Property Summary

NCBI Gene PubMed Count 11
PubMed Score 57.47
PubTator Score 29.26

Knowledge Summary


No data available


  Differential Expression (7)

Disease log2 FC p
cystic fibrosis -1.717 1.4e-06
medulloblastoma, large-cell -1.400 5.0e-05
intraductal papillary-mucinous adenoma (... -1.400 1.3e-05
intraductal papillary-mucinous carcinoma... -1.100 4.2e-02
breast carcinoma 1.200 6.8e-03
group 3 medulloblastoma -1.200 1.7e-03
ovarian cancer 1.300 9.6e-05

Protein-protein Interaction (2)

Gene RIF (5)

24563483 HS6ST-1 and HS6ST-2 have roles in regulating the angiogenic program in ovarian cancer cells affecting HB-EGF signaling and subsequent expression of angiogenic cytokines by cancer cells
24501377 Hs6st1 and Hs2st generate conditions conducive to corpus callosum development.
21700882 idiopathic hypogonadotrophic hypogonadism--associated HS6ST1 mutations display reduced activity in vitro and in vivo, suggesting that HS6ST1 and the complex modifications of extracellular sugars are critical for normal development
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
12492399 we have characterized HS6ST-2 and HS6ST-1 human isologues, including their chromosomal localizations,HS6STs could also transfer sulphate to N -sulphoglucosamine residues located at the non-reducing terminal of HS with high affinity.

AA Sequence


Text Mined References (13)

PMID Year Title
25077900 2014 The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients.
24563483 2014 Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.
24501377 2014 Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development.
23362303 2013 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
21700882 2011 Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12492399 2003 Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9535912 1998 Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells.