Tbio HMGN2 Non-histone chromosomal protein HMG-17

Protein Summary

Description

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P05204
• Q0VGD5
• Q6FGI5
• Q96C64

Gene Name

• HMGN2

Ensembl ID

• ENST00000361427
• ENSP00000355228
• ENSG00000198830
• ENST00000619352
• ENSP00000481160

Symbol

• HMG17
• HMG17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
histone modification site profile	0.88
transcription factor binding site profile	0.85
virus perturbation	0.83
transcription factor	0.81

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Non-histone Chromosomal Protein Hmg-17

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Non-histone Chromosomal Protein Hmg-17

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.48   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.48   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0