| Tbio | Homeobox protein Hox-A3 |
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Craniofacial Abnormalities | 151 | 0.0 | 0.0 |
| Heart Defects, Congenital | 37 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Lymphatic Abnormalities | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Congenital Heart Defects | 58 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 4.4e-38 |
| Breast cancer | 3578 | 6.8e-25 |
| ulcerative colitis | 1819 | 3.3e-04 |
| pancreatic cancer | 2398 | 5.3e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 5.4e-04 |
| interstitial cystitis | 2312 | 1.2e-03 |
| ovarian cancer | 8520 | 1.3e-03 |
| nasopharyngeal carcinoma | 1058 | 5.9e-03 |
| adult high grade glioma | 3801 | 8.4e-03 |
| ependymoma | 4679 | 1.3e-02 |
| head and neck cancer | 271 | 1.4e-02 |
| glioblastoma | 5792 | 1.6e-02 |
| group 3 medulloblastoma | 4104 | 1.8e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.1e-02 |
| gastric carcinoma | 807 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| hand-foot-genital syndrome | 9 | 4.622 | 2.3 |
| VACTERL association | 26 | 4.085 | 2.0 |
| Cervical incompetence | 6 | 3.596 | 1.8 |
| Esophageal atresia | 43 | 3.207 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 2.400 | 8.4e-03 |
| Breast cancer | -4.200 | 6.8e-25 |
| breast carcinoma | -1.800 | 4.4e-38 |
| ependymoma | 2.200 | 1.3e-02 |
| gastric carcinoma | 1.800 | 2.5e-02 |
| glioblastoma | 1.800 | 1.6e-02 |
| group 3 medulloblastoma | 2.500 | 1.8e-02 |
| head and neck cancer | -1.800 | 1.4e-02 |
| interstitial cystitis | -1.500 | 1.2e-03 |
| nasopharyngeal carcinoma | 1.800 | 5.9e-03 |
| non primary Sjogren syndrome sicca | -1.100 | 2.1e-02 |
| ovarian cancer | -2.500 | 1.3e-03 |
| pancreatic cancer | 1.500 | 5.3e-04 |
| primary pancreatic ductal adenocarcinoma | 1.530 | 5.4e-04 |
| ulcerative colitis | -1.300 | 3.3e-04 |
MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEA 1 - 70 CLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANA 71 - 140 AKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEF 141 - 210 HFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSM 211 - 280 HSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQ 281 - 350 GNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPT 351 - 420 YTDLTGHHPSQGRIQEAPKLTHL 421 - 443 //
