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Tdark Histidine triad nucleotide-binding protein 3

Hydrolyzes phosphoramidate and acyl-adenylate substrates.

Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 0.84
PubTator Score 1.78

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (21)

Disease log2 FC p
adult high grade glioma -1.100 5.7e-03
Amyotrophic lateral sclerosis -1.245 6.2e-03
atypical teratoid / rhabdoid tumor -1.500 3.7e-03
autosomal dominant Emery-Dreifuss muscul... -1.293 4.3e-02
Breast cancer 2.800 2.9e-02
ductal carcinoma in situ -1.600 2.0e-03
ependymoma -1.200 2.4e-06
glioblastoma -1.300 5.0e-03
group 4 medulloblastoma 1.100 5.7e-03
hepatocellular carcinoma 1.600 8.0e-04
invasive ductal carcinoma -1.800 4.0e-04
limb girdle muscular dystrophy 2A -1.369 9.0e-03
medulloblastoma, large-cell -1.600 5.0e-04
non primary Sjogren syndrome sicca 1.300 1.4e-02
non-small cell lung cancer -1.654 2.5e-15
osteosarcoma 1.017 3.8e-02
ovarian cancer -1.100 2.0e-03
pancreatic cancer 1.700 3.3e-02
pancreatic carcinoma 1.700 3.3e-02
psoriasis -1.200 8.8e-21
tuberculosis and treatment for 6 months 1.100 1.0e-03

Synonym

Accession Q9NQE9 B3KQ91 Q8N0Y9 HINT-3
Symbols HINT4

Gene

HINT3

PANTHER Protein Class (3)

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG

 UniProt Keyword (8)

 GO Function (2)

 GO Component (3)

 Compartment GO Term (14)

 HCA RNA Cell Line (56)

See all...

Protein-protein Interaction (11)

GCC2   UBP1   TFCP2   SMAD2   SMAD3   NUCB1   HINT1   ESS2   FBXO7   DHRS3   MID1IP1  

Gene RIF (1)

AA Sequence 

MAEEQVNRSAGLAPDCEASATAETTVSSVGTCEAAGKSPEPKDYDSTCVFCRIAGRQDPGTELLHCENED      1 - 70
LICFKDIKPAATHHYLVVPKKHIGNCRTLRKDQVELVENMVTVGKTILERNNFTDFTNVRMGFHMPPFCS     71 - 140
ISHLHLHVLAPVDQLGFLSKLVYRVNSYWFITADHLIEKLRT                                141 - 182
//

Text Mined References (14)

PMID Year Title