Tbio HIGD1A HIG1 domain family member 1A, mitochondrial

Protein Summary

Description

Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes.

Uniprot Accession IDs

• Q9Y241
• Q9UFZ2

Gene Name

• HIGD1A

Ensembl ID

• ENST00000321331
• ENSP00000319393
• ENSG00000181061
• ENST00000418900
• ENSP00000402160
• ENST00000452906
• ENSP00000398064

Symbol

• HIG1
• HIG1
• RCF1a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
virus perturbation	0.83
kinase perturbation	0.81
histone modification site profile	0.75
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.27   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 98   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.27   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0