| Tbio | Inactive heparanase-2 |
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Urofacial syndrome | 7 | 6.799 | 3.4 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.4e-29 |
| inflammatory breast cancer | 286 | 1.0e-06 |
| invasive ductal carcinoma | 2951 | 3.3e-05 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Paget's disease of bone | 36 | 0.0 | 0.7 |
| Type 1 diabetes mellitus | 109 | 0.0 | 1.8 |
| Disease | Target Count |
|---|---|
| Ochoa syndrome | 2 |
| Disease | log2 FC | p |
|---|---|---|
| inflammatory breast cancer | -1.300 | 1.0e-06 |
| invasive ductal carcinoma | -1.810 | 3.3e-05 |
| psoriasis | -1.100 | 3.4e-29 |
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTLILLDVSTKNP 1 - 70 VRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRTDFLQFQNLRNPAKSRGGPGP 71 - 140 DYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLILTARSLDKL 141 - 210 YNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLG 211 - 280 KDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLK 281 - 350 TRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR 351 - 420 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNH 421 - 490 NYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKP 491 - 560 RPLRAGRTLVIPPVTMGFYVVKNVNALACRYR 561 - 592 //
