Property Summary

NCBI Gene PubMed Count 23
PubMed Score 12.43
PubTator Score 12.28

Knowledge Summary


No data available


  Disease (3)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count P-value
psoriasis 6685 2.0e-66
Disease Target Count Z-score Confidence
Prostatic hypertrophy 9 3.008 1.5


  Differential Expression (1)

Disease log2 FC p
psoriasis 1.600 2.0e-66

Gene RIF (4)

23878241 Data indicate that hypoxia-induced gene domain protein-1a (Higd-1a) inhibits Optic atrophy 1 (Opa1) cleavage and is required for mitochondrial fusion by virtue of its interaction with Opa1.
23646141 Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
22355194 depletion of HIG1 increased gamma-secretase activation and enhanced hypoxia-induced mitochondrial dysfunction
20877624 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

VVGAMTVGMGYSMYREFWAKPKP                                                    71 - 93

Text Mined References (25)

PMID Year Title
25605899 2015 Higd1a is a positive regulator of cytochrome c oxidase.
25187353 2014 Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
23878241 2013 Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.
23646141 2013 Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22609626 2012 Facile backbone structure determination of human membrane proteins by NMR spectroscopy.
22355194 2012 HIG1, a novel regulator of mitochondrial ?-secretase, maintains normal mitochondrial function.
22342701 2012 Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex.
21856340 2011 The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
16381901 2006 The LIFEdb database in 2006.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489336 2004 From ORFeome to biology: a functional genomics pipeline.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11256614 2000 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
11230166 2001 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11076863 2000 DNA cloning using in vitro site-specific recombination.
11042152 2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
10690527 2000 Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.