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Tchem
HSD17B10
3-hydroxyacyl-CoA dehydrogenase type-2

Protein Summary
Description
Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the third step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecule ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000168216
  • ENSP00000168216
  • ENSG00000072506
  • ENST00000375304
  • ENSP00000364453

Symbol
  • ERAB
  • HADH2
  • MRPP2
  • SCHAD
  • SDR5C1
  • XH98G2
  • ABAD
  • CAMR
  • ERAB
  • HCD2
  • MHBD
  • HADH2
  • MRPP2
  • MRX17
  • MRX31
  • SCHAD
  • MRXS10
  • SDR5C1
  • HSD10MD
  • 17b-HSD10
  • DUPXp11.22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.96
kinase perturbation
0.96
virus perturbation
0.92
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.9   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 499   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.9   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 499   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0