Property Summary

NCBI Gene PubMed Count 2,259
PubMed Score 3140.39
PubTator Score 5115.75

Knowledge Summary


No data available


  Disease (5)

Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0


  Differential Expression (19)

Disease log2 FC p
glioblastoma 1.400 5.0e-03
astrocytic glioma 1.200 2.5e-02
oligodendroglioma 1.400 3.7e-02
osteosarcoma 1.656 1.9e-05
chronic lymphosyte leukemia -1.800 1.6e-04
Duchenne muscular dystrophy 1.570 3.1e-06
autosomal dominant Emery-Dreifuss muscul... 1.490 5.6e-03
juvenile dermatomyositis 1.970 1.3e-11
Amyotrophic Lateral Sclerosis 1.063 1.0e-04
acute quadriplegic myopathy 1.570 9.2e-05
primary pancreatic ductal adenocarcinoma 1.498 7.7e-03
breast carcinoma 1.500 6.5e-04
diabetes mellitus -1.600 4.6e-02
gastric carcinoma 1.200 1.4e-02
ductal carcinoma in situ 1.100 7.7e-04
ulcerative colitis 1.400 2.1e-10
pancreatic cancer 1.500 3.3e-03
dermatomyositis 1.600 2.0e-03
psoriasis 1.100 3.6e-49

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
651589 screening 1262 / 0 / 497 Single concentration confirmation of HIF-2a Inhibitors in a HIF-1a counterscreen in human MiAPaCa-2 Cells luciferase reporter assay

Gene RIF (2202)

27125138 High HIF1alpha expression in low glucose condition with improved anaerobic glycolysis seems to be one of the key factors in maintaining the quiescent state of CD34+ stem cells.
27001172 HIF-dependent regulation of ITGA6 is one mechanism by which sorting for CD49f (+) cells enhances cancer stem cells.
26884855 14-3-3zeta regulates HIF-1alpha production in hepatocellular carcinoma cells by directly binding to HIF-1alpha and via PI3K/Akt/NF-small ka, CyrillicB signal transduction pathway.
26882120 ENO1 was demonstrated to be up-regulated by HIF-1alpha in retinal pigment epithelial cells in response to hypoxia, without influencing VEGF secretion.
26856989 Results provided evidence for LRG1 function as a novel inducer of epithelial-mesenchymal transition and angiogenesis in colorectal cancer, which was at least partially through promotion of HIF-1alpha expression.
26846782 High HIF-1alpha expression is associated with papillary thyroid carcinoma.
26828991 Serum concentrations of HIF-1alpha (t=25.53, P<0.05) and VEGF (t=12.10, P<0.05) in early stage group were significantly higher than those in normal group.
26826385 High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.
26825709 Inactivation of HIF-1alpha impairs chemotaxis and cell adhesion to stroma, reduces bone marrow and spleen colonization, regulates cell interaction with tumor microenvironment.
26808575 Under hypoxic conditions, SIRT2 inhibition increased the ubiquitination of HIF-1alpha in a VHL-dependent manner, leading to the degradation of HIF-1alpha via a proteasomal pathway.
26801746 Suggest that the HIF-1alpha-regulated cancer metabolism pathway could be a novel target for overcoming cisplatin resistance in ovarian cancer.
26784107 Report shows that PIN1 binds to and stabilizes HIF-1alpha, consequently enhancing the angiogenesis.
26782374 Our results indicated that the HIF-1alpha G1790A polymorphism was associated with an increased susceptibility to COPD in Han subjects from Southern China.
26773503 Our results suggest that functional, hypusinated eIF5A is necessary for HIF-1alpha expression during hypoxia and that eIF5A is an attractive target for cancer therapy.
26768367 Therefore, our results support a link between PD and SIRT1/HIF-1alpha signaling, which may serve as a clue for understanding PD.
26766791 Taken together, our data suggest that constitutive HIF-1alpha protein degradation in hypoxia is absolutely ubiquitination-dependent, and unidentified E3 ligase may exist for this degradation pathway.
26760782 High HIF-1alpha expression is significantly associated with Axl and VEGF expression, and with markers of poor prognosis in this series of breast cancer.
26757928 Results demonstrate a role for HIF-1alpha methylation in regulating protein stability, thereby modulating biological output including retinal and tumour angiogenesis.
26751287 The LINK-A lncRNA activates normoxic HIF1alpha signalling in triple-negative breast cancer.
26750332 We concluded that local recurrences of SCLCs caused by overproliferation of micrometastases following RFA treatment were driven by HIF-1alpha, although angiogenesis was not the driving force in the TZ.
26739387 in hypoxic pancreatic tumors PKM2 interferes both with NF-kappaB/p65 and HIF-1alpha activation that ultimately triggers VEGF-A secretion and subsequent blood vessel formation.
26728665 High serum HIF1A levels are associated with recurrence in hepatocellular carcinoma.
26721400 Hypoxia inducible factor-1alpha (Hif1alpha), a key mediator of cellular adaptation to hypoxia, is highly expressed and active in three separate mouse models: trauma-induced, genetic, and a hybrid model of genetic and trauma-induced heterotopic ossification.
26718775 Hypoxia enhanced the endogenous HIF-1alpha protein expression.HIF-1 protein bound the putative HIF-1 response element on the uPAR promoter.
26718330 miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model, which was probably caused by the downregulation of pro-angiogenic molecules, such as VEGF and HIF-1alpha.
26717965 IHC staining of human BCa tissue supported our conclusion that the expression of HIF-1a and MDR1 was higher in chemoresistant tissue vs. chemosensitive tissue.
26707376 Resveratrol inhibited hypoxia-induced HIF-1alpha protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA and MMP2.
26707275 Our data suggest that CXCL16 induces angiogenesis in autocrine manner via ERK, Akt, p38 pathways and HIF-1alpha modulation
26702059 suggest that tumor and endothelial cell-specific HIF1alpha may have opposing roles in cancer-associated coagulation and thrombosis.
26697750 Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha-mediated transcription by increasing its protein stability.
26676934 The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2/HIF-1alpha signaling pathway.
26648580 We used cobalt chloride (CoCl2) as a hypoxia-mimetic agent and found that the expression of HIF-1a protein, CA IX mRNA and protein, is effectively upregulated, except for HIF-1a mRNA.
26647819 REST represses transcription of HIF-1alpha in prolonged hypoxia, thus contributing to the resolution of the HIF-1alpha response.
26642852 although Hif-1alpha and Hif-2alpha synergize to suppress the development of acute myeloid leukemia, they are not required for leukemic stem cells maintenance.
26637636 that vascular endothelial cell HIF signaling is necessary for development of hypoxia and pulmonary fibrosis associated pulmonary hypertension
26625311 Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha-VEGF signaling axis in mediating HER2-induced tumor angiogenesis.
26621849 Results show that metformin inhibited hypoxia-induced HIF-1alpha (HIF-1alpha) accumulation and activation, and significantly decreased oxygen consumption.
26617778 Pretreatment expression of thymidine phosphorylase/HIF-1alpha were found to predict pathologic response and outcomes in clinical stage II/III rectal cancer receiving neoadjuvant chemoradiotherapy.
26616058 Interestingly, HIF-1alpha activation markedly suppressed DCA/metformin-induced cell death and recovered the expressions of glycolytic enzymes that were decreased by two drugs.
26611735 PLD2 protein itself interacts with HIF-1alpha, prolyl hydroxylase (PHD) and VHL to promote degradation of HIF-1alpha via the proteasomal pathway independent of lipase activity.
26608793 These results demonstrate that hydroxytyrosol (HT) treatment decreases both post-hypoxic reactive oxygen species and NO levels and, consequently, HIF-1alpha accumulation. These results suggest that in renal hypoxia, HT treatment might act as an effective preventive therapeutic approach to decrease stress and to improve the adaptive response to this pathological situation.
26604208 HIF-1alpha perpetuates the interactions between rheumatoid arthritis synovial fibroblasts and T cells and B cells to induce inflammatory cytokine and autoantibody production, thus exacerbating the severity of rheumatoid arthritis
26603154 Conditional inactivation of Vegfa, Hif1a, or Epas1 in recruited and resident myeloid cells that accumulated at sites of neovascularization did not significantly reduce choroidal neovascularization or oxygen-induced retinopathy.
26600509 HIF-1alpha Pro582Ser single nucleotide polymorphisms may be correlated with type 2 diabetic nephropathy , which needs further exploration
26598706 findings define, for the first time to our knowledge, a direct regulatory pathway between ERalpha and HIF-1alpha, which might modulate hormone response in treatment
26597758 The study establishes the importance of inflammation induced HIF-1alpha in integrating two crucial components- the metabolic and immune, through reorganization of cytoskeleton.
26548925 SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1alpha
26544728 Data show that c-mdm2 proto-ocogene protein (MDM2) expression levels were correlated with hypoxia-inducible factor 1, alpha subunit (HIF1alpha) levels, necrosis and proliferation index in malignant pleural mesothelioma.
26531845 First trimester extravillous cytotrophoblasts in placentas from pregnancy terminations exhibit nuclear localisation of both HIF-1a and HIF-2a.
26529465 HIF-1alpha, stabilized during transplantation, may be able to bind the BKV promoter and enhance BKV replication. Thus, hypoxia should be considered a risk factor for the development of PVAN in kidney transplant recipients.
26528854 miR-622 overexpression mediated by the transcription factor FOXO3a decreased the invasiveness of lung tumor cells by inhibiting HIF-1alpha via inactivation of ERK signaling.
26520789 the present study demonstrates a mechanical cascade of BRMS1 suppressing cancer cell invasion through downregulating HIF-1alpha transcript and consequently reducing Snail and TWIST1 expression.
26514431 Kaiso modulates HIF1A gene expression by binding to the methylated HIF1A promoter in a region proximal to the autoregulatory HIF-1 binding site, primarily during hypoxia.
26512116 HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
26510548 We observed higher HIF1a and HIF2a expression in BA than in IHC.
26503233 anticancer effect of Evo in human colon cancer may be partly mediated by downregulating HIF-1alpha expression, which is initiated by inactivating PI3K/Akt signaling transduction though decreasing the expression of IGF-1 in colon cancer cells.
26487485 provides important insights on mesenchymal stem cell bioenergetics and proposes a HIF-based mechanism of regulation of mitochondrial OxPhos in mesenchymal stem cells
26483345 Data indicate that silencing hypoxia-inducible factor-1alpha (Hif1a ) using siRNAs reduced the expression of miR-19a in moxLDL-stimulated aortic endothelial cells (ECs).
26482024 HIF-1alpha C1772 TT genotype and CC genotype were associated with lung cancer risk, but the T allele was not. Meta-analysis.
26474388 Auraptene suppresses the progression of renal cell carcinoma cells by inhibiting mitochondrial respiration and directly targeting HIF-1alpha signaling.
26467924 Knockdown of HIF-1A and IL-8 induced apoptosis of hepatocellular carcinoma triggers apoptosis of vascular endothelial cells.
26465938 ASC proliferation was enhanced by hypoxia. HIF-1a activation, FGF-2 production, and the ERK1/2 and Akt pathway were involved in this regulatory mechanism.
26458913 there is a hypoxia response element (HRE) in the nNOS promoter, to which HIF-1alpha may bind. CoCl2 enhanced the HIF-1alpha expression and its binding to this HRE, increasing the transcriptional activity of the nNOS promoter.
26456310 Hypoxia inducible factor-alpha (HIF-alpha) plays a crucial role in coordinating the response to hypoxic conditions.
26450901 Data show that estrogen receptor beta (ERbeta) functions as a repressor of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha)-mediated NF-kappa B (NF-kB) activation.
26446654 In ARPE-19 cells[Retinal Pigment Epithelium], resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation.
26425034 HIF-1alpha stabilization under proteasome inhibition is attributed to depletion of the free ubiquitin pool. the state of the ubiquitin pool seems to be a critical factor determining the cellular level of HIF-1alpha.
26406411 Overexpression of HIF1A is associated with gastric cancer.
26402839 increased nuclear expression indicates unfavorable prognosis in renal cell carcinoma patients [review]
26395918 These results suggested that fucosterol executed its protective effects against CoCl2 induced cytotoxicity and inflammation by the inhibition of hypoxia inducible factor through PI3K/Akt pathway.
26393682 let-7 is a tumor suppressor that negatively regulates RAS, also in Ewing Sarcoma, and HIF-1alpha may contribute to the aggressive metastatic behavior of Ewing Sarcoma
26392741 The loss of HIF-1alpha by hypoxic lens epithelial cells decreases the expression of the epithelial to mesenchymal transition marker proteins without sacrificing the levels of the prosurvival protein VEGF.
26387061 HIF-1alpha contributes to dendritic cell metabolism and cytokine release in response to Aspergillus fumigatus under normoxic as well as hypoxic conditions.
26376118 The results have shown an increased expression of CD31/PECAM1 correlated to HIF-1alpha expression.
26375488 The results suggest a possible role for the oxygen-dependent protein folding process from the ER-Golgi compartment in fine-tuning HIF1a transcriptional output.
26372732 High HIF1alpha expression is associated with breast cancer.
26370982 SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-alpha Signaling
26352431 LPA stimulated interaction of CSN5 with HIF1alpha and MIF. Depletion of CSN5 mitigated the association between HIF1alpha and MIF. We suggest HIF1alpha, MIF, and CSN5 form a ternary complex that is necessary to prevent degradation of HIF1alpha under aerobic conditions
26350953 The authors detected that hypoxia induced cell apoptosis via HIF-1alpha/miR-204/BCL-2 in neuronal cells.
26350185 Inhibition of HIF-1alpha effectively decreases hypoxia-induced transcription and radiosensitizes hypoxic MG-63 human osteosarcoma cells in vitro.
26350169 Report NcoA2-regulation of the AhR-ARNT-HIF-1a interaction.
26339356 The plasmid p-HIF-1alpha RNAi can effectively and specifically inhibit HIF-1alpha expression, inhibit cell proliferation, and alter the expression of key components in the Wnt/beta-catenin signaling pathway in HCT116 cells.
26330273 melatonin suppresses HIF-1alpha accumulation and VEGF generation via inhibition of melatonin nuclear receptor RZR/RORgamma in SGC-7901 cells under hypoxia.
26323347 Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1alpha/BNIP3 signaling pathway.
26310281 High HIF1A expression is associated with Esophageal Squamous Cell Carcinoma.
26305551 Data indicate that both hypoxia inducible factor 1 alpha subunit (HIF-1alpha) and hypoxia-inducible factor 2 alpha (HIF-2alpha) play a role in the metastatic cascade in these two cell lines.
26299356 Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.
26293784 HIF1A rs11549465 (P582S), rs11549467 (A588T), and rs2057482 (C191T), and WISP1 rs2929970 (A2364G) SNPs were typed in Mexican knee osteoarthritis patients. rs11549465 plays a protective role in the loss of articular cartilage in this population.
26292663 NAT12/NAA30 plays an important role in growth and survival of glioblastoma-initiating cells possibly by regulating hypoxia response (HIF1a), levels of p-MTOR (Ser2448) and the p53 pathway.
