Tchem HIPK1 Homeodomain-interacting protein kinase 1

Protein Summary

Description

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86Z02
• A6NJ34
• O75125
• Q5SQL2
• Q5SQL4
• Q5SQL5
• Q8IYD7
• Q8NDN5
• Q8NEB6
• Q8TBZ1

Gene Name

• HIPK1

Ensembl ID

• ENST00000340480
• ENSP00000340956
• ENSG00000163349
• ENST00000369553
• ENSP00000358566
• ENST00000369558
• ENSP00000358571
• ENST00000369559
• ENSP00000358572
• ENST00000426820
• ENSP00000407442

Symbol

• KIAA0630
• MYAK
• NBAK2
• Myak
• Nbak2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
small molecule	0.96
transcription factor	0.94
molecular function	0.91
microRNA	0.9

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Homeodomain-interacting Protein Kinase 1

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Homeodomain-interacting Protein Kinase 1

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Dyrk Family / Hipk Subfamily / Homeodomain-interacting Protein Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.49   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.49   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0