Tbio ICE1 Little elongation complex subunit 1

Protein Summary

Description

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).

Uniprot Accession IDs

• Q9Y2F5
• Q68DE1
• Q6ZT40
• Q7L587
• Q7Z3A9
• Q9NTH9

Gene Name

• ICE1

Ensembl ID

• ENST00000296564
• ENSP00000296564
• ENSG00000164151

Symbol

• KIAA0947
• KIAA0947

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
co-expressed gene	0.72
cellular component	0.71
tissue sample	0.7
biological process	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.17   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.17   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0