26292288 Inhibition of HIF-1alpha or miR27a expression decreased MDR1/P-gp.
26287601 NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha and AP-1-mediated VEGFa expression
26267146 Similar to TAp73, DNp73 is stabilized by hypoxia in a HIF-1a-dependent manner, which otherwise is degraded by Siah1.
26260688 Taken together, we found that miR-338-3p directly targeted HIF-1alpha, and we provide insight into Nasopharyngeal cancer initiation and progression, possibly representing a novel therapeutic target.
26245371 crystal structures for each of mouse HIF-2alpha-ARNT and HIF-1alpha-ARNT heterodimers in states that include bound small molecules and their hypoxia response element
26239613 The results revealed that DP inhibited the expression of VEGF and HIF-1alpha through the PI3K/Akt/mTOR signaling pathway, confirming that DP may be a potential therapeutic candidate for breast cancer.
26239498 HIF-1alpha is upregulated in cell tumor of bone specimens and positively correlated with miR-210 overexpression.
26232512 HIF-1alpha as a suppressor of FUT1/2 expression, thereby regulating alpha1,2-fucosylation of cell-surface glycans
26232429 Data show that both AMPKalpha cleavage and MMP9 expression are required for Toll-like receptor 4 (TLR4)-mediated mTORC1 activation and HIF-1alpha expression.
26229077 HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype is triggered by chemotherapy
26228060 analysis of the differential dose-dependent effects of simvastatin on HIF-1alpha and BACE in cultured Alzheimer's disease cybrid cells
26223692 Serum HIF-1alpha levels appear to reflect a serious state in patients with acute decompensated heart failure.
26206147 In solid tumors, HIF-1 promotes cell survival and migration, stimulates angiogenesis, and induces resistance to radiation and chemotherapy. [review]
26205124 the levels of both miR-182 and HIF1alpha were elevated, while the expression PHD2 and FIH1 was downregulated in a mouse model of prostate cancer.
26196741 Activation of the miR-373-TXNIP-HIF1alpha-TWIST signaling axis is correlated with a worse outcome in patients with breast cancer.
26191163 Our findings indicate that miR-199a may attenuate the angiogenic potential of ESCs under hypoxia partly through HIF-1alpha/VEGF-A pathway suppression.
26187851 results suggest that TRPC6 regulates metabolism to affect HIF-1alpha stability and consequent glucose metabolism in human glioma cells under hypoxia
26187670 siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not.
26164067 HSPA2 expression increased under conditions that stimulated HIF-1alpha activity, whereas inhibition of HIF-1alpha abrogated hypoxia-induced up-regulation of HSPA2 expression
26158266 Data show that hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) is activated via an proto-oncogene protein Akt/mTOR protein signaling pathway in LCC2 and LCC9 breast cancer cells.
26150319 regulation of HIF-1alpha expression in CD4(+) T cells in hypoxia gravely relies on its transcriptional upregulation and subsequent enhanced protein stabilization.
26146622 In this review, we discuss the roles of HIF-1 in both physiological/pathophysiological angiogenesis and potential strategies for clinical therapy.
26141990 The anti-invasive activity of andrographolide in hypoxic rheumatoid arthritis fibroblast-like synoviocytes is largely mediated through inhibition of HIF-1alpha signaling.
26135626 Cancer cells that possess the capacity to normoxically overexpress HIF-1a are particularly sensitive to paclitaxel.
26124330 Based on the structure of a well-known HIF1alpha inhibitor.
26115041 Data show that patients with variant alleles (CT+TT) of single nucleotide polymorphisms (SNPs) rs2057482 in hypoxia-inducible factor 1alpha (HIF-1alpha) gene had a significantly lower recurrence risk when compared with patients with the CC genotype.
26113285 Semi-quantitative real time studies showed decreased HIF-1alpha gene expression on diabetic foot ulcer patients suggesting its possible role on the pathogenesis.
26106078 These findings show that HIF-1-dependent expression and relocalization of HK2 represent a novel mechanism by which Toxoplasma establishes its replicative niche at tissue oxygen tensions.
26094772 Results showed that HIF-1alpha overexpression promotes choriocarcinoma cell aggressiveness and metastasis through the regulation of the epithelial to mesenchymal transition through Notch signaling pathway.
26094625 Triptolide may suppress HIF1alpha through a cMycdependent mechanism in pancreatic cancer.
26091577 Increased ADMA may lead to manifestation of pulmonary hypertension phenotype in human endothelial and smooth muscle cells via the STAT3/HIF-1alpha cascade.
26088446 HOTAIR is a direct target of HIF-1a through interaction with putative HREs in the upstream region of HOTAIR in NSCLC cells. Furthermore, HIF-1a knockdown or inhibition could prevent HOTAIR upregulation under hypoxic conditions
26086098 results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha
26083752 myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha) activation of SF3B1 and SF3B1-mediated splice switching of KHK-A to KHK-C
26071969 Transplantation of HIF-1alpha transfected endothelial progenitor cells attenuates pulmonary arterial hypertension.
26066786 Data shows that the CpG dinucleotide in HIF-1a hypoxia response element is unmethylated in several embryonic tissue samples, suggesting that transactivation of HIF-1a plays a significant role in HIF-1 mediated hypoxia response during development.
26066603 Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha suggesting that Robo4 is positively regulated by HIF-1alpha under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.
26063890 Data indicate that the reduction of hypoxia-inducible factor-1alpha (HIF-1alpha) expression observed was positively correlated with phospho-mTOR protein reduction.
26059435 Taken together, these results complement our previous findings and establish bidirectional crosstalk between HIF-1alpha and TAZ that increases their transcriptional activities in hypoxic cells.
26057751 ZEB1 is a direct downstream of HIF-1alpha, suggesting a novel molecular mechanism for HIF-1alpha-inducing epithelial-mesenchymal transition and cancer metastasis.
26053625 Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor important for activating innate immune effectors, and the antimicrobial peptide LL-37 (CRAMP in mice) are key determinants of C. albicans colonization resistance.
26046764 Data suggest that the potential of anti-hypoxia inducible factor 1alpha (HIF-1alpha) targeted therapy is not a candidate for exclusive use in triple negative breast cancer (TNBC), but should be considered in all breast cancers.
26037388 microRNA-210 expression was upregulated with an association with HIF-1a overexpression in clinical human catagmatic tissues and was upregulated HIF-1a-dependently in response to hypoxia in osteoblast MG-63 cells
26010887 These findings suggest that at least part of the oncogenic effects of ERbeta2 is mediated by HIF-1alpha and that targeting of this ERbeta2 - HIF-1alpha interaction may be a strategy to treat prostate cancer.
26005855 These results suggest that HIF1-alpha and AHR integrate immunological, metabolic and environmental signals to regulate the immune response.
26002461 Protein and mRNA levels of PCBP2 were down-regulated under insulin-resistant conditions. Over-expression of PCBP2 inhibits HIF1alpha and STAT3 pathway.
25997612 The expression of CD146 and HIF1a was positively correlated with EGFR and CD31, respectively in salivary gland adenoid cystic carcinoma.
25997455 Under hypoxic conditions, HIF-1alpha can facilitate the increased expression of uPA and MMP-7 through the Wnt/beta-catenin pathway, which can promote the invasiveness of gastric cancer cells.
25993275 HIF-1alpha is associated with the malignant degree, FIGO stage, histological grade, lymph node metastasis, 5-years survival rate and recurrence rate of gynecological cancer. It may play an important role in clinical treatment and prognostic evaluation
25987665 siRNA knockdown of HIF-1[alpha] in human microvascular endothelial cells significantly reduced Ang II-induced expression of genes encoding vasoactive molecules.
25983091 The overexpression of HIF-1alpha, in serum and especially in pleural effusion, may distinguish malignancy from tuberculosis.
25976207 M410 depolymerized microtubules and downregulated HIF-1alpha protein levels in a proteasome-independent manner and reduced the mRNA of HIF-1-targeted genes in the MDA-MB-231 breast cancer cell line.
25975373 the expression levels of HIF1a, Snail and Ecadherin were correlated with clinical pathological factors in human ovarian cancer.
25974097 MTG16 co-repressor promotes degradation of HIF1alpha in lymphoblasts.
25973951 HIF-1alpha promotes radiation resistance in a cell autonomous manner
25971970 Hypoxia-induced endothelial to mesenchymal Transition is mediated by HIF1alpha through direct targeting of SNAIL.
25967708 Expression of HIH-1alpha in non-small cell lung cancer patients was related to Treg cell number and immune status.
25965573 data establish YB-1 as a critical regulator of hypoxia-inducible factor 1alpha (HIF1alpha) expression in sarcoma cells
25961573 TM9SF4 is a direct target of HIF-1alpha, down-regulated in leukemic cells by hypoxia and involved in cell adhesion.
25959252 Co-expression of HIF-1a and NBS1 in primary tumors of patients with lung adenocarcinoma correlates with a worse prognosis
25956355 HIF1a may have a role in metabolic changes in type 2 diabetes
25956243 FBXL5-mediated degradation of CITED2 leads to the activation of HIF-1 alpha.
25952368 Serum HIF1a was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. HIF1a increased with nephropathy severity.
25939381 The results suggest Tip110 is an important mediator in the cross talk between p53 and HIF-1 alpha in response to hypoxic stress.
25936862 HIF3alpha has a transcriptional regulatory function, which negatively affects gene expression by competing with HIF1alpha and HIF2alpha in binding to transcriptional elements in target genes during hypoxia. (Review)
25934477 our results demonstrate that Hif1alpha and Wnt/beta-catenin signaling pathways support leukemia stem cell function in T-cell acute lymphoblastic leukemia
25929338 Pre-treatment levels of HIF-1alpha were associated with negative clinical outcome in breast cancers treated with letrozole. Xenografts expressing HIF1A were resistant to fulvestrant.Inhibition o fits expression inhibited the RAS/MAPK/ERK1/2 pathway.
25927232 Data (including data from studies in knockout mice) suggest that adherence to and invasion of urothelium by uropathogenic Escherichia coli is significantly reduced when HIF-1alpha is stabilized and allowed to accumulate in urothelium.
25924688 Results show that HIF-1alpha potentiates BMP2-induced mesenchymal stem cells chondrogenic differentiation, inhibits osteogenic differentiation and endochondral ossification, and maintains hyaline cartilage phenotypes.
25915846 Data indicate that mutant VHL can protect HIF1alpha from SART1-dependent degradation in normoxic conditions, but this protection is lost in hypoxic settings, favoring hypoxia-dependent ccRCC proliferation.
25912138 demonstrate that transcriptional regulation of HIF-2alpha seems to be restricted to neural cell-derived tumors, while HIF-1alpha is canonically regulated at the post-translational level uniformly across different tumor forms
25904334 HIF1 regulates claudin-1 in intestinal epithelium. This regulation is important for intestinal epithelial tight junction integrity.
25896712 KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subsequent accumulation of HIF1alpha in PTEN deficient prostate tumors.
25891797 miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1alpha
25884381 DEC2 facilitates HIF-1alpha stabilization and promotes HIF-1 activation in osteosarcoma.
25874499 After the silencing of HIF-1alpha, the radiosensitivity of MCF-7 cells increased and the autophagy level decreased in response to DNA damage induced by ionizing radiation, but there was no influence on IR-induced apoptosis
25872592 In vitro analysis revealed that propranolol reduces the expression of HIF-1a in hemangioma cells in a dose- and time-dependent manner, mainly by acting on b2-AR
25872572 miR-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a-independent manner. Additionally, miR-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 and GATA6.
25869614 Data suggest expression of IGFBP1 (insulin-like growth factor binding protein 1) in hepatocytes can be regulated by carnosine, a dietary factor; carnosine down-regulates expression of IGFBP1 in Hep G2 cells; mechanism involves suppression of HIF1A.
25865369 Bacteria-derived butyrate affects epithelial O2 consumption and results in stabilization of hypoxia-inducible factor (HIF), a transcription factor coordinating barrier protection.
25863229 expression of HIF and GLUT proteins within TSCC appears to be associated with disease stage, grade, and the presence of metastases. Additional studies are needed to evaluate the diagnostic and prognostic uses of these proteins in the treatment of TSCC
25861162 significance of NF-kappaB and HIF-1alpha and their target genes VEGF, IL-1beta, and MMP-1 in Porphyromonas gingivalis and hypoxia induced periodontal inflammatory processes.
25853522 RNAi targeting HIF-1alpha significantly inhibited the expression of Glut-1 mRNA.
25844601 HIF-1alpha uniquely maintains basal expression of AQP1 and AQP5 in nucleus pulposus cells
25843954 HIF-1alpha and reactive oxygen species mediate radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells.
25833823 Aberrant STAT3 and HIF1a activity drives tumor progression in malignant peripheral nerve sheath tumors.
25830305 HIF1alpha mediates altered tumor metabolism in clear cell renal cell carcinoma
25824695 Hypoxia induces changes in the gene expression of HIF-1alpha and C/EBPalpha in bladder cancer cells.
25824382 The HIF-1a gene polymorphisms might not contribute to the development of chronic hepatitis B and HBV-related liver cirrhosis in a Chinese population.
25824146 HIF-1alpha knockdown attenuated hypoxia-induced BMP4 expression and knockdown of either HIF-1alpha or BMP4 abolished hypoxia-induced TRPC expression and basal [Ca(2+)]i.
25823824 NF-kappaB both positively and negatively fine-tuned HIF-1 in hypoxic hepatocarcinoma cells.
25816356 Study showed the expression of HIF-1alpha can regulate proliferation, cell cycle, apoptosis and invasion in human tongue squamous cell carcinoma.
25811359 our results demonstrated that upregulation of HIF-1alpha in NB promotes proliferation, migration and invasiveness via SHH signaling.
25807177 Results suggest that hypoxia-inducible factor-1alpha can positively regulate the dopaminergic phenotype through estrogen-related receptor gamma .
25805230 Simultaneous HIF-1a and HIF-2a gene knockdown attenuates acquired radioresistance in Hela cells.
25799543 Data show that SHP-1 promotes HIF-1alpha degradation under hypoxic conditions leading to a reduction in VEGF synthesis and secretion and impairing epithelial cells proliferation.
25799412 Results identified SCF as a direct target of HIF-1 in pancreatic cancer. SCF/c-kit promoted invasion and proliferation of pancreatic cancer cells and may be a new target for the treatment of pancreatic cancer.
25795259 Inhibition of the p38 mitogen-activated protein kinase (MAPK) reversed H2S mediated effects, suggesting that the p38 MAPK pathway may be involved in H2S induced HIF-1alpha/Nrf2 signalling pathways.
25778315 Abnormal expression of FOXP1 in renal cell carcinoma may create progression of tumor from low grade to high grade by regulating the HIF-1-VEGF pathway.
25761653 These findings indicate that LncRNA HIF1A-AS1 may play an important role in the pathogenesis of Cardiovascular disease , and provide a novel molecular mechanism of clopidogrel for treatment of Cardiovascular disease .
25757011 HIF-2alpha acts as an important negative regulator of hepatic lymphangiogenesis in vitro and in vivo by inducing IGFBP1.
25754303 novel pathway wherein heparanse sequentially activates integrin beta1, HIF-2alpha, Flk-1, and p38MAPK/HSP27 with corresponding enhancement of angiogenesis
25753868 miR-195 induced apoptosis in hypoxic chondrocytes by directly targeting HIF-1alpha.
