| Tbio | High mobility group protein HMG-I/HMG-Y |
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Diabetes Mellitus, Type 2 | 142 | 0.0 | 0.0 |
| Hyperglycemia | 137 | 0.0 | 0.0 |
| Insulin Resistance | 72 | 0.0 | 0.0 |
| Leiomyosarcoma | 24 | 0.0 | 0.0 |
| Metabolic Syndrome | 20 | 0.0 | 0.0 |
| Uterine Neoplasms | 9 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Diabetes Mellitus, Non-Insulin-Dependent | 145 |
| Metabolic syndrome X | 52 |
| Schizophrenia | 1160 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.0e-21 |
| posterior fossa group B ependymoma | 416 | 5.6e-08 |
| ovarian cancer | 8520 | 4.6e-07 |
| glioblastoma | 5792 | 5.8e-05 |
| osteosarcoma | 7950 | 7.6e-05 |
| pediatric high grade glioma | 1064 | 9.2e-05 |
| pancreatic cancer | 2398 | 1.1e-04 |
| lung cancer | 4740 | 2.9e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.6e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.3e-03 |
| ductal carcinoma in situ | 1745 | 1.7e-03 |
| medulloblastoma, large-cell | 6241 | 1.8e-03 |
| invasive ductal carcinoma | 2951 | 2.8e-03 |
| colon cancer | 1478 | 3.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 3.0 |
| Disease | Target Count |
|---|---|
| AOMS1 | 4 |
| Diabetes Mellitus, Noninsulin-Dependent | 31 |
| Type 2 diabetes mellitus | 272 |
| Disease | log2 FC | p |
|---|---|---|
| colon cancer | 1.400 | 3.0e-02 |
| ductal carcinoma in situ | 1.300 | 1.7e-03 |
| glioblastoma | 1.700 | 5.8e-05 |
| intraductal papillary-mucinous carcinoma... | 1.200 | 4.6e-04 |
| invasive ductal carcinoma | 1.800 | 2.8e-03 |
| lung cancer | 2.100 | 2.9e-04 |
| medulloblastoma, large-cell | 2.100 | 1.8e-03 |
| non-small cell lung cancer | 1.950 | 3.0e-21 |
| osteosarcoma | -2.615 | 7.6e-05 |
| ovarian cancer | 1.900 | 4.6e-07 |
| pancreatic cancer | 1.200 | 1.1e-04 |
| pancreatic ductal adenocarcinoma liver m... | 2.284 | 1.3e-03 |
| pediatric high grade glioma | 1.300 | 9.2e-05 |
| posterior fossa group B ependymoma | -1.300 | 5.6e-08 |
