression of IFIT2 in human monocyte-derived dendritic cells
22065572 Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
21190939 role of ISG54 in the induction of apoptosis via a mitochondrial pathway shedding new light on the mechanism by which IFN elicits anti-viral and anti-cancer effects
20506645 The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls.
18819931 IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma.
17030862 IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells.
16973618 We observed that, although double-stranded RNA or Sendai virus infection induced the two genes with similar kinetics, their induction kinetics in response to interferon-beta were quite different.
16385451 Observational study of gene-disease association. (HuGE Navigator)
12708317 The expression of interferon-induced genes IFI-54K and IFI-56K in the infected cells was found to increase 50-100-fold

AA Sequence

MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYLKHLKGQNEAA      1 - 70
LECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIESPELDC     71 - 140
EEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQY    141 - 210
LKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNN    211 - 280
AYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQY    281 - 350
EDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAK    351 - 420
MRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE                      421 - 472
//

Text Mined References (31)

PMID Year Title
25174799 2014 MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.
23867918 2014 Interferon-induced proteins with tetratricopeptide repeats 1 and 2 are cellular factors that limit hepatitis B virus replication.
23237964 2013 The broad-spectrum antiviral functions of IFIT and IFITM proteins.
22986528 2013 Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells.
22825553 2012 Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
22065572 2011 Inhibitor of ?B kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
21642987 2011 IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.
21190939 2011 The interferon stimulated gene 54 promotes apoptosis.
20950130 2011 The ISG56/IFIT1 gene family.
20506645 2010 [Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus].
19416887 2009 ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
18819931 2008 IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17030862 2006 Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein.
16973618 2006 Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.
16385451 2006 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
12708317 [Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus].
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9391139 1997 Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs.
8889549 1996 Generation and analysis of 280,000 human expressed sequence tags.
3466167 1986 Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.
3360121 1988 The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family.
3175763 1988 Cloning and chromosomal location of human genes inducible by type I interferon.
3119591 1987 Mechanism of interferon action. I. Characterization of a 54-kDa protein induced by gamma interferon with properties similar to a cytoskeletal component.
2454816 1988 Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses.
1377167 1992 The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24.