25749383 Osteopontin might promote a cancer stem cell-like phenotype via the alphavbeta3-NF-kappaB-HIF-1alpha pathway in hepatocellular carcinoma.
25748238 These results suggest that low dose erlotinib-cisplatin combination exhibits its anti-tumor activity by targeting angiogenesis through the modulation of the c-MYC/HIF-1alpha/VEGF pathway in NSCLC with EGFR exon 19 deletions.
25746953 HIF1alpha is a regulator of monocyte functional re-programming in sepsis via regulating of IRAKM expression.
25745823 placental expression highest at no more than 10 weeks gestational age
25739328 expression of HIF-1alpha and CD271 in melanomas at different phases of progression, as evaluated by histology and reflectance confocal microscopy
25733830 Perpared a novel biodegradable D-alpha-tocopheryl polyethylene glycol 1000 succinate-b-poly(epsilon-caprolactone-ran-glycolide) (TPGS-b-(PCL-ran-PGA)) nanoparticle to use as a delivery system for siRNA targeting HIF-1alpha in nasopharyngeal carcinoma gene therapy.
25730867 SIRT1 signaled through a hypoxia-inducible factor-1 alpha (HIF1alpha)-dependent pathway, orchestrating the reciprocal TH1 and T(reg) lineage commitment through DC-derived IL-12 and TGF-beta1.
25725157 Chromatin immunoprecipitation analysis demonstrated binding of hypoxia-inducible factor-1alpha (HIF-1alpha) to proximal hypoxia-response element (HRE) sites within the B7-H4 promoter in multiple myeloma cells and cancer cell lines.
25717256 Suggest that HIF-1alpha and Sema4D expression correlates with histological tumor type, TNM stage, and lymphatic metastasis in colorectal carcinoma.
25710281 mRNA levels of HIF-1alpha were increased in muscle tissue of COPD patients compared to controls, which was most pronounced in the patients with high levels of muscle TNF-alpha.
25700369 Four novel variants were discovered, and a minor allele of rs11549467 was associated with the RRR of the subjects (p = 0.028). rs11549467 increases HIF-1a transactivity, enhancing angiogenesis and increasing new vessel formation.
25695729 SOCS3 negatively regulates proliferation and angiogenesis of NCI-H446 cells and that HIF-1alpha is required in this process. The results also suggested a suppressive role of SOCS3 in Akt signaling, but not STAT3 signaling to block HIF-1alpha expression
25692954 We have discovered the CEBPD- hypoxia-inducible factor-1 (HIF-1) pathway as a new HIF-1-regulating fundamental mechanism in tubular epithelial cells for the cellular protection against kidney injury.
25688508 A meta-analysis revealed that the HIF-1alpha G polymorphism might lead to susceptibility to malignant tumors, especially in European and East Asian populations.
25688362 Studied the effects of zeaxanthin on the VEGF and HIF-1alpha expression in the primary culture of human RPE cells. Hypoxia caused a significant increase of VEGF expression and accumulation of HIF-1alpha in RPE cells.
25687434 the nuclear entry of FIH-1 depends on HIF-1alpha
25663785 Review/Meta-analysis: HIF-1alpha -1790G>A polymorphism is associated with a significantly increased risk of digestive tract cancer in Asian population.
25661370 PKM2 is an active protein kinase, and promotes liver cancer cell proliferation by up-regulating HIF-1alpha and Bcl-xL expression.
25659153 Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.
25655308 Taken together, these results illustrate that, as a potent inhibitor of HIF-1alpha and Stat3 signaling, LB-1 exhibits antitumor effect and could be potentially used to treat pancreatic cancer.
25641377 Inhibition of HIF-1alpha might be a valuable strategy to optimize the efficacy and reduce the complication of trans-arterial chemoembolization.
25637186 SET9 enriches at hypoxia response elements sites of HIF-1 responsive glycolytic genes and stabilizes HIF-1alpha at these sites in hypoxia.
25623525 HIF1alpha has a role in protecting cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia
25622105 our data suggest that RBM38 is a novel translational regulator of HIF1alpha under a hypoxic condition.
25618585 HIF-1alpha expression is significantly upregulated in cyclosporine A-induced gingival overgrowth specimens. The activation of HIF-1alpha may promote fibrogenesis by an increase of PAI-1 expression and a subsequent elevation of extracellular matrix production in gingival tissues.
25615526 UCHL1 promotes metastases as a deubiquitinating enzyme for HIF-1alpha.
25611387 ING1b finely regulates the hypoxic response by triggering HIF1alpha proteasomal degradation.
25605240 Results indicate the impact of hypoxia on lipid metabolites, of which a distinct subset is regulated by hypoxia inducible factor 1 alpha subunit (HIF1alpha).
25602156 Factor inhibiting HIF1alpha (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1alpha pathway
25596742 Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2).
25596376 Report efficient delivery of HIF1alpha siRNA into tumors as part of combination therapy along with photodynamic therapy in the treatment of oral squamous cell carcinoma.
25596085 Our findings that reduced Beclin-1 and high HIF-1alpha expression are associated with the development and progression of HCC may provide molecular therapeutic targets toward inhibiting HCC development and progression.
25592037 HIF1alpha-ZEB1 signaling axis promotes hypoxia induced mesenchymal shift and invasion in glioblastoma cells.
25589622 The study establishes a link between immune selection, overexpression of HIF-1alpha, and cancer immune adaptation under normoxia
25579062 Enhancement of VEGF release in long-term drug-treated breast cancer via TRPC5-HIF1A pathway
25573093 Data suggest, in pregnancies with monochorionic twins sharing one placenta and exhibiting selective intra-uterine growth restriction, expression of HIF1A mRNA (a biomarker of oxidative stress) is up-regulated in placental share of the smaller twin.
25569379 the complex structural remodeling of the matrix might reduce oxygen availability in the valve cusp contributing to the stabilization of HIF-1alpha that in turn induces a metabolic adaptation through the upregulation of VEGF
25557012 GPX8 is transcriptionally regulated by HIFalpha and modulates growth factor signaling in HeLa cells.
25556481 For the 1772 C/T polymorphism in HIF1A, the analysis showed that the T allele and genotype TT were significantly associated with endometrial cancer risk.
25553605 review examines the role of HIF-1alpha in MM and recent developments in harnessing the therapeutic potential of HIF-1alpha inhibition in MM
25550584 High HIF-1A expression predicts poor survival in clear cell renal cell carcinoma patients.
25550463 miR-429 attenuates HIF-1 activity by decreasing HIF1A message during the early stages of hypoxia before HIF-2 is activated
25548487 HIF-1alpha may modulate vascular mimicry in esophageal squamous cell carcinoma by regulating VE-cadherin expression.
25545169 increased HMGB1 induces an extension of inflamed synovium by accelerating angiogenesis in rheumatoid arthritis through enhancement of HIF-1alpha activation.
25545166 The direct inverse association between HIF-1alpha and PIGF in serum and placental tissues may be responsible for the low oxidative stress and endothelial dysfunction, leading to the pathogenesis of preeclampsia.
25542265 PDAC specimens also showed higher expressions of PHD3 but lower expressions of HIF-1alpha
25537504 Data suggest that the mechanism of gamma-H2AX on the angiogenic activity of hepatocellular carcinoma (HCC) might go through EGFR/HIF-1alpha/VEGF pathways under hypoxic conditions.
25535359 The transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angiogenesis.
25535357 Inhibition of TAp73 results in an accumulation of HIF-1alpha and up-regulation of HIF-1alpha target genes.
25531325 The silencing of IDH3a significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis
25531114 High HIF1A expression is associated with drug resistance in hepatocarcinoma.
25520138 HIF-1alpha polymorphisms (g.C111A, g.C1772T and g.G1790A) are not associated with breast cancer risk.
25517638 Findings show that TET1 serves as a transcription co-activator that interacts with HIF-1alpha and HIF-2alpha to enhance their transactivation activity as well as INSIG1 in addition to its role in demethylating 5-methylcytosine.
25514934 Hypoxia induces autophagy in human vascular endothelial cells in a hypoxia-inducible factor 1dependent manner.
25511037 HIF-1a levels in the serum and SF were closely related to the radiographic severity of Osteoarthritis and may serve as an alternative biomarker for the progression and prognosis of knee Osteoarthritis
25510668 There is no significant association between HIF-1alpha (1772C>T) (rs 11549465) polymorphism and breast cancer development.
25510503 These results indicate that HIF-1alpha is required to restrain the NF-kappaB response, and thus prevents excessive and damaging pro-inflammatory responses.
25499970 Hispidulin sensitizes tumor cells to Gemcitabine and 5-Fluoroucil by down-regulating HIF-1A/P-gp signaling.
25498504 Taken together, these results demonstrate that NP1 gene is a target of as hypoxia inducible factor-1 alpha and it regulates NP1 expression by binding to hypoxia responsive elements in its promoter region.
25496056 This meta-analysis demonstrates that both the C1772T and G1790A polymorphisms in the HIF-1alpha gene likely contribute to increased cancer susceptibility.
25484075 HIF1A expression may be a potential new therapy to resolve Adherent invasive E. coli infection in Crohn disease patients
25484025 The present meta-analysis suggests that HIF-1alpha C1772T polymorphism is a risk factor for susceptibility to breast cancer in Asians.
25483439 Tim-3 triggers growth factor type responses in acute myeloid leukaemia cells by activating a phosphatidylinositol-3 kinase (PI-3K)/mammalian target of rapamycin (mTOR) pathway.
25460285 HIF1A and MIF as potential predictive mRNA biomarkers of pre-eclampsia
25450522 Taken together IL-10 influences the DNA binding pattern of HIF and the level of gene induction.
25450397 Hif-1Aregulates activation of hepatic stellate cell by modulating autophagy.
25447306 The HIF-1 alpha stabilization/nuclear translocation seemed related to HIF-1 activity upstream of E-cadherin signalling, that was regulated by Wwox/HDM2, while TAZ is known to be a co-factor of HIF-1.
25432699 These results suggest that PLD2 expression in colon cancer cells is up-regulated via HIF1-alpha in response to hypoxic stress and underscores the crucial role of HIF1-alpha-induced PLD2 in tumor growth.
25425478 HIF-1alpha is expressed in acute and chronic ischemic tissue, but also in normal colon tissue and inflammatory disorders.
25420025 Data show that dimethyl-2-ketoglutarate (DKG) inhibits hypoxia-inducible factor 1alpha (HIF-1alpha) proline hydroxylation and degradation mediated by prolyl-4-hydroxylase PHD2.
25418470 IL-1b, which normally bridges innate and adaptive immunity, induces the production of the major haematopoietic/proleukaemic growth factor SCF through the PI-3K/mTOR pathway and the HIF-1a transcription complex.
25412955 Positive expression of SLC2A1, SLC2A3, and HIF-1alpha genes was noted in 83.9, 82.1, and 71.7% of SCC specimens and in 34.4, 59.4, and 62.5% of laryngeal cancer samples. Higher levels of mRNA/protein for GLUT1 and HIF-1alpha were noted in SCC compared to NCM
25401740 HIF-1alpha 1790G>A polymorphism is associated with the susceptibility to CSM and can be used as predictor for the clinical outcome in CSM patients receiving ACF treatment.
25396735 HIF-1alpha depletion induced a reversal of the epithelial-to-mesenchymal transition in colon cancer cells.
25394713 deregulated GAPDH expression promotes NF-kappaB-dependent induction of HIF-1alpha and has a key role in lymphoma vascularization and aggressiveness
25391657 TRPM2-L function may be a novel approach to reduce tumor growth through modulation of HIF-1/2a, mitochondrial function, and mitophagy.
25391298 The first trimester placental tissues are not energetically compromised from hypoxia; HIF-1alpha is unlikely to play an appreciable role in regulating transcriptional activity under steady-state conditions in vivo.
25389292 PPARA activity increases the expression of miR-199a2 which in turn is responsible for reduced expression of HIF-1a and ET-1.
25385144 Our results imply that autophagy contributes to the reduction of radiosensitivity in hypoxic environment, and the process is mediated through the HIF-1alpha/miR-210/Bcl-2 pathway in human colon cancer cells
25385044 these findings indicate that the antitumor effect of F2 is, at least in part, mediated by suppressing HIF-1alpha-dependent pathway, and suggest that F2 may be a potentially useful agent for treatment of human cancer
25385028 Results defined LASP1 as a direct target gene for HIF1alpha upregulation that is critical for metastatic progression of PDAC.
25380826 PHD3 SUMOylation occurs at a cluster of four lysines at the C-terminal end of the protein. Furthermore, PHD3 SUMOylation by SUMO2 or SUMO3 contributes to PHD3-mediated repression of HIF1-dependent transcriptional activity.
25377659 HIF-1alpha high expression was correlated with node involvement, clinical stage and poor prognosis of nasopharyngeal carcinoma patients.
25361009 These observations define a novel function of PLD1 as a previously unrecognized HIF-1alpha regulator.
25355043 data suggest that Cezanne is essential for HIF-1alpha protein stability and that loss of Cezanne stimulates HIF-1alpha degradation via proteasome-independent routes, possibly through chaperone-mediated autophagy.
25351724 Vaccinia virus C16 reprogrammes cellular energy metabolism towards increased synthesis of the metabolic precursors utilized during viral replication via the stabilization of HIF-1alpha.
25349289 Results show transcriptional upregulation of HIF1a in prostate cancer stem cells (CSC) and decreased mTOR activity leading to inhibition of proliferation and promoting survival of prostate CSCs through the IRS-1/PI3K feedback loop.
25339014 Upregulation of HIF-1alpha by hypoxia protect neuroblastoma cells from apoptosis by promoting survivin expression.
25338163 Molecular dynamics of hif-1alpha and VHL may determine the success of antineoplastic strategies in hypoxia-reoxygenation as predicted by computational modeling.
25337255 Review/Meta-amalysis: HIF-1alpha P582S polymorphism may be associated with the risk of cervical cancer.
25329389 HIF1alpha signaling appears to play an important role in epithelial-mesenchymal transition after exposure to cigarette smoke
25326537 Cullins are a family of NEDD8 targets important in the stabilization and degradation of proteins, such as hypoxia-inducible factor (HIF1A), via Cullin-2.
25323032 HIF-1alpha promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells.
25318952 Data indicate that emodin attenuated the lipopolysaccharide and hypoxia/reoxygenation (HR)induced intestinal epithelial barrier dysfunction mediated by hypoxia-inducible factor 1, alpha subunit (HIF1alpha) and nuclear factor NFkappaappa B.
25314054 long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha in pancreatic ductal adenocarcinoma.
25307345 the NTR1-HIF-1alpha-VEGFalpha axis has a role in intestinal angiogenic responses and in the pathophysiology of colitis and inflammatory bowel disease
25278309 Meta-analysis suggests HIF-1alpha overexpression is significantly associated with poor prognosis in pancreatic cancer.
25271630 these results suggest that NO could regulate the expression of Tbeta4 by direct or indirect effect of HIF-1alpha on Tbeta4 promoter.
