Property Summary

NCBI Gene PubMed Count 21
PubMed Score 45.65
PubTator Score 24.30

Knowledge Summary


No data available


  Disease (2)

Gene RIF (7)

26545093 identified heterozygous HOXD4 loss-of-function mutations in three subjects with spinal extradural arachnoid cyst (SEDAC)
20686522 The results suggest that genetic polymorphisms in HOXD4 may not be a major contributor to the observed variability in peak BMD in the lumbar spine and the hip in Chinese men and women
20686522 Observational study of gene-disease association. (HuGE Navigator)
19938081 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19453261 Observational study of gene-disease association. (HuGE Navigator)
19232136 microRNA-10a (miR-10a) targets a homologous DNA region in the promoter region of the hoxd4 gene and represses its expression at the transcriptional level
15776434 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence


Text Mined References (22)

PMID Year Title
26545093 2015 Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.
20686522 2010 Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.
19938081 2009 Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
19453261 2009 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
19232136 2009 Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells.
15776434 2005 Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11857506 2002 Complete mutation analysis panel of the 39 human HOX genes.
11778160 2002 A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly.
11585930 2001 The HOX homeodomain proteins block CBP histone acetyltransferase activity.
11060466 2000 Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1.
10523646 1999 PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins.
10364522 1999 Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster.
9748262 1998 Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.
7913891 1994 The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.
2879245 1986 Differential and stage-related expression in embryonic tissues of a new human homoeobox gene.
2576652 1989 Organization of human class I homeobox genes.
1975093 1990 Molecular mechanisms underlying the expression of the human HOX-5.1 gene.
1973146 1990 Nomenclature for human homeobox genes.
1358459 1992 Vertebrate homeobox gene nomenclature.