Tclin | 5-hydroxytryptamine receptor 2B |
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Comments
Property Summary
Ligand Count | 554 |
NCBI Gene PubMed Count | 69 |
PubMed Score | 486.27 |
PubTator Score | 175.63 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hypertension | 396 | 3.601 | 1.8 |
Cardiomegaly | 116 | 0.0 | 0.0 |
Drug-Related Side Effects and Adverse Reactions | 62 | 0.0 | 0.0 |
Heart Valve Diseases | 25 | 0.0 | 0.0 |
Heart failure | 162 | 0.0 | 0.0 |
Hypertension, Pulmonary | 37 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Adverse reaction to drug | 61 |
Heart valve disease | 39 |
Hypertensive disease | 292 |
Pulmonary hypertension | 85 |
Disease | Target Count | P-value |
---|---|---|
malignant mesothelioma | 3232 | 1.1e-05 |
psoriasis | 6694 | 1.1e-05 |
adrenocortical carcinoma | 1428 | 1.3e-05 |
osteosarcoma | 7950 | 1.1e-04 |
invasive ductal carcinoma | 2951 | 1.3e-02 |
non diabetic and post-ischemic heart failure | 200 | 4.4e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Heart disease | 306 | 3.935 | 2.0 |
Irritable bowel syndrome | 60 | 3.787 | 1.9 |
Schizophrenia | 1160 | 3.432 | 1.7 |
Hypoactive sexual desire disorder | 8 | 3.307 | 1.7 |
Obesity | 678 | 3.015 | 1.5 |
Disease | log2 FC | p |
---|---|---|
adrenocortical carcinoma | -3.234 | 1.3e-05 |
invasive ductal carcinoma | -1.300 | 1.3e-02 |
malignant mesothelioma | 1.600 | 1.1e-05 |
non diabetic and post-ischemic heart fai... | 1.200 | 4.4e-02 |
osteosarcoma | -3.617 | 1.1e-04 |
psoriasis | -4.000 | 1.1e-05 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA |
terguride
pKi 8.20
lisuride
pKi 8.49
mianserin
pKi 8.12
alosetron
pIC50 7.00
guanabenz
pIC50 7.01
doxepin
pIC50 7.05
thioridazine
pKi 7.09
chlorpromazine
pKi 7.10
cisapride
pKi 7.16
raloxifene
pKi 7.16
promethazine
pIC50 7.17
prochlorperazine
pKi 7.19
sorafenib
pKi 7.25
ketotifen
pIC50 7.34
desloratadine
pIC50 7.37
fluphenazine
pIC50 7.41
clemastine
pIC50 7.44
methysergide
pKi 8.12
methysergide
pKi 9.34
CHEMBL55472
pKi 7.00
CHEMBL12420
pKi 7.00
CHEMBL432217
pKi 7.00
CHEMBL278685
pKi 7.00
CHEMBL3813796
pIC50 7.00
CHEMBL234738
pKi 7.00
CHEMBL234533
pKi 7.00
CHEMBL1910139
pKi 7.00
CHEMBL2058415
pKi 7.00
CHEMBL293937
pKi 7.00
CHEMBL301409
pKi 7.00
CHEMBL14460
pKi 7.00
CHEMBL14563
pKi 7.00
CHEMBL53152
pKi 7.00
CHEMBL2337106
pEC50 7.00
CHEMBL3770225
pEC50 7.00
CHEMBL3764335
pKi 7.00
CHEMBL262862
pKi 7.00
CHEMBL597002
pKi 7.00
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIG 1 - 70 GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFST 71 - 140 ASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLT 141 - 210 KERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEK 211 - 280 VAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC 281 - 350 DSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP 351 - 420 MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV 421 - 481 //