25257607 The interaction between MM cells and BM stromal cells is drastically reduced upon HIF-1alpha down-modulation.
25243117 3 biomarkers in 44 patients with in situ breast cancers were evaluated: TG2 (transglutaminase 2), HJURP (Holliday junction recognition protein), and HIF-1alpha (hypoxia inducible factor-1 alpha).
25242614 These results indicate that the HIF-1alpha expression is associated with hippocampal apoptosis, and suggest that HIF-1alpha is an important factor during epileptogenesis
25239913 results demonstrate that multiple regulatory factors, such as impaired TLR4 surface expression, increased intracellular iron, and decreased HIF-1alpha, downregulate HO-1 expression
25236742 Binge alcohol promotes acute liver injury in humans at least partly through a CYP2E1-HIF-1a-dependent apoptosis pathway.
25231285 Helicobacter pylori led to HIF-1alpha stabilization in gastric epithelial cells independently of T4SS, NF-kappaB, and MAPKs.
25231004 Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1alpha depletion or imatinib treatment.
25219592 Data show that 2-deoxy-d-glucose (2-DG) combined with methylprednisolone synergistically inhibited cell proliferation, induced cell apoptosis and cell cycle arrest via down-regulation of hypoxia inducible factor 1 alpha subunit (HIF-1alpha) and c-MYC proten.
25218350 2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating expression hypoxia-inducible factor-1 and -2.
25216080 Curcumin significantly decreases hypoxia-induced hypoxia inducible factor-1alpha protein level in HepG2 cells.
25201196 Mdm2, p53 and HIF1alpha all respond to hypoxia, and intriguingly, have distinct roles depending on the level of hypoxia
25197976 Mechanistic studies confirm the mode of action of 20(S)-Rg3, which reduces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) by activating the ubiquitin-proteasome pathway to promote HIF-1alpha degradation
25195037 HIF-1a CG and CA haplotypes might be a risk factor and a protective marker, respectively, for HBV-related HCC in a Chinese population
25187556 HIF-1 and HIF-2 directly activate the expression of AXL and GAS6/AXL signaling uses lateral activation of the met proto-oncogene (MET) through SRC proto-oncogene nonreceptor tyrosine kinase to maximize cellular invasion.
25181405 HIF and mTORC1 signalling seems active in both Basal cell carcinoma and trichoepithelioma.
25175731 Newly discovered S-sulfenylations suggested novel redox mechanisms, including S-sulfenyl-mediated redox regulation of the transcription factor HIF1A by SIRT6.
25174950 Study demonstrated that reactive oxygen species promote the migration and metastatic growth of ovarian cancer cells via upregulation of HIF-1a and LOX and E-cadherin repression.
25169545 NF-kappaB signaling is activated in Hepatocellular carcinoma and associated with disease prognosis and with high circulating levels of HIF-1 alpha.
25162518 RBP2 promotes HIF-1alpha-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
25158249 The HIF-1alpha G1790A polymorphism may increase the risk of colorectal, esophageal, gastric, and liver cancers, especially among Asian populations. (Meta-analysis)
25156689 Laboratory findings indicate stabilisation and an increased transcription activity of hypoxia-inducible factor 1 alpha (HIF1alpha), leading to up-regulation of its downstream target genes (such as vascular endothelial growth factor (VEGF).
25142304 peritoneal milky spots served as a hypoxic niche and favored gastric cancer stem/progenitor cells peritoneal dissemination through hypoxia-inducible factor-1alpha both in vitro and in vivo
25131208 Gamma-secretase can achieve temporal control of neoplasm invasion and metastasis through conditional interactions with regulatory proteins, such as Hif-1A, under select physiological and pathological conditions.
25130171 HIF-1alpha directly regulates Ob-R expression in pancreatic cancer
25120765 These findings suggest that the HIF-1alpha expressions in different cell populations of esophageal squamous cell carcinoma microenvironments have different clinical relevance and prognostic impact on patients.
25119596 High expression of HIF1alpha is closely associated with the tumor size, lymph node metastasis and perineural invasion in pancreatic cancer.
25117331 our findings suggest that HIF1A Pro582Ser polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.
25115400 We demonstrate Beclin 1-independent autophagy is involved to positively regulate nutrient deprivation induced-HIF-1alpha internal ribosome entry site activity and protein expression
25109450 irradiation reduces hydroxylation of HIF1alpha through destabilization of prolyl hydroxylases (PHD)-2 in glioma cells
25108440 Data indicate that hypoxia-inducible factor (HIF)-1alpha (HIF-1alpha) levels are raised in sera and lung tissues of chronic obstructive pulmonary disease (COPD) patients and smokers with normal lung function.
25105148 these data provide the first evidence of antiproliferative and apoptosis-inducing effects of IK as a HIF-1alpha inhibitor and suggest it may be a drug candidate for chemotherapy against oral cancer.
25103363 Pfn1 is a tumor suppressor in pancreatic cancer that acts via a novel mechanism of regulating the SIRT3-HIF1alpha axis.
25101278 We also summarized the latest findings concerning the role of HIF-1 in the development of hepatocellular carcinoma , which could shed light on new therapeutic approaches for the treatment of HCC.
25100165 The expression of both BNIP3 and IGF-2 was completely suppressed in the HIF-1alpha deficient cells. The present study demonstrates Cu-dependent and -independent HIF-1 regulation of gene expression.
25100134 Serum HIF-1alpha was identified as relevant baseline biomarker of Sunitinib activity in advanced Renal Cell Carcinoma.
25093297 HIF-1alpha is a transcription factor for PRDX3 gene expression in clear cell renal cell carcinoma.
25091694 HIF-1 promotes the expression of its alpha-subunit via an epigenetically regulated transactivation loop.
25088997 We found that HSF4 downregulation led to decrease of HIF1alpha mRNA expression
25082844 SENP1 deficiency exacerbates ischemia-reperfusion injury in cardiomyocytes via a HIF1alpha-dependent pathway.
25075425 it mediates tumor growth.
25072260 Modulation of HIF1A activity by anaesthetics may affect cancer recurrence following surgery.
25071185 Cdk1 activity blocks lysosomal degradation of HIF-1alpha and increases HIF-1alpha protein stability and transcriptional activity. By contrast, Cdk2 activity promotes lysosomal degradation of HIF-1alpha at the G1/S phase transition.
25069832 A novel role for miR-18a in targeting HIF1A and repressing metastasis of basal-like breast tumors.
25065497 our study provides a mechanistic insight into how TRPM8 promotes the hypoxic growth adaptation of cancer cells via its promotion of RACK1-mediated stabilization of HIF-1alpha
25057215 SNPs in HIF1a associate with MI, T2DM, hypertension, and dyslipidemia.
25051011 Data show that tumor necrosis factor-alpha (TNF-alpha) increased A549 lung adenocarcinoma cell permeability by repressing vasodilator-stimulated phosphoprotein (VASP) expression through the activation of hypoxia inducible factor 1 alpha subunit (HIF-1alpha).
25046225 the undetectable PHD3 could contribute to the higher HIF-alpha expression in ccRCC.
25027070 Impaired hypoxia-inducible factor regulation by hyperglycemia
25019382 Cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner.
25017254 Study demonstrated that high levels of EZH2 expression predicted poor prognosis in luminal-subtype breast cancer patients. Importantly, EZH2 and HIF-1alpha co-overexpression predicted poorer overall survival.
25012504 WWOX controls glycolytic genes' expression through hypoxia-inducible transcription factor 1alpha (HIF1alpha) regulation. WWOX, via its first WW domain, physically interacts with HIF1alpha and modulates its levels and transactivation function.
24999595 HIF-1alpha may be a key factor in cell proliferation in hMSCs and important in wound healing.
24995509 No associations appeared between HIF1A SNPs and age-related macular degeneration, which were studied here for the first time.
24994549 Enhanced autophagy was induced by the elevated level of HIF-1alpha; metastatic ability and epithelial-to-mesenchymal transition of pancreatic cancer stem cells was associated with HIF-1alpha and autophagy. This finding may indicate the specific role of HIF-1alpha and autophagy in promoting the metastatic ability of pancreatic cancer stem cells.
24984035 describe a mechanism through which hypoxia and specifically HIF-1alpha preclude cells from maintaining senescence-driven anti proliferative response
24983504 HIF-1alpha-miR-21 feedback contributes to the adaptation of cardiomyocytes to hypoxia
24981555 spermatozoa from the asthenozoospermic group presented an increased expression of IL-1beta, COX-2, and HIF-1alpha compared with the normospermic fertile subjects
24980968 Ent caused HIF-1alpha protein stabilization.
24980293 High expression of HIF-1alpha is associated with sinonasal and laryngeal small-cell neuroendocrine carcinoma.
24980197 HIF-1alpha, promotes angiogenic stimulation required for cancer development, with a resultant aggressive cell phenotype and rapid malignant progression.
24980036 study indicates HIF-1 not only regulates hypoxia-induced VEGF-A production but also mediates at least in part the effects of growth factors and dexamethasone on VEGF-A synthesis and release; findings show the complexity of VEGF-A regulation in meningiomas
24978711 Overexpression of hypoxia-inducible factor-1alpha is associated with cervical cancer.
24972968 transfecting mTOR siRNA into A549 cells significantly decreased the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and survivin
24970694 Overexpression HIF1alpha was related with higher expressions of CXCR7 and CXCR4, otherwise IDH1 mutation related with lower expression of both genes in astrocytomas.
24969897 No significant association was found between these 2 SNPs in HIF1A gene and clinical outcomes of CRC.
24966925 Rg3 exhibits anti-leukemia effect in part due to its anti-angiogenic activity via inhibiting PI3K/Akt and ERK1/2 pathways, which act to regulate the expression of HIF-1alpha and VEGF.
24952732 Data show that doxazosin inhibited the phosphorylation of VEGF receptor-2 (VEGFR-2) Akt and mammalian target of rapamycin (mTOR), and hypoxia-inducible factor 1 (HIF-1alpha) expression.
24947080 In CLI patients a significant decrease in serum HGF levels, concomitant with a loss of skin HIF-1alpha stabilization and a lack of c-Met phosphorylation were seen, probably driving a decrease in wound-healing functions.
24939299 Results suggest that nerve growth factor (NGF) and hypoxia inducible factor-1alpha (HIF-1alpha) are synergically involved in the angiogenesis of non-small cell lung cancer (NSCLC).
24938788 Exposure of human breast cancer cells to hypoxia augments microvesicle (MVs) shedding that is mediated by the HIF-dependent expression of the small GTPase RAB22A, which colocalizes with budding MVs at the cell surface.
24938129 This result shows that unliganded ERbeta is sufficient to inhibit HIF-1 in systems of overexpression.
24937673 Bladder cancer patients with high HIF1A expression had improved 5-year local relapse-free survival with chemoradiotherapy.
24931519 These results suggested that hypoxia could stimulate Foxp3 expression by increasing HIF1alpha expression in CD4(+) T lymphocytes which may promote CD4(+) T lymphocytes to convert to Treg.
24929654 In Chinese glioma patients the 1772C>T genotype TT had a higher risk of glioma than CC genotype or controls. Survival was lower in TT or CT genotypes. HIF-1alpha regulates the proliferation, migration and invasion of human glioma U251 cells.
24924632 These findings indicate that fatty acids bound to albumin play a crucial role in albumin-induced HIF-1 activation followed by changes in HIF-1 target gene expression and protein product activity.
24919196 Rb is present in HIF1alpha-ARNT/HIF1beta transcriptional complexes associated with TRIP230 as determined by co-immuno-precipitation, GST-pull-down and ChIP assays
24918449 SHARP1 interacted with HIF-1alpha physically.
24916446 this study reveals that HIF-1alpha-regulated cellular metabolic processes are negatively affected by the AhR agonist PCB 126
24916276 Studies indicate that the transcriptional activity, protein stabilization, protein-protein interactions and cellular localization of hypoxia inducible factor-1alpha (HIF-1alpha) are mainly modulated by various post-translational modifications.
24901645 HIF-1alpha inhibition reverses multidrug resistance in colon cancer cells via downregulation of MDR1/P-gp.
24898836 Training-induced negative regulation of HIF mediates the attenuation of PDK-1 and contributes to skeletal muscle adaptation to exercise.
24895585 The results suggested that the expression level of BAG3 and HIF-1 alpha is efficient prognostic parameters in patients with HCC after liver transplantation.
24886405 Berberine may inhibit the expression of HIF-1alpha and VEGF and thus confer radiosensitivity on prostatic cancer cells.
24878611 Depending on the pathological context, activation of HIF-alpha and VEGF-A signaling in renal tissue/cells may have either beneficial or harmful effects.
24868893 Rating HIF1 polymorphism did not reveal a relationship to the occurrence of ischemic heart disease in patients with obstructive sleep apnea, both in the whole group as well as separate subgroups.
24860939 knockdown of HIF-1alpha could enhance hypoxia-induced slight increase of Bax/Bcl-2 ratio and activate caspase-9 and caspase-3.
24859886 Data indicate that zinc finger protein SNAIL modulates ribosomal protein S6 kinase 1 (RPS6KB1)/HIF-1alpha/protein kinase 2 (PKM2) signaling pathway through miR-128.
24859610 HIF-1alpha silencing enhanced radiation therapy for gliomas in vitro and in vivo.
24857547 O-GlcNAcylation regulates cancer cell metabolic reprograming and survival stress signaling via regulation of HIF-1alpha.
24853275 Protein levels of HIF-1alpha were significantly increased in TACE tissues.
24850901 This study demonstrates a novel function of HIF (HIF1a and HIF2a)in regulating RNA splicing of HIF target genes
24840724 Anoxia up-regulates MUC5AC by the HIF-1alpha signaling pathway in human nasal epithelia.
24840054 Data show that the development of drug resistance described in osteosarcoma may be related to the activation of HIF-1alpha.
24835245 HIF-1alpha can be induced and activated at physiological oxygen tensions in a MAPK-dependent manner, that determines the increased cell proliferation.
24825851 Upregulated EPAS1 expression in hypoxic colorectal cancer cells that were associated with DNA demethylation of the EPAS1 regulatory region.
24824937 significant associations were found between the Hif-1/HIF-1 1790G/A polymorphism and lung cancer, pancreatic cancer and oral squamous cell carcinoma
24819156 Inherited susceptibility to increased HIF1alpha expression resulting in the up-regulation of angiogenic genes may mediate a protective effect in normal pregnancy and pregnancy complicated by late onset preeclampsia.
24818793 besides HIF-1alpha, several other pathways, including PI3K/Akt, may be involved in the response to hypoxia of immature and, more specifically, of mature DC to sustain their trafficking and functions within hypoxic microenvironments.
24812272 HIF1alpha reprograms melanomas to become highly glycolytic and dependent on glycolysis for survival.
24806027 Data suggest that hypoxia-induced expression of BOK (Bcl-2-related ovarian killer protein) in placental cells is regulated via promoter region, hypoxia-response element, and binding of hypoxia-inducible factors (HIF1A, HIF2A/EPAS1, HIF1B/ARNT).
24803010 HIF-1alpha expression is affected by anemia, although this factor has no important direct effect on the perinatal outcome.
