| Tbio | Histone H2B type 1-A |
Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Papillary adenoma | 3 | 4.017 | 2.0 |
| Male infertility | 170 | 3.593 | 1.8 |
| Testicular cancer | 24 | 3.226 | 1.6 |
| Primary ciliary dyskinesia | 75 | 3.132 | 1.6 |
RNF40
UBB
UBC
RNF20
CDC73
CTR9
PAF1
LEO1
RTF1
WAC
WDR61
NAP1L1
NAP1L4
RUVBL1
MIER1
HDAC1
HDAC2
EP400
GON4L
MEAF6
H2AFY2
H2AFY
SUPT16H
LIG3
ACTL6A
ACTL6B
EPC1
EPC2
PARP2
PHF14
PARP1
SRCAP
DMAP1
TCF20
ARID5B
TRRAP
C16orf87
HLTF
MCM7
MCM2
IPO9
BRD8
HIST1H1T
PPM1G
VPS72
EHMT2
HIST1H2BL
MMS22L
MCM6
SSRP1
ING3
H2AFZ
HIST1H2AG
HIST2H2AB
TEX10
BAHD1
MIER3
RUVBL2
CRAMP1
ANP32E
MCM4
ACTR6
XPC
CFDP1
KAT5
CETN2
UBE2O
MBTD1
MORF4L1
MRGBP
TONSL
CDYL
GINS3
YEATS4
XRCC1
APLF
JAZF1
ZNHIT1
HMG20A
TRIM41
| PMID | Text | |
|---|---|---|
| 26759222 | Data show that histone H2B of prostate cancer cell line DU-145 have hypoacetylation, hypomethylation, and dephosphorylation, suggesting there was an excessive histone deacetylase activity in the cells. | |
| 15709765 | Reconstituted TSH2B containing octamers are able to form nucleosome core particles which are structurally and dynamically indistinguishable from those reconstituted with octamers consisting of only native histones. | |
| 14657027 | HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness | |
| 11689053 | HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness | |
| 11080476 | HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness | |
| 9566873 | HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness |
| PMID | Year | Title | |
|---|---|---|---|
| 26759222 | 2016 | Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells. | |
| 26649967 | 2016 | Two Histone Variants TH2A and TH2B Enhance Human Induced Pluripotent Stem Cell Generation. | |
| 24699735 | 2014 | Structure of human nucleosome containing the testis-specific histone variant TSH2B. | |
| 24614311 | 2014 | Every amino acid matters: essential contributions of histone variants to mammalian development and disease. | |
| 23884607 | 2013 | Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B. | |
| 21925322 | 2011 | Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. | |
| 21726816 | 2011 | The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. | |
| 21630459 | 2011 | Proteomic characterization of the human sperm nucleus. | |
| 21249133 | 2011 | Histone variants and their post-translational modifications in primary human fat cells. | |
| 19135898 | 2009 | Purification of proteins associated with specific genomic Loci. | |
| 16916647 | 2006 | Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. | |
| 16713563 | 2006 | Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. | |
| 16307923 | 2005 | Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. | |
| 16283522 | 2005 | Inhibition of core histones acetylation by carcinogenic nickel(II). | |
| 15709765 | 2005 | Characterization of nucleosomes consisting of the human testis/sperm-specific histone H2B variant (hTSH2B). | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 14657027 | 2003 | Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. | |
| 14574404 | 2003 | The DNA sequence and analysis of human chromosome 6. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12408966 | 2002 | The human and mouse replication-dependent histone genes. | |
| 12213818 | 2002 | Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. | |
| 11689053 | 2001 | Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA. | |
| 11080476 | 2000 | Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. | |
| 9566873 | 1998 | Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. |
