Tbio | Histone H2B type 1-A |
Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133).
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Papillary adenoma | 4 | 3.883 | 1.9 |
Male infertility | 206 | 3.829 | 1.9 |
Testicular cancer | 25 | 3.163 | 1.6 |
Primary ciliary dyskinesia | 76 | 3.018 | 1.5 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA |
NAP1L1
NAP1L4
RUVBL1
MIER1
HDAC1
HDAC2
EP400
GON4L
MEAF6
H2AFY2
H2AFY
SUPT16H
LIG3
ACTL6A
ACTL6B
EPC1
EPC2
PARP2
PHF14
PARP1
SRCAP
DMAP1
TCF20
ARID5B
TRRAP
C16orf87
HLTF
MCM7
MCM2
IPO9
BRD8
HIST1H1T
PPM1G
VPS72
EHMT2
HIST1H2BL
MMS22L
MCM6
SSRP1
ING3
H2AFZ
HIST1H2AG
HIST2H2AB
TEX10
BAHD1
MIER3
RUVBL2
CRAMP1
ANP32E
MCM4
ACTR6
XPC
CFDP1
KAT5
CETN2
UBE2O
MBTD1
MORF4L1
MRGBP
TONSL
CDYL
GINS3
YEATS4
XRCC1
APLF
JAZF1
ZNHIT1
HMG20A
TRIM41