HIPK4
Homeodomain-interacting protein kinase 4
Protein Summary
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]
- ENST00000291823
- ENSP00000291823
- ENSG00000160396
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule | 1 | ||
molecular function | 0.91 | ||
protein domain | 0.73 | ||
cell line | 0.53 | ||
cell type or tissue | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.5 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 268 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.5 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 268 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 39
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1