| Tbio | Little elongation complex subunit 2 |
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]
This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cocaine-Related Disorders | 92 | 0.0 | 0.0 |
| Paranoid Disorders | 8 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 4.9e-05 |
| glioblastoma | 5792 | 9.6e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.3e-04 |
| group 3 medulloblastoma | 4104 | 1.6e-04 |
| ovarian cancer | 8520 | 2.1e-04 |
| pediatric high grade glioma | 1064 | 2.8e-04 |
| primitive neuroectodermal tumor | 3035 | 1.2e-03 |
| osteosarcoma | 7950 | 2.1e-03 |
| astrocytic glioma | 2597 | 1.4e-02 |
| non primary Sjogren syndrome sicca | 891 | 1.8e-02 |
| medulloblastoma, large-cell | 6241 | 2.0e-02 |
| ependymoma | 4679 | 3.0e-02 |
| oligodendroglioma | 2850 | 3.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.300 | 1.4e-02 |
| Astrocytoma, Pilocytic | 1.100 | 4.9e-05 |
| atypical teratoid / rhabdoid tumor | 1.300 | 1.3e-04 |
| ependymoma | 1.400 | 3.0e-02 |
| glioblastoma | 1.100 | 9.6e-05 |
| group 3 medulloblastoma | 1.700 | 1.6e-04 |
| medulloblastoma, large-cell | 1.100 | 2.0e-02 |
| non primary Sjogren syndrome sicca | -1.600 | 1.8e-02 |
| oligodendroglioma | 1.300 | 3.9e-02 |
| osteosarcoma | -1.130 | 2.1e-03 |
| ovarian cancer | -1.200 | 2.1e-04 |
| pediatric high grade glioma | 1.300 | 2.8e-04 |
| primitive neuroectodermal tumor | 1.400 | 1.2e-03 |
MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELRVLSNRRIGENLNASASSVENEPAVSS 1 - 70 ATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQREQRSYVDLLVKYAKIPANSKAVGINKNDYLQYLDMKK 71 - 140 HVNEEVTEFLKFLQNSAKKCAQDYNMLSDDARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRVE 141 - 210 MGLKLEKTLLALGSVKYVKTVFPSMPIKLQLSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRYHPQI 211 - 280 ALTSQSLFTLLNNHGPTYKEQWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMTMRERNQIFHEVPLKFM 281 - 350 MSKNTSVPVSAVFMDKPEEFISEMDMSCEVNECRKIESLENLYLDFDDDVTELETFGVTTTKVSKSPSPA 351 - 420 STSTVPNMTDAPTAPKAGTTTVAPSAPDISANSRSLSQILMEQLQKEKQLVTGMDGGPEECKNKDDQGFE 421 - 490 SCEKVSNSDKPLIQDSDLKTSDALQLENSQEIETSNKNDMTIDILHADGERPNVLENLDNSKEKTVGSEA 491 - 560 AKTEDTVLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLSSRPASPNSSSGQASVGNQTNTACSPEESCV 561 - 630 LKKPIKRVYKKFDPVGEILKMQDELLKPISRKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSA 631 - 700 FQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVY 701 - 770 VLPKVEYQACYGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISN 771 - 840 LFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLD 841 - 910 PSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKRK 911 - 980 IT 981 - 982 //