24799675 Hypoxia-inducible factor has a role in promoting macrophage recruitment through signaling between triple-negative breast cancer cells and mesenchymal stem cells
24798801 HIF-1alpha-siRNAs abrogated EGF-induced BNIP3 but not VEGF expression.
24796659 HIF1A critically regulates HUVEC cell proliferation and migration at 21% oxygen, but not at physiologic 3% cell oxygen.
24795051 HIF-1alpha plays a major role in the survival and aggressive phenotype of retinoblastoma cells under hypoxic conditions.
24793809 HIF-1alpha is upregulated in tumor cell lines following nicotine-induced cell proliferation.
24790587 miR-210 downregulation decreased viability and induced apoptosis in hypoxic chondrocytes depending on HIF-1 alpha .
24780770 Study suggests that many of the morphological changes detected in children's brainstems regarding distributions of HIF-1alpha and MAP-2 could be due to age differences, but in some regions these distributions are more dependent on the hypoxic conditions
24769354 HIF1A rs2057482 polymorphism is involved in the risk of developing coronary artery disease and is associated with some metabolic parameters and cardiovascular risk factors.
24769203 5'-UTR-dependent up-regulation is dominant among metastatic cell lines (MDA-MB453, U87MG). It is therefore likely that the predominance of 5'-UTR-dependent translational enhancement of HIF1A is critical for the malignant phenotype of cancer cells.
24767210 HIF1A may regulate some of the gene expression and biological behavior of TGFbeta1 pathway-expressing melanoma cells, in part via alterations in miR-210, miR-218, miR-224, and miR-452
24764682 CCL2 expression correlates closely with HIF-1alpha expression in gastric cancer and may be an independent prognostic marker
24760996 Suggest that in anemia each organ expresses a different threshold for cellular HIF/NOS hypoxia responses.
24747440 In glioblastomas endothelial cell-specific Pfn-1 phosphorylation elevates HIF-1alpha expression leading to vascular abnormalities and tumor progression.
24746828 Data suggest expression of HIF1A in neuroblastoma can be regulated by dietary factors; supplementation with beta-carotene down-regulates expression of HIF1A in neuroblastoma, prevents neuroblastoma, and inhibits neuroblastoma invasion/metastasis.
24745019 Higher HIF-1alpha expression was associated with the higher risk of recurrence (P = 0.0434).
24737584 The underlying mechanism of hypoxia-upregulated lncRNA-UCA1 expression was that HIF-1alpha specifically bound to HREs in the lncRNA-UCA1 promoter
24737252 Tan IIA ameliorated hypoxia-induced DOX resistance and EMT in breast cancer cell lines, which may be attributed to the downregulation of HIF-1alpha expression.
24732040 HIF-1alpha is an important player in multiple myeloma homeostasis and that its inhibition by small antisense oligonucleotides provides a rationale for novel therapeutic strategy to improving MM treatment.
24729302 Results show that HIF-1 plays a major role in cancer cell angiogenesis, metabolic adaptation and metastasis. [review]
24726658 A physiologically relevant microenvironment of 5% O2 rejuvenates WJ-MSC culture toward less-differentiated, more primitive and faster-growing phenotypes with involvement of HIF-1a and HIF-2a-mediated and TSA-sensitive chromatin modification mechanisms.
24718784 Data shows that HIF-1alpha plays a central role in the acquisition of anti-apoptotic property in colon cancer cells under glucose deprivation.
24717944 increased expression in the nasal mucosa of patients with allergic rhinitis
24717226 Hyperthermia-conditioned olfactory ensheathing cell serum-free-conditioned medium induces neural stem cell differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
24715760 The purpose of this study was to investigate the co-expression patterns of transcription factor HIF-1alpha and von Hippel Lindau protein (pVHL) and heat shock proteins in pterygium and normal conjunctival human samples.
24711541 PML-RARalpha cooperates with HIF-1alpha to activate a pro-leukemogenic program.
24711168 nuclear HIF-1alpha was an independent prognostic parameters for progression-free survival in locally advanced rectal cancer
24706848 results demonstrate a regulatory relationship between DNM2, miR-199a, and HIF, with implications in cancer metastasis
24705306 Hif-1alpha and Hif-2alpha competitively bind to NICD.
24681946 SIRT2-mediated HIF-1alpha deacetylation is critical for the destablization of HIF-1alpha and the hypoxic response of tumour cells.
24670641 Analysis of independent cohorts of patients with triple-negative breast cancer revealed a specific XBP1 gene expression signature that was highly correlated with HIF1alpha and hypoxia-driven signatures and that strongly associated with poor prognosis.
24668884 The antagonistic effect of 15-LO1 is mediated by the Pro(564) /hydroxylation/26S proteasome system, while both the enzymatic activity and the intracellular membrane-binding function of 15-LO1 appear to contribute to HIF-1alpha suppression
24667757 FGF2 enhances formation of HIF-1 nuclear complexes via ERK pathway.
24664971 HIF-1alpha substantially influence human T cell-mediated immune responses by modulation of nT(reg)-suppressive function and IL-17A secretion by Th17 cells.
24664750 High glucose-induced, ChREBP-mediated, and normoxic HIF-1alpha activation that may be partially responsible for neovascularization in both diabetic and age-related retinopathy.
24664708 Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
24662981 These results suggested that,CypA, a gene downstream of HIF-1alpha, could promote the development of PDAC.
24662828 endogenous HIF1alpha is detectable in exosomes and that LMP1 significantly increases levels of HIF1alpha in exosomes; exosome-mediated transfer of functional pro-metastatic factors by LMP1-positive NPC cells to surrounding tumor cells promotes cancer progression
24659092 the relationship between breast cancer ultrasound synthesis diagnostic index (SDI) and the expression of MVD, VEGF and HIF-1alpha
24657063 This study identifies polymorphisms in the HIF1A and VEGF genes as potential genetic markers that indicate the predisposition to either AAA coexisting with peripheral atherosclerosis or AAA without such lesions.
24656769 HIF1alpha and HIF2alpha are required during early stages of reprogramming
24651981 High HIF1A gene expression levels were associated with lymph node metastases in advanced gastric cancer.
24648344 RHBDF1 is a critical component of a molecular switch that regulates HIF1alpha stability in cancer cells in hypoxia.
24647137 HIF-1alpha/PTEN/CD44v6/Survivin, as measured by immunohistochemistry, can be used to predict the prognosis and potential for invasion and metastasis in Asian patients with gastric cancer.
24644426 not elevated in pre-eclamptic trophoblasts
24627437 Studied a new therapeutic alternative in the treatment of multiresistant lung adenocarcinoma via siRNA-specific transfection of six crucial molecules involved in lung carcinogenesis: SFR, E2F1, Survivin, HIF1, HIF2 and STAT3.
24626950 Mutation of isocitrate dehydrogenase 1 induces glioma cell proliferation via nuclear factor-kappaB activation in a hypoxia-inducible factor 1-alpha dependent manner.
24618817 The hypoxia-HIF-1alpha-CXCR4 pathway plays a crucial role during the migration of human osteosarcoma cells, and targeting this pathway might represent a novel therapeutic strategy for patients suffering from osteosarcoma.
24614305 HIF-1alpha overexpression could be considered a useful independent prognostic biomarker in gastric cancer after gastrectomy.
24612059 Serrated colorectal carcinoma as proposed to arise from serrated adenoma is characterized by upregulation of HIF1alpha.
24610352 Stabilization of Snail by HIF-1alpha and TNF-alpha is required for hypoxia-induced invasion in prostate cancer cells.
24608455 HIF1 and its related genes are highly expressed in recurrent craniopharyngioma.
24607784 These results reveal a PHD2-mediated mechanism through which ET-1 stabilizes HIF-1alpha and HIF-2alpha pathway thereby regulating lymphatic endothelial cell behavior and lymphangiogenesis.
24599125 Fascin is a direct target gene of HIF-1a.
24599003 Results show that that nuclear CLU expression is regulated by direct binding of HIF-1alpha to hypoxia response elements sites and is epigenetically controlled by methylation of its promoter region.
24598561 Mean expression levels of hypoxia-inducible factor-1alpha were significantly higher in the cold storage groups, and lower in the machine perfusion and kidney living-related donor groups.
24590840 The expression of HIF-1alpha, at both mRNA and protein levels, was up-regulated in hippocampus and MTL cortex of mTLE patients compared with the control cortex.
24584933 overexpression of SRC-3 promoted glycolysis in bladder cancer cells through HIF1alpha to facilitate tumorigenesis, which may be an intriguing drug target for bladder cancer therapy.
24577260 HIF-alfa gene expression showed only a tendency in in chronic glomerulonephritis
24577133 Ki67 index, MVD and HIF-1 alpha index have promising prognostic value in BM and should be validated in further studies.
24576222 Meta-analysis: HIF-1alpha C1772T polymorphism most likely contributes to susceptibility to malignant tumors, especially in the American population.
24575976 Data suggest pancreatic cancer cells exhibiting high expression of HIF1A are gemcitabine-resistant; gemcitabine-resistant pancreatic cancer cells exhibit epithelial-mesenchymal transition (which is inhibited by blocking HIF1A with RNA interference).
24567056 HIF1A single nucleotide polymorphisms may have a role in prognosis of early stage non-small-cell lung cancer patients after surgery
24566861 High HIF-1A mRNA expression levels are associated with recurrence of hepatocellular carcinoma.
24564828 Elevated serum HIF-1alpha may be involved in vascular calcification in patients with type 2 diabetes mellitus.
24563687 HIF-1alpha is proline-hydroxylated at both VHL binding sites (Pro402 and Pro564), was present in hypoxic regions of a wide range of tumours, tumour xenografts and in moderately hypoxic cells
24561986 under hypoxia, expression of HIF-1alpha is induced, leading to the increase of glycolysis in BxPC-3 cells possibly through upregulation of enzymes related to glycolysis; HIF-1alpha knockdown can inhibit the prolife ratio and promote apoptosis of pancreatic cancerous BxPC-3 cells
24561118 study demonstrated that LSD1 synergized with HIF1alpha (hypoxia inducible factor-1alpha) in maintaining glycolytic process, which fueled pancreatic cancer uncontrolled proliferation
24550282 The tumor suppressor LKB1 is a central regulator of tumor metabolism and growth control through the regulation of HIF-1alpha-dependent metabolic reprogramming.
24535905 These results suggest that high HIF- 2alpha expression is associated with poor overall survival in patients with breast cancer, indicating that HIF-2alpha could be a valuable marker of breast cancer progression
24535079 These results provide molecular evidence showing that the activation of the HIF-1alpha and NF-kappaB loop is mechanistically linked with the chemoresistance phenotype of pancreatic cancer cells under hypoxic conditions
24522376 AKT-induced uptake of [(18)F]FDG was found to be HIF-1alpha independent in breast cancer cell lines.
24518827 Cyanidin-3-O-glucoside attenuates HIF-1alpha protein accumulation in hypoxic endothelial cells.
24518567 brought the first experimental evidence for the crosstalk between RET and HIF-1 that can explain the increased expression of CAIX in medullary thyroid carcinoma
24509158 These results demonstrate that the transcription factor HIF-1alpha and its important gene target VEGF can be modulated by the antioxidant enzyme EcSOD.
24507038 HIF-1alpha may promote the EMT development through regulating fibrotic gene expression during I/R injury in human renal TECs, and miR-21 could be among the important regulatory pathways in the process
24505470 HIF-1A induced PIM2 expression in HepG2 cells via binding to the hypoxia-responsive elements (HREs) of the PIM2 promoter.
24504136 Direct involvement of HIF-1alpha in the upregulation of PlGF expression in hypoxia through chromatin remodeling of hypoxia responsive elements sites
24503013 HIF-1alpha and HIF-2alpha are involved in hypoxia-induced lipid accumulation in hepatocytes via reducing PGC-1alpha mediated fatty acid beta-oxidation.
24482805 REVIEW: High expression of HIF-1alpha indicated a poor prognosis for patients with breast cancer
24475904 HIF-1alpha is associated with tumor differentiation, lymph node metastasis, and clinical stage, particularly in regard to survival in breast cancer patients.
24474252 showed that HIF-1alpha recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression
24472707 A mechanism of aromatase inhibitor resistance may be through regulation of nonhypoxic HIF-1 target genes, such as BCRP, implicated in chemoresistance. Thus, HIF-1 should be explored further for its potential as a biomarker of and therapeutic target.
24465898 The role of FIH-1 in regulating the transcriptional activity of HIF1A in glioblastoma multiforme.
24457964 Interleukin-1beta promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting HIF-1 mediated adrenomedullin production.
24457463 Expression of HIF1A was prognostic for disease-specific survival in sporadic male breast cancers (HR: 3.8, 95% CI: 1.5-9.8, P=0.006) but not within familial male breast cancer
24451260 PRMT1 is a novel regulator of HIF-1- and HIF-2-mediated responses.
24446253 HIF-1alpha gene variations are associated with the early-stage clear cell renal cell carcinoma.
24436242 Furin and PC7 siRNAs induced HIF-1alpha protein by increasing its translation, resulting in upregulation of VEGF-A.
24435707 We demonstrate a mechanism by which EGF promotes prostate cancer cell progression through a ROS/STAT3/HIF-1alpha/TWIST1/N-cadherin signaling cascade, providing novel biomarkers and promising therapeutic targets for prostate cancer cell progression.
24434214 our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha protein
24427353 the evaluation of HIF-1alpha, MT and SLUG expression in papillary thyroid carcinoma may be useful in predicting the risk of lymph node metastasis and high TNM stage.
24425105 study indicated that HIF-1alpha C1772T polymorphism was significantly associated with increased risk of malignancy development for Asians
24425001 ERRalpha can promote the hypoxic growth adaptation of prostate cancer cells via a protective interaction with HIF-1alpha, suggesting ERRalpha as a potential therapeutic target for cancer treatment.
24423936 In the Gal4 reporter systems, Sirt1 was found to repress HIF-1alpha activity constantly in ten cancer cell-lines but to regulate HIF-2alpha activity cell type-dependently.
24421387 EAF2 bound to and suppressed HIF-1alpha.
24416312 HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker
24402912 Data indicate that overexpression and knockdown of hypoxia-inducible factor 1alpha (HIF-1alpha) decreased and exacerbated, respectively, palmitic acid-induced lipoapoptosis.
24401805 Results indicate that the high expression of HIF-1alpha in venous malformation (VM) vascular smooth muscle cells under hypoxic conditions could be an important factor for stimulating downstream angiogenesis in VM.
24398102 elevated extracellular concentration of ONOO- produces an upregulation of the angiogenic factors VEGF, hypoxic-inducible factor-alpha (HIF-1alpha), and BFGF in a human corneal limbal epithelial (HCLE) cell line.
24394419 Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia.
24391213 HIF-1 plays a functional role in stretch-induced increases of ADORA2B expression and pulmonary adenosine signaling in acute lung injury. It binds to a region of the ADORA2B promoter conveying stretch responsiveness.
24390319 these results indicated that the potential of specific inhibition of HDAC2 by small molecular chemicals may lead to future therapeutic agents in human renal cancer treatment.
24386901 The results indicate for the first time that the overexpression of beta3-endonexin can decrease hypoxic induction and activation of HIF-1alpha and can prevent hypoxic endothelial proliferation and angiogenic responses.
24378640 USP8 maintains a basal expression of HIF1alpha and HIF transcriptional output in normoxia.
24374892 The association between hypoxia-inducible factor-1alpha expression and unfavorable outcome indicates the importance of using hypoxia-inducible factor-1alpha as a treatment target in hepatocellular carcinoma.
24374863 High HIF-1alpha expression correlates with apoptosis inhibition, angiogenesis and is associated with rectal carcinoma.
24374034 a highly positive correlation between PPARgamma expression and HIF-1alpha expression
24371328 These findings highlight the importance of the hypoxia-sensing pathway and HIFs in clinical hematology.
24367595 the substitution of C allele with T at HIF-1alpha gene C1772T polymorphism is a risk factor of cancer
24366872 these data support a role for LT in dysregulating HIF-1alpha and thereby disrupting homeostatic responses to hypoxia, an environmental characteristic of certain tissues at baseline and/or during disseminated infection with Bacillus anthracis.
24364919 Overexpression of miR-494 upregulated HIF-1alpha expression through activating PI3K/Akt pathway under both normoxia and hypoxia, and had protective effects against hypoxia-induced apoptosis in L02 cells.
24363272 all classes of RNA are profoundly regulated by hypoxia and implicated HIF as a major direct regulator of both the non-coding and coding transcriptome, acting predominantly through release of pre-bound promoter-paused RNApol2.
24362462 These results suggest that HIF-1a is a promising target and provide a rationale for clinical trials investigating the efficacy of the combination of topoisomerase I inhibitors and tirapazamine in hepatocellular cancers
24356968 DDT expression mirrors MIF expression in ccRCC tumor sections with high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target of HIF1alpha and HIF2alpha.
24354513 overexpression may play important role in the development of cutaneous squamous cell carcinoma
24349381 Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1alpha.
24349374 Mipu1 is involved in HIF-1-mediate cytoprotection by inhibiting the expression of Bax and interfering activation of mitochondrial apoptotic pathway.
24346287 the overall activity of HBx mutants appears to increase the expression and transcriptional activity of HIF-1alpha.
24345331 association between Ouabain and eIF4E not only raises the hope of using cardiac glycosides for cancer therapeutics more rational, but also offers a pharmacologic means for developing novel anti-cancer HIF-1alpha antagonists
24344305 JMJD5 has a role in regulating PKM2 nuclear translocation and reprogramming HIF-1alpha-mediated glucose metabolism
24344197 HIFa1 plays an essential role in the pathogenesis of renal cell carcinoma under normoxic conditions, through the loss of the Von Hippel-Lindau gene
24338218 Upregulation of HIF-1alpha gene expression is associated with retinoblastoma.
24335195 The patients with HIF1 alpha 1772CC genotype had markedly longer overall survival and progression free survival than those carrying the HIF1 alpha 1772CT and 1772TT genotype.
24333432 Experimental data revealed that inhibition of GSK3beta could increase HIF1alpha protein levels and expression of its target genes by increasing the stability of the HIF1alpha mRNA.
24324596 HIF-1alpha overexpression was significantly associated with poor overall survival of colorectal cancer patients, particularly in Asian countries, while overexpression of HIF-2alpha was only associated with grade of tumor differentiation. (Meta-analysis)
24324133 coordinated RhoA-ROCK1 expression and signaling are mediated by hypoxia-inducible factors in breast cancer cells
24316222 the existence of a positive feedback loop between HIF-1alpha and lincRNA-p21 that promotes glycolysis under hypoxia.
24297864 The HIF-1alpha protein in multiple myeloma endothelial cells may induce angiogenesis and resistance to bortezomib and lenalidomide.
24294378 HIF-1alpha and VEGF expression was dependent on the thrombus remodeling stage in cases of intravascular papillary endothelial hyperplasia.
24293391 Our findings suggest that the HIF-1alpha A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk
24260383 A significantly increased cancer risk was found in both Asians and Caucasians for HIF-1alpha 1772C/T polymorphism.
24260273 Results suggest that these missense mutations in the HIF-1alpha gene are not important for the risk of developing osteonecrosis.
24252850 miRNAs as key factors in a molecular pathway connecting Top1 inhibition and human HIF-1a protein regulation and activity, widening the biologic and molecular activity of camptothecin derivatives and the perspective for novel clinical interventions
24248265 Data indicate that ganetespib inhibited expression of HIF-1 target genes involved in against triple-negative breast cancers (TNBC) progression.
24240089 Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha expression, blunted mRNA expression of HIF-1alpha, VEGF, and the glucose transport protein Glut-1 was also observed.
24237301 IFN-gamma induced the loss of epithelial barrier function and disruption of tight junction proteins, by upregulation of HIF-1alpha expression through NF-kappaB pathway.
24232601 polymorphisms of hypoxia-inducible factor 1A HIF1A gene is not associated with pathogenesis of systemic lupus erythematosus.
24228093 Lentiviral delivery of shRNA is a promising therapeutic approach for targeting HIF-1alpha in glioma.
24227191 VEGF and PlGF regulate transcription of KCC3b and KCC4 in erythroid cells via activation of HIF-1alpha, independent of hypoxia.
24197448 Our data show that the expression of HIF-1alpha is associated with stroma remodelling processes within Papillary thyroid carcinoma
24195510 rs2057482 polymorphism of in the 3 -untranslated region of HIF-1alpha contributed to the risk of cervical cancer in a Chinese population and thus may serve as a reliable predictive factor of cervical cancer.
24189531 A phospho-mimetic construct of HIF-1alpha at Ser668 (S668E) is significantly more stable under both normoxic and hypoxic conditions, resulting in enhanced transcription of HIF-1 target genes and increased tumor cell invasion and migration.
24176785 Acute hypoxia initially stabilizes both HIF1alpha and HIF2alpha subunits by inhibiting the HIF-prolylhydroxylase-mediated degradation of HIF proteins.
24165149 HIF-1alpha expression in vulvar carcinomas was a statistically independent prognostic factor.
24164895 Data indicate the mechanism of cross talk between the protumorigenic membrane protease MT1-MMP and the signal integrator mTOR to activate HIF-1 during normoxia.
24144209 Pharmacological inhibition of prolyl hydroxylases inhibition induces HIF-1alpha-dependent cytoskeletal remodeling in endothelial cells, which is mediated essentially by a reduction in Rac-1 signaling.
24127318 Our results suggest that overexpression of HIF-1alpha affects the levels of FoxP3 in Mycosis fungoides
24123565 the findings suggest that the early induction of HIF1alpha targets may be instrumental in iPSC derivation via the activation of a glycolytic program. These findings implicate the HIF1alpha pathway as an enabling regulator of cellular reprogramming.
24120591 These findings show for the first time that the HIF-1alpha(Pro-582-Ser) polymorphism significantly affects red blood cell and iron homeostasis after blood loss, conferring to male carriers a resistance to anaemia.
24117017 when HIF-1 was activated by gene introduction or chemically, CEMP1 expression and mineralization increased.
24100543 The efficacy of inhibiting HIF-1alpha and DEC1 expression as a possible treatment for HCC should be assessed in clinical trials.
24098539 Autophagy induced by HIF1alpha overexpression supports trophoblast invasion by supplying cellular energy.
24096035 Ascofuranone inhibits epidermal growth factor induced HIF-1alpha protein expression in MDA-MB-231 cells.
24090974 Data indicate that the hypoxia inducible factor 1 alpha (HIF1a) +1772 genetic polymorphism predicts a more aggressive prostate cancer behaviour, suggesting the involvement of progression and androgen deprivation therapy (ADT) resistance.
24089028 We conclude that functional polymorphisms in the HIF-1alpha gene do not modify CAD risk but they are associated with the formation of coronary collaterals and clinical presentation of CAD
24086384 The expression of LDH-5 and hypoxia-inducible factor (HIF) 1alpha in Non-Hodgkin's lymphoma, was examined.
24086109 stabilization of hypoxia-inducible factor 1A (HIF1A) during stretch conditions in vitro or during ventilator-induced acute lung injury in vivo occurs under normoxic conditions.
24083758 up-regulated expression of HIF-1alpha protein is associated with increased multidrug resistance in laryngeal carcinoma.
24071737 Hif-1alpha stabilization drives the mesenchymal stem cells towards undifferentiated state while inhibiting osteogenic and adipogenic differentiation.
24067372 SEPT9 isoform 1 is required for the association between HIF-1alpha and importin-alpha to promote efficient nuclear translocation.
24063654 The current meta-analysis suggests that the C variant of HIF-1alpha C1772T polymorphism may increase the risk of GIT cancer, especially among Asian populations.
24058651 This study showed that overexpressed HIFs were significantly associated with increase of mortality risk. Subgroup analysis revealed that overexpressed HIF-1alpha was significantly associated with worse prognosis of HNC in Asian countries. [review]
24057269 High HIF-1alpha expression was significantly correlated with poor overall survival (OS) of gastric cancer patients.
24056783 expression of the ISG15 and/or ISGylation system attenuates HIF-1alpha-mediated gene expression and tumorigenic growth.
24046090 we conducted comprehensive search with the aim to provide an overview of studies focusing on the relationship between HIF-1a polymorphisms and cancer risk.
24042437 transcriptional associations with HIF-1alpha and NF-kappaB, as well as beta-catenin/p300 complexes, may contribute to modulation of changes in tumor cell kinetics in response to a hypoxic condition in endometrial carcinoma cells
24040331 the Mdm2-HIF1alpha axis is antagonized by serdementan, which decreases levels of glycolytic enzymes
24033233 At diagnosis, HIF-1alpha protein expression was absent in 8 out of 16 NHL patients. HIF-1alpha expression was detectable in all patients with advanced stage at recurrence. HIF-1alpha may have a role in the modifications of angiogenesis during lymphoma progression.
24022342 downregulation of miR-199a is essential for hypoxia-induced proliferation through derepressing the expression of HIF1a expression and affecting HIF1a mediated glycolytic pathway in non-small cell lung cancer progression.
24018850 HIF1A expresion was greater in small cell and squamous cell lung cancer than in non-small cell lung cancer and lung adenocarcinoma. HIF1A expression was greater in lung neoplasms than in normal lung tissue.[Review and Meta-Analysis]
24016866 Decorin may interfere with angiogenesis by downregulating hypoxia-induced Met, Rac1, HIF-1alpha and VEGF expression in RPE cells, which suggests a potential strategy for the inhibition of CNV.
24015760 There is evidence for a direct interaction between HIF-1alpha and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha.
24015181 The HIF-1alpha C1772T polymorphism T allele may increase the risk of cancer metastasis. [Meta-analysis]
24008827 HIF-1alpha was found directly bound to two hypoxia-response elements (HRE) of QSOX1 gene, both of which were required for HIF-1 induced QSOX1 expression.
23999440 HIF-1 is activated in cancer cells by tumor suppressor loss of function and oncogene gain of function and mediates metabolic alterations that drive cancer progression and resistance to therapy. [Review]
23992143 Both the VEGFR2 receptor and HIF-1alpha were expressed in alpha-SMA positive myofibroblast-rich nodules with characteristics of Dupuytren's disease in the active involutional phase.
23991975 High HIF1A expression is associated with gastric tumors.
23991178 study suggested that HIF-1alpha 1790 A > G polymorphisms may be used as a molecular marker to determine the susceptibility and severity of LDD
23991099 RNA Pol II on HIF1 or HIF2 target genes is primarily associated with HIF1alpha or HIF2alpha in a STAT3 or USF2 dependent manner
23988176 HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart--{REVIEW}
23979441 HIF-1alpha and Snail are responsible for hypoxia-induced metastasis phenotypes in pancreatic cancer.
23970362 These results suggest an HIF-1alpha-dependent regulation of MGMT expression in human pituitary adenoma cells, and HIF-1a knockdown or the HIF-1a inhibitor 2ME can confer TMZ sensitization in human pituitary adenomas.
23970191 High HIF-1alpha is associated with the development of peritoneal dissemination via natural metastatic routes in scirrhous gastric cancer
23967327 Hypoxia-inducible factor-1alpha and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis.
23966271 we explored how these HIF-specific hydroxylases contribute to the HIF-1alpha-p300 interaction by FRET measurements along with HIF-1 mediated transcriptional activation
23966163 Aurora A might be a key regulator of HIF-1alpha-promoting malignant phenotypes of hepatocellular carcinoma.
23959876 Data indicate that patients with diabetic eye disease shows that HIF-1alpha and ANGPTL4 localize to ischemic Muller cells.
23958545 the practical relevance of NF-kappaB and HIF-1alpha expression as prognostic indicators and potential targets for specific therapies deserve further investigation.
23958427 HIF-1 and HIF-2 specific gene activating functions respond differently to different stimuli.
23950980 Aberrant DLL4 expression and HIF-1alpha/VEGF angiogenesis signaling may have a role in missed abortion.
23947803 HIF-1alpha/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts.
23946285 Signaling interaction with TGF-beta promotes renal fibrogenesis in normoxia
23936170 MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1alpha in osteoblasts.
23935399 Data suggest that overexpression of HIF-1alpha, GLUT-1, and iNOS may play an important role in gastric cancer progression. GLUT-1 is a potential candidate for predicting patient survival.
23930677 TPL is able to enhance drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1alpha and Nrf2.
23928864 Ex vivo expansion protocols involving hypoxic preconditioning inhibit cell senescence in endothelial progenitor cells by hypoxia-induced hypoxia-inducible factor-1alpha-TWIST-p21 axis.
23925655 HIF-1 alpha protein is involved in transcriptional regulation of AURKA expression in breast cancer cell lines under hypoxic conditions.
23924606 The transcription of cancer-specific OATP1B3 is regulated during hypoxia through a commonly utilized pathway involving HIF-1alpha.
23920275 Overexpression of a HIF-1alpha mutant conferred resistance to cetuximab-induced G1 phase cell-cycle arrest, which could be overcome by knockdown of LDH-A expression.
23916472 Data indicate that HIG2 (hypoxia-inducible gene 2) is a HIF-1alpha target in regulating cell survival during hypoxia.
23912593 Results indicate that thioredoxin 1 is not essential for HIF-1alpha hypoxic stabilization or activity, that its overexpression can increase HIF-1alpha hypoxic activity, and that this effect is observed regardless of thioredoxin reductase 1 status.
23911400 Data indicate that transfection of HeLa cells with miR-17 and miR-20a led to an inhibition of Hif-1alpha and Hif-2alpha mRNA and protein expression and a lowered Hif DNA binding activity.
23906982 data indicate that HIF-1alpha controls sarcoma metastasis through PLOD2-dependent collagen modification and organization in primary tumors.
23900566 HIF-1alpha-induced beta-catenin activation prevented the PrP (106-126)-induced mitochondrial damage under hypoxic conditions.
23899963 Angiogenic factors VEGF, HIF-1alpha and CD34 are important in breast cancer progression and their abundance in breast tumors has prognostic and predictive value.
23897427 Data indicate that transient knockdown of BRG1 or BRM reduces hypoxia induction of several known HIF1 and HIF2 target genes in Hep3B cells.
23886708 PHD-3 mediates specific HIF1-alpha proline 567 hydroxylation, which can function as a new player in the VHL/HIF-1alpha interactions.
