Property Summary

NCBI Gene PubMed Count 66
PubMed Score 55.68
PubTator Score 101.21

Knowledge Summary


No data available


  Differential Expression (24)

Disease log2 FC p
Rheumatoid Arthritis 1.800 2.0e-03
malignant mesothelioma -2.400 2.1e-06
psoriasis -1.700 1.7e-04
astrocytoma 1.200 8.2e-11
glioblastoma 2.400 5.7e-06
oligodendroglioma 1.200 3.1e-09
osteosarcoma 1.428 2.5e-03
atypical teratoid / rhabdoid tumor 1.600 1.3e-05
medulloblastoma, large-cell 1.700 1.7e-04
primitive neuroectodermal tumor 1.800 4.5e-04
adrenocortical carcinoma 1.170 4.5e-03
primary pancreatic ductal adenocarcinoma 1.391 1.8e-03
diabetes mellitus 1.200 2.6e-03
pediatric high grade glioma 1.800 1.6e-06
group 3 medulloblastoma 1.500 2.6e-03
pilocytic astrocytoma 2.500 9.8e-12
aldosterone-producing adenoma -1.214 5.7e-03
lung carcinoma -1.500 4.2e-15
spina bifida 1.385 4.0e-02
gastric carcinoma 1.300 9.7e-03
ovarian cancer 1.500 6.4e-05
Down syndrome 1.100 6.9e-04
pancreatic cancer 1.200 6.7e-03
facioscapulohumeral dystrophy -1.300 4.0e-02

Gene RIF (28)

26595459 Huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis. metastasis. Read More:
26437767 HIP1 deletion is not involved in Williams-Beuren syndrome.
25496667 Genome-wide shRNA screening identifies HIP1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells
25082541 SHON plays an important role in EMT and contributes to breast cancer progression.
24518094 HIP1-ALK, a novel fusion protein is associated with lung adenocarcinoma.
24496003 HIP1-ALK-rearranged tumor is sensitive to treatment with crizotinib, implicating HIP1-ALKas an oncogenic driver of lung tumorigenesis
24296488 SHON is a novel human oncogene with predictive utility in ER(+) breast cancer, perhaps offering a simple biomarker to predict the therapeutic efficacy of antiestrogen therapy in patients with breast cancer.
23836884 Identified a four-tyrosine "HIP1 phosphorylation motif" in the N-terminal region of HIP1 that is required for phosphorylation mediated by both EGFR and PDGFbetaR but not by the oncoproteins HIP1/PDGFbetaR (H/P), and TEL/PDGFbetaR (T/P).
22913984 Three neuronal proteins (Huntingtin interacting protein 1, neurofascin, and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.
22835334 flexibility of the HIP1 coiled-coil domain is important for normal function and may lead to new insights into Huntington's disease
22360420 A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
21697888 Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit
21109226 data characterize a neurodevelopmental and epilepsy syndrome that is likely caused by recurrent and nonrecurrent deletions, including HIP1
20179344 hydrogen-bond network and changes in coiled-coil monomer interaction suggest that the HIP1 coiled-coil domain is uniquely suited to allow conformational flexibility.
19626275 Data demonstrate HIP1's role in pits maturation and formation of the coated vesicle, and its strong dependence on clathrin for membranal localization.
18790740 Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain
18155047 Crystal structure at 2.8 A of HIP1 coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).
17452370 Human HIP1 transgenic Hip1/Hip1r knockout mice are completely free from dwarfism and spinal defects.
16979168 neurotoxic signals of Hip1 transmit through the intrinsic mitochondrial apoptotic pathwaysand the formation of apoptosome complex
16847693 Observational study of gene-disease association. (HuGE Navigator)
16027218 HIP1 is a nucleocytoplasmic protein capable of associating with membranes and DNA response elements and regulating transcription.
15581353 The F-actin binding capacity of Hip1 is regulated by intrasteric occlusion of primary actin-binding determinants within the Hip1 I/LWEQ module.
15533940 roles of Hip1 and Hip1R in affecting clathrin assembly and actin distribution are mediated by their interaction with the conserved sequence of clathrin light chain
15059611 HIP1 has roles in endocytosis and receptor trafficking and in tumorigenesis
14732715 both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains.
12163454 huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival
11889126 HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
11788820 Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway.

AA Sequence


Text Mined References (71)

PMID Year Title
26595459 2016 Huntingtin-Interacting Protein-1 Is an Early-Stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated Epithelial-Mesenchymal Transition.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26437767 2016 Epilepsy is a possible feature in Williams-Beuren syndrome patients harboring typical deletions of the 7q11.23 critical region.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
25241761 2014 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
25082541 2015 SHON, a novel secreted protein, regulates epithelial-mesenchymal transition through transforming growth factor-? signaling in human breast cancer cells.
24951543 2014 Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
24518094 2014 HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.
24496003 2014 HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.
24296488 2013 SHON is a novel estrogen-regulated oncogene in mammary carcinoma that predicts patient response to endocrine therapy.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23836884 2013 Huntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.
22913984 2013 Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.
22835334 2012 Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death.
22360420 2012 Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
21697888 2011 Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.
21529783 2011 A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
21269460 2011 Initial characterization of the human central proteome.
21109226 2010 Recurrent distal 7q11.23 deletion including HIP1 and YWHAG identified in patients with intellectual disabilities, epilepsy, and neurobehavioral problems.
20179344 2010 Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.
20074057 2010 The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19838193 2009 Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
19626275 2009 HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits.
18790740 2008 Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
18155047 2008 Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17875735 2007 Aberrant Huntingtin interacting protein 1 in lymphoid malignancies.
17762867 2007 The NECAP PHear domain increases clathrin accessory protein binding potential.
17500595 2007 Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
17452370 2007 Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.
17440072 2007 Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.
17257618 2007 Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.
16979168 2006 Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations.
16847693 2006 Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease.
16341674 2005 Transcriptome analysis of human gastric cancer.
16320245 2006 Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy.
16169070 2005 A human protein-protein interaction network: a resource for annotating the proteome.
16027218 2005 Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.
15581353 2004 Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.
15533940 2005 Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15383276 2004 A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15122254 2004 Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
15059611 2004 HIP1: trafficking roles and regulation of tumorigenesis.
14998932 2004 Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts.
14732715 2004 HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14570852 2003 Increased expression of the Huntingtin interacting protein-1 gene in cells from Hutchinson Gilford Syndrome (Progeria) patients and aged donors.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12853948 2003 The DNA sequence of human chromosome 7.
12839988 2003 Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
12781365 2003 Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12163454 2002 Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.
11889126 2002 HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
11788820 2002 Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
11604514 2001 Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors.
11577110 2001 Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.
11532990 2001 The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
11517213 2001 HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.
11063258 2000 HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
11007801 2000 Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
10428802 1999 Transforming properties of the Huntingtin interacting protein 1/ platelet-derived growth factor beta receptor fusion protein.
10222105 1999 Recent advances on the pathogenesis of Huntington's disease.
9616134 1998 Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2).
9417924 1997 Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23.
9147654 1997 HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
9140394 1997 HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.