| Tdark | Histone H2A type 2-B |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung carcinoma | 317 | 1.4e-19 |
| Breast cancer | 3578 | 7.3e-08 |
| lung adenocarcinoma | 2716 | 1.9e-07 |
| breast carcinoma | 1638 | 1.5e-03 |
| diabetes mellitus | 1728 | 2.8e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Atypical teratoid rhabdoid tumor | 6 | 3.697 | 1.8 |
| Autoimmune thyroiditis | 27 | 3.296 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 1.900 | 7.3e-08 |
| breast carcinoma | 1.400 | 1.5e-03 |
| diabetes mellitus | -1.200 | 2.8e-03 |
| lung adenocarcinoma | 1.800 | 1.9e-07 |
| non-small cell lung carcinoma | 1.200 | 1.4e-19 |
