| Tbio | Homeobox protein Hox-A3 |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count |
|---|---|
| Congenital Heart Defects | 37 |
| Craniofacial Abnormalities | 147 |
| Hypospadias | 65 |
| Lymphatic Abnormalities | 1 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1614 | 4.4e-38 |
| Breast cancer | 3098 | 6.8e-25 |
| posterior fossa group A ependymoma | 1511 | 2.1e-09 |
| ulcerative colitis | 2087 | 3.3e-04 |
| sonic hedgehog group medulloblastoma | 1482 | 4.5e-04 |
| pancreatic cancer | 2300 | 5.3e-04 |
| primary pancreatic ductal adenocarcinoma | 1271 | 5.4e-04 |
| interstitial cystitis | 2299 | 1.2e-03 |
| ovarian cancer | 8491 | 1.3e-03 |
| nasopharyngeal carcinoma | 1056 | 5.9e-03 |
| adult high grade glioma | 2148 | 8.4e-03 |
| head and neck cancer | 270 | 1.4e-02 |
| glioblastoma | 5572 | 1.6e-02 |
| non primary Sjogren syndrome sicca | 840 | 2.1e-02 |
| gastric carcinoma | 832 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| VACTERL association | 23 | 4.136 | 2.1 |
| Cervical incompetence | 7 | 3.603 | 1.8 |
| Esophageal atresia | 25 | 3.248 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.800 | 1.6e-02 |
| posterior fossa group A ependymoma | 4.400 | 2.1e-09 |
| sonic hedgehog group medulloblastoma | 4.000 | 4.5e-04 |
| primary pancreatic ductal adenocarcinoma | 1.530 | 5.4e-04 |
| pancreatic cancer | 1.500 | 5.3e-04 |
| interstitial cystitis | -1.500 | 1.2e-03 |
| adult high grade glioma | 2.400 | 8.4e-03 |
| non primary Sjogren syndrome sicca | -1.100 | 2.1e-02 |
| nasopharyngeal carcinoma | 1.800 | 5.9e-03 |
| Breast cancer | -4.200 | 6.8e-25 |
| breast carcinoma | -1.800 | 4.4e-38 |
| gastric carcinoma | 1.800 | 2.5e-02 |
| ulcerative colitis | -1.300 | 3.3e-04 |
| ovarian cancer | -2.500 | 1.3e-03 |
| head and neck cancer | -1.800 | 1.4e-02 |
| PMID | Text | |
|---|---|---|
| 24127533 | aim of this work was to search for mutations in thyroid developmental candidate genes HOXA3, HOXB3, HOXD3 and PITX2 | |
| 19453261 | Observational study of gene-disease association. (HuGE Navigator) | |
| 17972163 | HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed during angiogenesis, sugessting these proteins might be involved in the angiogenesis of hMSCs. |
MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEA 1 - 70 CLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANA 71 - 140 AKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEF 141 - 210 HFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSM 211 - 280 HSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQ 281 - 350 GNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPT 351 - 420 YTDLTGHHPSQGRIQEAPKLTHL 421 - 443 //
| PMID | Year | Title | |
|---|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 25108383 | 2014 | Genome-wide association analyses identify variants in developmental genes associated with hypospadias. | |
| 24127533 | 2014 | The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis. | |
| 21516116 | 2011 | Next-generation sequencing to generate interactome datasets. | |
| 19453261 | 2009 | High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. | |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 17972163 | 2009 | HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. | |
| 17567994 | 2007 | Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. | |
| 16959974 | 2006 | The consensus coding sequences of human breast and colorectal cancers. | |
| 16582099 | 2006 | The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12853948 | 2003 | The DNA sequence of human chromosome 7. | |
| 12690205 | 2003 | Human chromosome 7: DNA sequence and biology. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11857506 | 2002 | Complete mutation analysis panel of the 39 human HOX genes. | |
| 11823429 | 2002 | Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. | |
| 9894676 | 1998 | Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. | |
| 9847074 | 1998 | Toward a complete human genome sequence. | |
| 9520319 | 1998 | Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. | |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. | |
| 8646877 | 1996 | Fine mapping of human HOX gene clusters. | |
| 1973146 | 1990 | Nomenclature for human homeobox genes. | |
| 1358459 | 1992 | Vertebrate homeobox gene nomenclature. |
