| Tbio | Histone H2B type 1-D |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 8.0e-26 |
| non-small cell lung cancer | 2890 | 6.2e-17 |
| lung carcinoma | 2843 | 2.2e-15 |
| lung adenocarcinoma | 2716 | 6.0e-11 |
| cystic fibrosis | 1696 | 1.1e-06 |
| ovarian cancer | 8520 | 6.1e-06 |
| pancreatic cancer | 2398 | 1.4e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.5e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 6.2e-04 |
| psoriasis | 6694 | 6.5e-04 |
| lung cancer | 4740 | 9.2e-04 |
| ductal carcinoma in situ | 1745 | 2.3e-03 |
| invasive ductal carcinoma | 2951 | 3.0e-03 |
| cutaneous lupus erythematosus | 1057 | 5.3e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.2e-03 |
| gastric cancer | 459 | 8.4e-03 |
| Multiple myeloma | 1332 | 1.3e-02 |
| Breast cancer | 3578 | 2.4e-02 |
| glioblastoma | 5792 | 3.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ankylosing spondylitis | 140 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 3.600 | 2.4e-02 |
| breast carcinoma | 1.700 | 8.0e-26 |
| cutaneous lupus erythematosus | 1.100 | 5.3e-03 |
| cystic fibrosis | 1.671 | 1.1e-06 |
| ductal carcinoma in situ | 2.700 | 2.3e-03 |
| gastric cancer | -1.100 | 8.4e-03 |
| glioblastoma | 1.600 | 3.1e-02 |
| intraductal papillary-mucinous adenoma (... | 1.900 | 4.5e-04 |
| intraductal papillary-mucinous carcinoma... | 1.900 | 8.2e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.800 | 6.2e-04 |
| invasive ductal carcinoma | 3.900 | 3.0e-03 |
| lung adenocarcinoma | 1.100 | 6.0e-11 |
| lung cancer | 2.300 | 9.2e-04 |
| lung carcinoma | 1.300 | 2.2e-15 |
| Multiple myeloma | 1.295 | 1.3e-02 |
| non-small cell lung cancer | 1.731 | 6.2e-17 |
| ovarian cancer | 1.500 | 6.1e-06 |
| pancreatic cancer | 1.700 | 1.4e-05 |
| psoriasis | -1.700 | 6.5e-04 |
