Property Summary

NCBI Gene PubMed Count 68
PubMed Score 2966.40
PubTator Score 385.55

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (19)

Disease log2 FC p
Multiple myeloma 2.111 3.0e-03
psoriasis -2.200 8.1e-04
osteosarcoma -1.867 6.3e-03
cystic fibrosis 1.290 1.0e-03
intraductal papillary-mucinous carcinoma... 2.300 6.3e-03
intraductal papillary-mucinous neoplasm ... 2.700 2.8e-03
colon cancer -2.200 2.2e-02
pancreatic cancer 1.600 1.3e-04
Breast cancer 3.700 4.5e-02
group 4 medulloblastoma -1.100 3.2e-03
pilocytic astrocytoma -1.300 2.1e-06
nasopharyngeal carcinoma -1.300 1.4e-05
lung carcinoma 1.800 5.3e-22
breast carcinoma 1.400 3.8e-21
spina bifida -2.011 4.3e-02
ductal carcinoma in situ 2.900 7.1e-04
invasive ductal carcinoma 3.600 9.2e-04
ovarian cancer 1.900 1.1e-05
pituitary cancer 2.000 5.1e-06

 GO Function (1)

Gene RIF (27)

PMID Text
27098497 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent DNA repair resection.
26974126 The 2.7-A-resolution crystal structure of the human YL1-H2A.Z-H2B complex shows that YL1 binding, similarly to ANP32E binding, triggers an extension of the H2A.Z alphaC helix.
26904685 All cases with ARID1A expression are overlapped with H2B high expression. Among 15 cases with ARID1A and H2B coexpression, 13 are invasive ductal carcinoma and 2 are mucinous carcinoma. Our results indicate that ARID1A gene may be involved in carcinogenesis of some subtypes of breast cancer.
26852132 Gene expression analysis identified deregulation of histone H2A and H2B genes in all four cell lines ;histone pathways are associated with epirubicin resistance
26424599 Study provides the first observation of the proteolytic processing of histones H2B and H3 in human hepatocytes where four different clipping sites were localized in H3 and one in H2B.
26240340 analysis of a functional hotspot on ubiquitin that is required for the stimulation of human Dot1
25049226 Results show that the cotranscriptional ubiquitylation of histone H2B suggests that it may be more intimately involved in ongoing nucleosome turnover in the wake of Pol II.
24837678 H2B K34 ubiquitylation by the MOF-MSL complex is part of the protein networks involved in early steps of transcription elongation.
24339737 Knockdown of EZH2 increased the ubiquitination level of H2BK120.
22967069 Autoimmunity to isoAsp histone H2B suggests that this form of the autoantigen may be critical in the induction of anti-histone autoantibodies in human SLE.
22615809 cancerous cells in the tumor specimens. Taken together, our data suggest that glucose deficiency and loss of uH2B are novel properties of cancer cells in vivo, which may represent important regulatory mechanisms of tumorigenesis
22421545 after H2B monoubiquitylation H2B is largely positioned at the exon-intron boundaries of highly expressed exons, and it demonstrates increased occupancy in skipped exons compared with flanking exons in the human genome
22174317 HIV-1 Rev interacting protein, histone cluster 2, H2be (HIST2H2BE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
21994445 H2B and H4 histones were mobilized during herpes simplex virus 1 infection and became available to bind to viral genomes.
21827756 Studies indicate that H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40.
21739721 these data point at acetylation of Lysine 120 of H2B as an early mark of poised or active state and establish a temporal sequence between acetylation and mono-ubiquitination of this H2B residue.
20599239 HIV-1 Rev interacting protein, histone cluster 2, H2be (HIST2H2BE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
19425504 NO-mediated H2B gene repression depends on modifications of endogenous PPAR ligands.
19410543 These studies establish the natural H2B ubiquitylation factors in human cells and also detail the mechanistic basis for H2B ubiquitylation and function during transcription
18682386 A redox-modulated direct p38/GAPDH-Oct-1 interaction nucleates the occupancy of the H2B promoter by the OCA-S complex, in which p36/LDH plays a critical role in the hierarchical organization of the complex.
18206972 The 2 MDa GCN5 HAT-containing metazoan TFTC/STAGA complexes contain a histone H2A and H2B deubiquitinase activity.
17074886 Protein phosphatase 2C gamma binds to/dephosporylates histone 2b to affect chromatin function.
14657027 HIV-1 Rev interacting protein, histone cluster 2, H2be (HIST2H2BE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
12860195 Histone H2B antimicrobial peptides participate in the colonic defense against bacteria and fungi.
11689053 HIV-1 Rev interacting protein, histone cluster 2, H2be (HIST2H2BE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
11080476 HIV-1 Rev interacting protein, histone cluster 2, H2be (HIST2H2BE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells
9566873 HIV-1 Rev interacting protein, histone cluster 2, H2be (HIST2H2BE), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells

AA Sequence

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDI      1 - 70
FERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK                   71 - 126
//

Text Mined References (71)

PMID Year Title
27098497 2016 CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection.
26974126 2016 Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
26904685 2016 Expressing Status and Correlation of ARID1A and Histone H2B on Breast Cancer.
26852132 2016 Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer.
26424599 2015 Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns.
26240340 2015 Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.
25049226 2014 Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.
24837678 2014 H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb.
24339737 2013 The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.
23824326 2013 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.
22967069 2013 Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.
22615809 2012 Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors.
22421545 2012 H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cells.
21994445 2011 Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1.
21925322 2011 Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.
21827756 2011 RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.
21739721 2011 An acetylation-mono-ubiquitination switch on lysine 120 of H2B.
21726816 2011 The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.
21630459 2011 Proteomic characterization of the human sperm nucleus.
19425504 [Role of transcription factors binding sites in no-mediated histone H2B promoter repression].
19410543 2009 RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.
19199708 2009 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
18682386 2008 Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status.
18206972 2008 A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
17074886 2006 A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
16916647 2006 Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
16713563 2006 Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16627869 2006 Quantitative proteomic analysis of post-translational modifications of human histones.
16457587 2006 Gene-specific characterization of human histone H2B by electron capture dissociation.
16319397 2006 Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry.
16307923 2005 Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.
16283522 2005 Inhibition of core histones acetylation by carcinogenic nickel(II).
15635413 2005 Nucleolar proteome dynamics.
15601853 2005 Reading and function of a histone code involved in targeting corepressor complexes for repression.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15019208 2003 Antimicrobial polypeptides of the human colonic epithelium.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14657027 2003 Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.
12888554 2003 HAMLET interacts with histones and chromatin in tumor cell nuclei.
12860195 2003 Antimicrobial peptides in the first line defence of human colon mucosa.
12786946 2003 Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.
12757711 2003 Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.
12628926 2003 Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.
12489984 2003 Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12408966 2002 The human and mouse replication-dependent histone genes.
11859126 2002 Endotoxin-neutralizing antimicrobial proteins of the human placenta.
11824786 2001 Core histones and linker histones are imported into the nucleus by different pathways.
11689053 2001 Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.
11375490 2001 Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B.
11310559 2001 Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha.
11266453 2001 A novel chromatin protein, distantly related to histone H2A, is largely excluded from the inactive X chromosome.
11241673 2001 Characterisation of nuclear localisation signals of the four human core histones.
11080476 2000 Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.
10821277 2000 ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.
10022855 1999 Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.
9973324 1999 Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis.
9973250 1999 Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
9748265 1998 Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.
9724719 1998 Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane.
9710638 1998 Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA.
9651585 1998 SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
9566873 1998 Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.
9325046 1997 Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.
8620898 1996 Biochemical and antibacterial analysis of human wound and blister fluid.
8180162 1994 Dynamics of the interactions of histones H2A,H2B and H3,H4 with torsionally stressed DNA.
1993178 1991 Isolation and characterization of a cDNA from a human histone H2B gene which is reciprocally expressed in relation to replication-dependent H2B histone genes during HL60 cell differentiation.
1469070 1992 A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing.