Tbio HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like

Protein Summary

Description

Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• O14979
• Q6SPF2
• Q7KZ74
• Q7KZ75
• Q96IM0
• Q96S43
• hnRNP D-like

Gene Name

• HNRNPDL

Ensembl ID

• ENST00000295470
• ENSP00000295470
• ENSG00000152795
• ENST00000349655
• ENSP00000338552
• ENST00000502762
• ENSP00000422040
• ENST00000507721
• ENSP00000480156
• ENST00000602300
• ENSP00000473677
• ENST00000621267
• ENSP00000483254
• ENST00000630114
• ENSP00000486452
• ENST00000630827
• ENSP00000485954

Symbol

• HNRPDL
• JKTBP
• HNRNP
• JKTBP
• HNRPDL
• JKTBP2
• LGMD1G
• LGMDD3
• laAUF1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	1
ligand (protein) perturbation	0.99
transcription factor binding site profile	0.92
kinase perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.52   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.52   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0