Tbio HSD17B4 Peroxisomal multifunctional enzyme type 2

Protein Summary

Description

Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• P51659
• B4DNV1
• B4DVS5
• E9PB82
• F5HE57
• MFE-2

Gene Name

• HSD17B4

Ensembl ID

• ENST00000256216
• ENSP00000256216
• ENSG00000133835
• ENST00000414835
• ENSP00000411960
• ENST00000504811
• ENSP00000420914
• ENST00000510025
• ENSP00000424940
• ENST00000515320
• ENSP00000424613

Symbol

• EDH17B4
• SDR8C1
• DBP
• MFE-2
• MPF-2
• PRLTS1
• SDR8C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
disease perturbation	0.99
protein domain	0.92
kinase perturbation	0.91
protein complex	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.56   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 366   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.56   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 366   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0