23886195 Increase of serum HIF-1alpha is associated with response to therapy in non- small cell lung cancer.
23886154 High HIF1A expression is associated with non-small cell lung cancer.
23886153 Elevations of HIF-1alpha expression are associated with non-small cell lung cancer.
23881929 overexpression of HIF1A is associated with metastatic clear-cell renal cell carcinoma.
23880760 These results identify KLF5 as a transactivator of HIF-1alpha and show that LPA regulates HIF-1alpha by dynamically modulating its interaction with KLF5 and p53.
23880665 the ubiquitin ligase STUB1 is required for degradation of HIF1A in the lysosome by chaperone-mediated autophagy.
23879962 Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1alpha-MUC1 pathway.
23873332 Co-transfection of HIF-1alpha siRNA and HIF-2alpha siRNA augmented downregulation of VEGF mRNA and protein in hypoxic retinal pigment epithelial cells.
23872956 Inactivation of HIF-1, by silencing its inducible alpha subunit, significantly decreases mTOR S2448 phosphorylation caused by ligand-dependent activation of human myeloid leukemia cells.
23872148 Our results show the mechanism for the cytological origin of neoplastic stromal cells in hemangioblastomas, and suggest that inhibition of the HIF pathway is an attractive strategy for the treatment of hemangioblastomas.
23870462 Overexpression of HIF-1alpha promote the proliferation, migration and differentiation of endogenous neural stem cells after intracerebral hemorrhage.
23869589 HKII is induced by HIF-1alpha and plays important roles in the proliferation and/or progression of breast carcinoma possibly through increased glycolytic activity.
23862672 This review explores the N-methyl-D-aspartate receptor and HIF1A interaction and the hypoxia connection. [review]
23857282 HIF1A polymorphisms are associated with tumor size and lymph node involvement. [Meta-analysis]
23852087 Hypoxia caused marked expression of HIF-1alpha in hepatoma cell lines.
23840849 HIF-1alpha silenced BCC were less responsive to changes in OT.
23840602 Elevated expression of HIF-1alpha was found in peri-implant tissues and synovial fluid of people with failing Metal-on-Metal hips.
23840432 HIF-1alpha and HIF-2alpha activate CD133 promoter through ETS proteins.
23838996 HIF-1alpha overexpression increased VEGF and STAT-3 expression. This was inhibited by ganetespib. HIF-1alpha knockdown inhibited VEGF and STAT-3 expression.
23836663 vaccinia virus (VACV) infection leads to a rapid stabilization of hypoxia-inducible factor (HIF)-1alpha, its translocation into the nucleus and the activation of HIF-responsive genes
23811286 PAK1 stimulates colorectal cancer cell survival by up-regulation of HIF-1alpha.
23799043 HIF-1alpha overexpression indicates a poor prognosis for patients with hepatocellular carcinoma. [Meta-analysis]
23792163 HIF1 has a role in regulating WSB-1 expression, which promotes hypoxia-induced chemoresistance in hepatocellular carcinoma cells
23791554 results provided a mechanism for communication from mitochondria to the nucleus through AMPK-HIF-1alpha.
23787140 PHD2 regulates and hydroxylates HIF-1alpha by binding to its C-terminal domain.
23785417 Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.
23778527 The increased expression of FGFR3 in bladder cancer was primarily dependent on HIF-1alpha, as knockdown of this isoform of the alpha-subunit had a stronger effect on suppressing FGFR3 levels in hypoxia.
23771673 Upregulation and maintenance of HIF-1alpha and NGF expression may attenuate VCI.
23771665 Combined detection of VM, HIF-lalpha and E-cad plays an important role in predicting the invasion, metastasis and prognosis of patients with ESCC.
23767832 No difference was observed in terms of VEGF, PIGF and HIF-1alpha in a comparison of the early- and late-onset pre-eclampsia groups.
23764844 Mitochondrial biogenesis is only indirectly regulated by p53, whose activation triggers a murine double minute 2 (MDM2)-mediated hypoxia-inducible factor 1 alpha degradation.
23760768 Through the induction of the expression of its target genes, HIF-1 coordinately regulates tissue O2 supply and energetic metabolism
23750001 Knockdown of Sirt7 led to an increase in HIF-1alpha and HIF-2alpha protein levels and an increase in HIF-1 and HIF-2 transcriptional activity.
23749907 there were no significant differences in genotypic frequencies for P582S and A588T between breast cancer patients and controls, nor between transcriptional activity of the 582S mutant and wild-type HIF-1alpha; concluded there is no association between HIF-1alpha polymrphisms and incidence of breast cancer in the Portuguese examined population
23748663 Overexpression of hypoxia inducible factor-1 alpha is assiciated with recurrence after curative resection of colorectal liver metastases
23747271 Report a new pathway of glioma radioresistance via Report the regulation of radiation-induced centrosome duplication and therefore mitotic cell death by ILK, HIF-1alpha and survivin.
23746844 Study reports that HIF1A employs a specific variant of the Mediator complex to stimulate RNAPII elongation; the Mediator-associated kinase CDK8, but not the paralog CDK19, is required for induction of many HIF1A target genes.
23744828 HIF-1alpha is a general regulator controlling the metabolic fate and multipotency of the human mesenchymal stem cells.
23732337 HIF-1alpha knockdown by miRNA decreases survivin expression and inhibits A549 cell growth in vitro and in vivo.
23728336 Data indicate the role of osteopontin (OPN) under hypoxia and in breast tumor growth and angiogenesis through NF-kappaB-mediated HIF1alpha-dependent vascular endothelial growth factor (VEGF) expression.
23727146 acute hypoxic exposure for up to 60 min does not induce a generalized inflammatory response, but does induce the expression of HIF-1a and VEGF
23723982 The HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian populations, while the A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer. [Meta-analysis]
23722539 Our results reveal how TRAF6 functions to upregulate HIF-1alpha expression and promote tumor angiogenesis.
23711352 Multiple HIF1alpha isoforms exist in peripheral blood mononuclear cells but no differences in expression were seen in rheumatoid arthritis compared with healthy controls.
23704921 Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha.
23702312 hypoxia upregulated Epac1 through HIF-1alpha induction in the CD34-immunosorted human umbilical cord blood hematopoietic stem cells
23695013 Natural fungal bioactive compound chaetoglobosin K effectively inhibits angiogenesis through downregulation of vascular epithelial growth factor (VEGF)-binding HIF-1alpha.
23674658 Studied the usefulness of (18)F-fluorodeoxyglucose FDG-PET/CT and the relationships among the expressions of HIF-1alpha, Glut-1 and VEGF, histological type, other clinical factors and FDG uptake in thymic epithelial tumours.
23671581 The inhibitory function of novobiocin in disrupting the HIF1alpha/p300 complex might be important in tumor cell growth.
23671189 CREB acts as a platform for assembling coactivators and chromatin remodelers required for MHC-I activation in a HIF-1alpha/beta-catenin-dependent manner.
23667251 HIF-1alpha promotes cap-dependent translation of selective mRNAs through up-regulating eIF4E1, which contributes to tumorsphere growth of breast cancer cells at hypoxia
23661177 Suggest oxLDL as a proangiogenic agent linking hyperlipidemia, inflammation, and angiogenesis in atherosclerosis via HIF-1alpha pathway.
23653235 HIF1-alpha and CD34 are expressed differently in esophageal squamous cell carcinoma and adenocarcinoma, suggesting different mechanisms
23649089 Staphylococcus aureus infection activates HIF-1 and causes HIF-1-dependent gene programming.
23645672 Data suggest that Keap1 does not contribute to hypoxic Nrf2 suppression, and both HIF-1alpha and Siah2 are key regulators of hypoxic responses.
23644550 hypoxia and HIF-1alpha may function in conjunction with toll-like receptor-stimulated innate immune responses to drive inflammation in rheumatoid arthritis
23639975 The present study suggests an important role of HIF-1alpha in UVB-mediated immune response in keratinocytes.
23623921 TGF-beta1 up-regulates STAT3 activation and HIF-1alpha stabilization, which leads to TWIST1 expression in a prostate cancer invasion cascade
23618863 Data indicate that menadione (MD) and ethacrynic acid (EA) decrease expression of luciferase under the control of hypoxia-responsive elements in hypoxic cells as well as to efficiently block the interaction between the full-length HIF-1alpha and p300.
23615397 Through downregulation of the nuclear transcription factors, hypoxia-inducible factor-1alpha (HIF-1alpha) and nuclear factor-kappa B (NF-kappaB).
23611775 Data indicate that both stabilization of HIF-1alpha expression under nomoxia caused by pVHL deficiency and hypoxia treatment significantly reduced SOD2 expression.
23601303 Studies suggest that hypoxia, HIF-1 alpha, PHD3 and pVHL could be considered as potential therapeutic targets for lung cancer pathogenesis and progression.
23594994 miR-199b expression level was decreased in prostate cancer while HIF-1alpha was significantly over-expressed. miR199b negatively regulated HIF-1alpha by targeting its 3'-untranslated region.
23593116 These results suggest that HIF-1alpha itself is not oncogenic but it may play an important role in lymphomagenesis.
23588703 Correlation between HIF2A and HIF1A expression and gadobutrol dynamic contrast-enhanced magnetic resonance imaging parameters Ktrans and kep in prostate cancer.
23587905 mRNA of HIF-1alpha was increased by HSA treatment. In conclusion, albumin loading induces HIF-1alpha in HK-2 cells, resulting in the increases in the expression of proteins of its target genes
23583797 1790 G/A polymorphism in the PASD8 gene played an important role in the development of cancers. [Meta-analysis]
23581228 The present finding further enriched and supported the role of HIF-1alpha expression on cell apoptosis of hepatoma cells.
23580587 Downregulation of GRIM-19 promotes HIF1alpha synthesis.
23569336 High expression of HIF1A positively correlates with tumor diameter, depth of invasion, and stage in gastric carcinoma
23567513 CCN2 in the intervertebral disc is regulated by TGF-beta and hypoxia via HIF-1alpha, the critical determinants that characterize the disc microenvironment in health and disease. (Review)
23563312 HIF1alpha and HIF2alpha activate independent transcriptional programs through SRC that promote metastasis by coordinately regulating cell invasion and ECM remodeling
23562913 HIF1alpha and PKCbeta have roles in mediating the effect of oxygen and glucose during wound healing
23551342 Melatonin as a blocker of HIF-1alpha activation could play a potential role in preventing the invasion and migration of glioblastoma cells under hypoxic conditions.
23550771 HIF-1 expression is associated with the development and progression of both astrocytic tumors and meningiomas.
23549681 Prolidase dependent HIF1A expression in breast cancer cells is induced by prolidase substrate peptides.
23545606 our study demonstrates that the hypoxia-HIF-1a, LOX-FAK/AKT pathway regulates the migration and invasion of epithelial ovarian cancer cells
23542169 RUNX3 destabilizes HIF-1alpha protein by promoting the proline hydroxylation of HIF-1alpha through binding to HIF-1alpha/PHD2
23541582 HIF-1alpha-dependent regulation of HIF-1beta is demonstrated under hypoxic conditions, when HIF-1beta is rapidly elevated on protein level.
23538299 our data show for the first time that glucose availability significantly affects the hypoxia-induced HIF-1/BNIP3 response, and in particular glucose absence results in enhancing the oxidative phosphorylation rate.
23530843 Review of the biology of regulation of HIF-1alpha, its physiological and physiopathological effects; potential diagnosis and the prognosis significance of HIF-1alpha evaluated in recent studies is also discussed.
23530034 findings reveal a negative feedback loop between CCN2 and HIF-1alpha in NP cells and demonstrate a role for CCN2 in maintaining matrix homeostasis in this tissue.
23529663 In vitro mast cell differentiation was associated with decreased CD34 expression and increased HIF1A expression.
23526997 HIF-1alpha and HO-1 levels in elderly patients undergoing non-cardiac surgery were significantly higher in the group with postoperative adverse cardiac events at each time point.
23526365 HIF-1alpha up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells.
23526216 Nickel- and PGE2-stimulated release of IL-8 from human lung fibroblasts is mediated by HIF1A.
23523960 Whereas overexpression of HIF-1alpha in MSCs was protective against cell death and apoptosis triggered by hypoxic and oxidative stress conditions, its downregulation increased apoptosis and death rate.
23517877 the expression of HIF-1alpha is closely correlated with IL-6 expression (r = 0.61 and p = 0.005), suggesting a close interaction of HIF-1alpha and IL-6 in the psoriasis immuno-microenvironment.
23513056 In both normoxia and hypoxia, pulmonary artery smooth muscle HIF-1alpha maintains low pulmonary vascular tone by decreasing myosin light chain phosphorylation.
23496980 Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1alpha in hepatocellular carcinoma.
23492195 Knockdown of HIF-2alpha and HIF-1alpha mRNA in pulmonary vascular endothelial cells decreased cell proliferation under normoxic as well as hypoxic conditions.
23485997 Rac1, HIF-1alpha, and VEGF play an important role in tumor invasion and metastasis, especially in tumor angiogenesis.
23481058 This study demonstrated a correlation between intensity of HIF-1a expression and degree of renal interstitial fibrosis.
23476056 HIF-1alpha is downregulated in the myocardium of transgenic-dominant-negative NADPH oxidase transgenic mice.
23475394 Triple point-mutants HIF1alpha effectively promoted in vivo angiogenesis in bone defect regions
23475391 our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion
23474946 Exposure of proliferative melanoma cells to hypoxic microenvironments is sufficient, in a HIF1alpha-dependent manner, to downregulate melanocytic marker expression and increase their invasive potential.
23467940 HIF-1alpha may be a dominant factor driving the metastatic progression of pancreatic cancer and can be a potent therapeutic target for the disease.
23462909 critical for constitutive expression of beta-Defensins in intestines
23462604 Serum levels of VEGF, HIF-1alpha and IGF-I were significantly higher in the diabetic patients than in the controls.
23457305 Chaperone-mediated autophagy targets hypoxia-inducible factor-1alpha (HIF-1alpha) for lysosomal degradation.
23456821 these findings support a novel model for HIF regulation in an in vitro model of human ischemia.
23454212 Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia.
23449350 In addition to HIF-1 regulating miR-210 in renal cancer, HIF-2 can regulate this microRNA in the absence of HIF-1.
23445622 DEC1 level was positively correlated with HIF-1alpha and Ki67 expression in gastric cancer.
23423382 Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
23421024 HIF1A 1772T allele enhances the Abdominal Aortic Aneurysm risk determined by smoking and promotes the development of a more complex phenotype of the disease in smokers (with coexisting severe peripheral arterial disease).
23413029 p23 recruits PHD2 to the HSP90 machinery to facilitate HIF-1alpha hydroxylation
23410250 The data of this study indicated that NSPCs have a relatively low requirement for oxidative metabolism for their survival and that hypoxic resistance is not dependent upon HIF-1alpha signaling.
23409769 Hypoxia-induced expression of TF in human breast cancer cells depends on Egr-1 and HIF-1alpha, and both of these proteins may play an important role in breast cancer metastasis, either directly or indirectly through the TF pathway.
