| Tdark | Hippocalcin-like protein 4 |
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3081 | 2.0e-11 |
| glioblastoma | 5792 | 2.8e-10 |
| medulloblastoma, large-cell | 6241 | 6.7e-09 |
| adult high grade glioma | 3801 | 3.8e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.5e-07 |
| group 3 medulloblastoma | 4104 | 1.2e-05 |
| primitive neuroectodermal tumor | 3035 | 1.2e-03 |
| pituitary cancer | 1972 | 3.9e-03 |
| ependymoma | 4679 | 3.9e-03 |
| astrocytic glioma | 2597 | 4.4e-03 |
| subependymal giant cell astrocytoma | 2287 | 4.6e-03 |
| Pick disease | 1894 | 1.4e-02 |
| oligodendroglioma | 2850 | 2.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Holoprosencephaly | 56 | 3.259 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -4.400 | 3.8e-08 |
| astrocytic glioma | -2.900 | 4.4e-03 |
| Astrocytoma, Pilocytic | -4.000 | 2.0e-11 |
| atypical teratoid / rhabdoid tumor | -4.400 | 1.5e-07 |
| ependymoma | -3.400 | 3.9e-03 |
| glioblastoma | -3.800 | 2.8e-10 |
| group 3 medulloblastoma | -4.500 | 1.2e-05 |
| medulloblastoma, large-cell | -5.300 | 6.7e-09 |
| oligodendroglioma | -1.700 | 2.2e-02 |
| Pick disease | -1.400 | 1.4e-02 |
| pituitary cancer | 1.700 | 3.9e-03 |
| primitive neuroectodermal tumor | -3.700 | 1.2e-03 |
| subependymal giant cell astrocytoma | -4.799 | 4.6e-03 |
