Property Summary

NCBI Gene PubMed Count 4
PubMed Score 3.71
PubTator Score 17.23

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
ependymoma 2514 8.7e-13
medulloblastoma 1524 3.1e-05
glioblastoma 5572 4.8e-05
pediatric high grade glioma 2712 4.8e-05
medulloblastoma, large-cell 6234 1.1e-03
Disease Target Count Z-score Confidence
Choriocarcinoma 10 3.095 1.5

Expression

  Differential Expression (5)

Disease log2 FC p
ependymoma -1.200 8.7e-13
medulloblastoma -1.300 3.1e-05
glioblastoma -1.200 4.8e-05
medulloblastoma, large-cell -1.200 1.1e-03
pediatric high grade glioma -1.100 4.8e-05

Synonym

Accession Q7Z5J1 Q05D45 Q52LF4 Q7Z5I9 Q7Z5J0 Q7Z5P5 Q7Z5P6 Q7Z5P7 Q7Z5P8
Symbols HSD3
11-DH3
SCDR10
SCDR10B
SDR26C2
11-beta-HSD3

Gene

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG

Gene RIF (1)

PMID Text
19436836 cloning, purification, and characterization of SCDR10B; highly expressed in brain (especially in hippocampal neurons); up-regulated in lung cancer cell lines and lung cancer tissue

AA Sequence

MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVV      1 - 70
GNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFV     71 - 140
SYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVL    141 - 210
GLRDRASAAEAVRSSTSRPRQPEHRGVPLQSQTAMFLPPTVPGARTLTETPLRGWPQPKMKSSRQKSKTE    211 - 280
KNDGHLEPVTAWEVQVPRVRRLCRGLARPHLFGHD                                       281 - 315
//

Text Mined References (6)

PMID Year Title
20350543 2010 Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3.
19436836 2009 Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15057824 2004 The DNA sequence and biology of human chromosome 19.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.