| Tdark | Histidine triad nucleotide-binding protein 3 |
Hydrolyzes phosphoramidate and acyl-adenylate substrates.
Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.8e-21 |
| non-small cell lung cancer | 2890 | 2.5e-15 |
| ependymoma | 4679 | 2.4e-06 |
| invasive ductal carcinoma | 2951 | 4.0e-04 |
| medulloblastoma, large-cell | 6241 | 5.0e-04 |
| hepatocellular carcinoma | 547 | 8.0e-04 |
| tuberculosis and treatment for 6 months | 409 | 1.0e-03 |
| ovarian cancer | 8520 | 2.0e-03 |
| ductal carcinoma in situ | 1745 | 2.0e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.7e-03 |
| glioblastoma | 5792 | 5.0e-03 |
| group 4 medulloblastoma | 1855 | 5.7e-03 |
| adult high grade glioma | 3801 | 5.7e-03 |
| Amyotrophic lateral sclerosis | 451 | 6.2e-03 |
| limb girdle muscular dystrophy 2A | 213 | 9.0e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.4e-02 |
| Breast cancer | 3578 | 2.9e-02 |
| pancreatic cancer | 2398 | 3.3e-02 |
| pancreatic carcinoma | 562 | 3.3e-02 |
| osteosarcoma | 7950 | 3.8e-02 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 4.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 5.7e-03 |
| Amyotrophic lateral sclerosis | -1.245 | 6.2e-03 |
| atypical teratoid / rhabdoid tumor | -1.500 | 3.7e-03 |
| autosomal dominant Emery-Dreifuss muscul... | -1.293 | 4.3e-02 |
| Breast cancer | 2.800 | 2.9e-02 |
| ductal carcinoma in situ | -1.600 | 2.0e-03 |
| ependymoma | -1.200 | 2.4e-06 |
| glioblastoma | -1.300 | 5.0e-03 |
| group 4 medulloblastoma | 1.100 | 5.7e-03 |
| hepatocellular carcinoma | 1.600 | 8.0e-04 |
| invasive ductal carcinoma | -1.800 | 4.0e-04 |
| limb girdle muscular dystrophy 2A | -1.369 | 9.0e-03 |
| medulloblastoma, large-cell | -1.600 | 5.0e-04 |
| non primary Sjogren syndrome sicca | 1.300 | 1.4e-02 |
| non-small cell lung cancer | -1.654 | 2.5e-15 |
| osteosarcoma | 1.017 | 3.8e-02 |
| ovarian cancer | -1.100 | 2.0e-03 |
| pancreatic cancer | 1.700 | 3.3e-02 |
| pancreatic carcinoma | 1.700 | 3.3e-02 |
| psoriasis | -1.200 | 8.8e-21 |
| tuberculosis and treatment for 6 months | 1.100 | 1.0e-03 |
