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Tchem
HIPK3
Homeodomain-interacting protein kinase 3

Protein Summary
Description
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303296
  • ENSP00000304226
  • ENSG00000110422
  • ENST00000379016
  • ENSP00000368301
  • ENST00000456517
  • ENSP00000398241
  • ENST00000525975
  • ENSP00000431710

Symbol
  • DYRK6
  • FIST3
  • PKY
  • PKY
  • YAK1
  • DYRK6
  • FIST3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.93
molecular function
0.9
small molecule
0.89
biological process
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.95   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.95   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0