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Tbio
HP1BP3
Heterochromatin protein 1-binding protein 3

Protein Summary
Description
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312239
  • ENSP00000312625
  • ENSG00000127483
  • ENST00000375000
  • ENSP00000364139
  • ENST00000375003
  • ENSP00000364142

Symbol
  • HP1BP74
  • HP1-BP74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.99
drug perturbation
0.96
virus perturbation
0.95
small molecule perturbation
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.43   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.43   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0