| Tbio | Little elongation complex subunit 2 |
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
Comments
| Disease | Target Count |
|---|---|
| Cocaine-Related Disorders | 88 |
| Paranoia | 8 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 4369 | 7.3e-09 |
| primitive neuroectodermal tumor | 3031 | 4.6e-07 |
| medulloblastoma, large-cell | 6234 | 1.4e-06 |
| sonic hedgehog group medulloblastoma | 1482 | 1.7e-06 |
| ovarian cancer | 8491 | 5.4e-06 |
| osteosarcoma | 7933 | 1.4e-05 |
| pilocytic astrocytoma | 3086 | 4.4e-05 |
| glioblastoma | 5572 | 7.6e-05 |
| pediatric high grade glioma | 2712 | 2.8e-04 |
| astrocytic glioma | 2241 | 1.4e-02 |
| non primary Sjogren syndrome sicca | 840 | 1.8e-02 |
| ependymoma | 2514 | 3.0e-02 |
| oligodendroglioma | 2849 | 3.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.300 | 1.4e-02 |
| ependymoma | 1.400 | 3.0e-02 |
| oligodendroglioma | 1.300 | 3.9e-02 |
| osteosarcoma | 2.180 | 1.4e-05 |
| glioblastoma | 1.800 | 7.6e-05 |
| sonic hedgehog group medulloblastoma | 2.100 | 1.7e-06 |
| atypical teratoid / rhabdoid tumor | 2.200 | 7.3e-09 |
| medulloblastoma, large-cell | 2.700 | 1.4e-06 |
| primitive neuroectodermal tumor | 1.700 | 4.6e-07 |
| pediatric high grade glioma | 1.300 | 2.8e-04 |
| pilocytic astrocytoma | 1.100 | 4.4e-05 |
| non primary Sjogren syndrome sicca | -1.600 | 1.8e-02 |
| ovarian cancer | -1.600 | 5.4e-06 |
MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELRVLSNRRIGENLNASASSVENEPAVSS 1 - 70 ATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQREQRSYVDLLVKYAKIPANSKAVGINKNDYLQYLDMKK 71 - 140 HVNEEVTEFLKFLQNSAKKCAQDYNMLSDDARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRVE 141 - 210 MGLKLEKTLLALGSVKYVKTVFPSMPIKLQLSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRYHPQI 211 - 280 ALTSQSLFTLLNNHGPTYKEQWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMTMRERNQIFHEVPLKFM 281 - 350 MSKNTSVPVSAVFMDKPEEFISEMDMSCEVNECRKIESLENLYLDFDDDVTELETFGVTTTKVSKSPSPA 351 - 420 STSTVPNMTDAPTAPKAGTTTVAPSAPDISANSRSLSQILMEQLQKEKQLVTGMDGGPEECKNKDDQGFE 421 - 490 SCEKVSNSDKPLIQDSDLKTSDALQLENSQEIETSNKNDMTIDILHADGERPNVLENLDNSKEKTVGSEA 491 - 560 AKTEDTVLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLSSRPASPNSSSGQASVGNQTNTACSPEESCV 561 - 630 LKKPIKRVYKKFDPVGEILKMQDELLKPISRKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSA 631 - 700 FQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVY 701 - 770 VLPKVEYQACYGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISN 771 - 840 LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLD 841 - 910 PSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKRK 911 - 980 IT 981 - 982 //
| PMID | Year | Title | |
|---|---|---|---|
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. | |
| 23932780 | 2013 | The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 22195968 | 2011 | The little elongation complex regulates small nuclear RNA transcription. | |
| 21269460 | 2011 | Initial characterization of the human central proteome. | |
| 19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. | |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 15606750 | 2004 | NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15146197 | 2004 | Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11297529 | 2001 | N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. | |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. |