23409121 BRCA1 and BRCA2 germline mutation-related DCIS show a high frequency of overexpression of HIF-1alpha.
23405012 HIF-1alpha inhibited firing of replication origins, decreased DNA replication, and induced cell cycle arrest in various cell types
23404377 Knockdown of Nrf2 impaired HIF1alpha signaling activation. Blockage of the FSH-ROS-Nrf2-HIF1a signaling pathway attenuated FSH-induced binding of HIF1a to the VEGF promoter.
23398456 a novel role for P-bodies in regulating HIF1A mRNA stability
23389731 study demonstrates the role and clinical relevance of miR-138 in ovarian cancer cell invasion and metastasis, providing a potential therapeutic strategy for suppression of ovarian cancer metastasis by targeting SOX4 and HIF-1alpha pathways
23388440 Elevated miR-210 expression increased survival rates along with Akt and ERK activity in human mesenchymal stem cells with hypoxia.
23387829 TCTP binds to the beta domain of VHL through competition with HIF1alpha, which promotes VHL degradation by the ubiquitin-proteasome system and HIF1alpha stability.
23381944 Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms.
23375698 Kaplan-Meier survival analysis demonstrated that HIF-1alpha and HIF-2alpha expressions were related to shortened overall survival in small cell lung cancer
23375385 HIF-1alpha could be an important factor in the onset and progression of cervical cancer and an attractive therapeutic molecular target for it.
23372804 Peroxisome proliferator activated receptor-alpha/hypoxia inducible factor-1alpha interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells.
23368766 The study of this study suggesting that impaired cytoplasmic-nuclear transport of HIF-1alpha through the nuclear pore might precede motor neuron degeneration.
23358852 Pro-EMT effect of beta-catenin in hypoxia was deprived in the absence of hif-1alpha.
23358800 It involved in the same cascade of the malignant progression of gliomas.
23344526 HIF-1alpha suppression in MM cells significantly blocks MM-induced angiogenesis and reduces MM tumor burden and bone destruction in vivo.
23342109 HIF1alpha is likely to contribute to metastasis and chemo-resistance of CRPC and targeted reduction of HIF1alpha may increase the responsiveness of CRPCs to chemotherapy.
23339102 MUC1-shRNA could inhibit proliferation and significantly weaken HIF-1alpha protein expression of QBC939 cells, suggesting its potential as a therapeutic target of CCA.
23336375 Expression of HIF-1alpha is a predictor of tumor response to neoadjuvant chemotherapy and outcome in osteosarcoma and is correlated with VEGF, APE1, and COX-2 expression.
23335846 A model in which the sustained synthesis of VEGF in lens epithelial cells, maintained under hypoxic condition, is regulated by a compensatory inter-relationship between HIF-1alpha and HIF-2alpha
23334958 Hypoxia provides two mechanisms of chondroprotection in human cartilage: inducing tissue production through HIF-2alpha and inhibiting tissue destruction mainly via HIF-1alpha.
23334242 suggest that HIF-1alpha polymorphisms enhance its target genes, thereby altering the microenvironment and supporting sequential release of inflammatory mediators or cellular events in OLP
23333658 altered expression of HIF-1 and its target genes may be associated with the pathophysiology of depression
23331791 Upregulation of HIF-1alpha appears to be a significant mechanism of resistance to antiangiogenic therapies in neuroblastoma.
23328582 findings unraveled a novel mechanism by which YY1 inhibition disrupts hypoxia-stimulated HIF-1alpha stabilization in a p53-independent manner
23326384 Data indicate an increase of VEGF, HIF-1alpha expression and microvessel density (MVD) in BRCA1-2 carriers and BRCAX compared to the sporadic control group.
23314174 A combined effect of sorafenib and radiation in response to hypoxia was shown by inhibiting angiogenesis and metastasis by suppression of HIF-1alpha expression.
23303559 Atypical osteoclast HIF-driven metabolic pathway may be an adaptive mechanism to permit rapid bone resorption in the short term while ensuring curtailment of the process in the absence of re-oxygenation.
23273913 Data show that clear cell renal cell carcinoma (ccRCC) tissue and malignant cell lines expressed higher levels of CD74 and hypoxia inducible factor 1alpha (HIF-1alpha) than adjacent normal renal tissue and normal cell HK-2.
23269488 High expression of HIF-1 is associated with squamous cell carcinoma of head and neck.
23266008 The degree of hypoxia as measured by HIF-1alpha expression does not differ between HPV positive and HPV negative cancers. The role of hypoxia in HPV negative oropharyngeal cancer warrants further investigation
23263636 Our results showed that a combination of hypoxic markers is more robust than a single marker for predicting survival in high-grade glioma.
23248117 Data indicate there was a HIF-1alpha-dependent cancer stem cell (CSC) increase in ER-alpha-positive cancers following hypoxic exposure.
23246962 pY654-beta-catenin is a critical co-factor in hypoxia-inducible factor-1alpha signaling and tumor responses to hypoxia.pY654-beta-catenin accumulates and associates with HIF1alpha and Src in human lung adenocarcinomas.
23237807 The results revealed c-Myc-dependent regulation of HIF-1alpha instead of HIF-1alpha-dependent c-Myc regulation for the first time.
23228635 High expression of hypoxia-inducible factor 1 alpha is associated with nasopharyngeal carcinoma.
23225420 HIF-1alpha overexpression indicated unfavourable prognosis and could serve as an additional prognostic factor in neuroendocrine breast cancer.
23222085 Our study provides evidence for the association between the HIF1A gene Pro582Ser polymorphism and elite strength athlete status.
23221556 These results show that Kaposi's sarcoma-associated herpesvirus ORF34 binds to HIF-1alpha, leading to its degradation via the proteasome-dependent pathway.
23220088 delta-catenin overexpression in prostate cancer CWR22Rv-1 cells results in increased HIF-1alpha and VEGF expression
23196386 Knockdown of E2F1 stabilized HIF-1alpha and promoted LOX expression, while knockdown of both E2F1 and HIF-1alpha prevented the up-regulation of LOX
23194660 data in the present study suggest that the accumulations of HIF-1alpha and HIF-2alpha by JNK and ERK are involved in different levels of arsenite-induced biphasic effects
23185562 The hypoxia-mediated HIF-1alpha-dependent up-regulation of NRP-1 is a critical molecular event involved in the vasculogenic mimicry and tumor formation by fibrosarcoma cells in vivo.
23185316 these findings show for the first time a direct link between TG2, NF-kappaB, and HIF-1alpha, demonstrating TG2's important role in cancer progression.
23181555 Report down-regulation of HIF-1a within sarcoid granulomas.
23161568 High HIF1alpha is associated with melanoma growth.
23160373 HIF-1alpha's role in tumorigenesis
23160040 Transfection of cDNA expressing stable form of HIF-1alpha reversed the increased TfR1 expression and iron uptake. These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1
23144758 Data indicate that inhibition of Nox4 expression inhibited the transcriptional activity of VEGF through HIF-1.
23144690 Data indicate that hypoxia-induced reactive oxygen species affect hypoxia inducible factor-1 alpha stabilization.
23144021 hypoxia and stabilization of HIF-1alpha result in up-regulation of differentiated embryo chondrocyte-expressed gene 1, loss of MiTF, and absence of MiTF binding to the IL-8 promoter, which in turn leads to up-regulation of IL-8 gene expression.
23142284 Role for HIF-1alpha in mediating the effects of EGF on Snail, Slug and E-cadherin expression as well as invasiveness in human ovarian cancer cells.
23131565 This report is the first study demonstrating that HIF-1alpha-mediated SP1 expression regulates PrPc transcription, and upregulation of SP1 induced by HIF-1alpha plays a key role in protection from prion-mediated neurotoxicity.
23097160 The membrane permeable Fe2+-specific chelators could enhance HIF-1alpha accumulation by proline hydroxylase 2 inhibition.
23096096 all skin biopsies from scleroderma patients were strongly HIF-1alpha reactive, compared with rare immunoreactivity observed in normal skin.
23093058 After exposure to hypoxia, HIF-1alpha protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1alpha mRNA showed no significant change
23087365 Hypoxia-inducible factor 1 gene expression is a key indicator of tumor progression in patients diagnosed with squamous cell laryngeal cancer.
23084780 The hypoxia response element site at -65 in the MUC5AC promoter and the HIF-1alpha are the major regulators for the cellular response against hypoxia in human bronchial epithelial cells.
23082126 Lactate, the end-product of glycolysis, inhibits prolylhydroxylase 2 activity and activates HIF-1 in normoxic oxidative tumor cells but not in Warburg-phenotype tumor cells.
23065205 This case control study aims to investigate the role of HSP90 Gln488His (C > G), HSP70-2 P1/P2, HIF-1 alpha C1772T and HSPA8 intronic 1541-1542delGT polymorphisms as potential risk factors and/or prognostic markers for breast cancer.
23065176 Our results demonstrate that low dose CoCl2may protect cells against irradiative harm by two mechanisms, namely HIF-1alpha expression and ROS clearance.
23063455 Metabolic features of renal cancer are linked to VHL loss. VHL loss and the ensuing increase in the expression of hypoxia-inducible factor affect several metabolic pathways, including glycolysis and oxidative phosphorylation. [Review Article]
23060442 Endorepellin affects angiogenesis by antagonizing diverse VEGFR2-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1alpha and VEGFA and concurrent inhibition of NFAT1 activation.
23059786 Hypoxia-inducible factor 1 alpha downregulates the expression of miR-17 and miR-20a that reduced c-Myc expression.
23059773 High mRNA expression of HIF1-alpha is associated with non-small-cell lung cancer.
23053140 Our data do not support the use of HIF-1alpha determined during treatment as a biomarker to predict outcome after fractionated irradiation.
23052192 Hard-metal (WC-Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1alpha, HMOX1, and p53 activation in human peripheral blood mononucleated cells.
23047702 data strongly support an important role of the vascular endothelium in determining whole-organ glucose metabolism and indicate that HIF-1alpha is a critical mediator of this function
23042446 combined variant genotypes of rs2057482 and rs11549467 were associated with increased prostate cencer risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles).
23042279 HIF-1 expression in hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve axons.
23038967 There was a direct correlation between the concentrations of beta-endorphin and HIF-1alpha in patients with acute leukemia
23034156 Data suggest that, in preeclampsia, HIF1a is overexpressed in placenta which results in upregulation of sFLT-1 (soluble vascular endothelial growth factor receptor-1), sENG (soluble endoglin), and endothelin-1. [REVIEW]
23030583 Decreasing expressions of HIF-1alpha, Bcl-2 and Ki-67 were observed during chemoradiotherapy of recel cancer, whereas GLUT-1 overall was unchanged.
23029528 Hypoxia induced adipogenic or asteogenic differentiation of human mesenchymal stromal cells is dependent on HIF1-alpha.
23028920 HIF1A was expressed in NSCLC in lung tissue from uranium miners but less in small cell lung cancer.
23028863 HIF-1alpha expression can be used as a prognostic marker and predictor of postoperative radiotherapy response.
23023480 hypoxia may increase CXCR4 activity in gastric cancer cells by activating HIF-1alpha, thereby resulting in increased migratory ability
23020605 The results confirm the significant association between HIF-1alpha and VEGF expression and suggest that HIF-1alpha expression is a favorable prognostic factor in patients with DLBCL treated with rituximab.
23013270 These data demonstrate that up-regulation of the anti-apoptotic protein Bcl-xL in NHL cells correlates with HIF-1alpha expression and activity, through which a phenotype of chemoresistance is induced.
23008060 HIF-1alpha expression was low in classic, but high in pleomorphic lobular breast cancers
23001680 The results obtained show that, like DFO, apo-LF performs as a normoxic mimetic of hypoxia, capable of stabilizing HIF-1alpha.
22992985 hypoxia downregulates the expression of cell surface MICA without increasing the level of soluble MICA in a HIF-1alpha-dependent manner.
22991450 The current study demonstrates that HIF1A Pro582Ser polymorphism has an effect on DN, possibly by conferring a relative resistance to the repressive effect of glucose on HIF-1alpha.
22986049 HIF-1alpha mediates prostate enlargement under inflammatory conditions.
22977664 HIF-1alpha may be helpful marker in evaluation of upper tract urothelial carcinoma , espec-ially when combined with angiogenesis and apoptosis.
22977270 this study unveiled a signaling axis of HIF-1alpha/miRNA-210/iron-sulfur cluster scaffold protein in a subset of head and neck paragangliomas that could have an impact on SDHB protein stability by a mechanism independent of succinate dehydrogenase mutations
22971010 Nitric oxide and reactive oxygen species produced endogenously by human colon carcinoma HCT116 cells are responsible for HIF-1A accumulation in hypoxia.
22970168 The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells.
22964004 HIF-1alpha up-regulation is dependent on intracrine PGE2-RARbeta signalling.
22960198 synergetic pathways of IL-17A and hypoxia might contribute to the migration and invasion of rheumatoid arthritis synoviocytes by up regulating the expression of MMP2 and MMP9 by activation of the NF-kappaB/HIF-1alpha pathway
22952674 Hypoxia-inducible factor-1alpha regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene
22948784 results showed that ESM-1 is significantly overexpressed, which is regulated by HIF-1alpha in colorectal cancer (CRC) patients, and can be used as a potential biomarker and a therapeutic target for CRC
22948410 results suggest that HIF-1alpha acts as an important transcription factor and can significantly affect the secretion and adhesion functions of leukemia bone marrow stromal cells.
22946320 The frequency of Pro582-->Ser allele of HIF-1alpha gene is significantly higher in athletes involved in sports.
22946054 PHD2-mediated hydroxylation of HIF-1alpha predominantly occurs in the cell nucleus and is dependent on very dynamic subcellular trafficking of PHD2.
22945272 increased expression correlated to expression of progranulin protein in villous trophoblast cells in cases of preeclampsia and fetal growth restriction
22937154 Our data identified HIF-1alpha as a regulator of CD44 that increased the number of CD44 molecules and the percentage of CD44 positive cells expressing variant exons v6 and v7/8 in breast cancer cells under hypoxic conditions.
22936443 Systematic approach to the current literature on immunohistochemistry evaluation of HIF-1alpha expression in endometrial carcinoma. Review.
22932900 activation of PPARalpha suppresses hypoxia-induced HIF-1alpha signaling in cancer cells, providing novel insight into the anticancer properties of PPARalpha agonists.
22931643 Hyperbaric oxygenation combined with As(2)O(3) can increase the expression of caspase 3 mRNA and decrease the expression of HIF-1a and VEGF mRNA in K562 cells.
22927657 hypoxia-inducible factor-1alpha (HIF-1alpha) has a radiation protective effect on human oral squamous cell carcinoma cell lines
22926943 role of Hif1-alpha in the pathology of renal cell carcinomas
22926560 Our results establish a mechanistic linkage between 2 critically important molecules in cancer, identifying CD24 as a critical HIF-1alpha transcriptional target and biologic effector
22925504 Data suggest that survivin expression in up-regulated following induction of HIF1A by cellular hypoxia in cervical cancer cells possibly leading to tumor formation and possibly to tumor progression.
22924616 Show that the administration of melatonin inhibits tumor growth and blocks tumor angiogenesis in mice. Moreover, melatonin diminished the expression of the HIF-1alpha protein within the tumor mass during tumorigenesis.
22924580 The inhibition of HIF-1alpha expression by MNP loaded with HIF-1alpha siRNA (MNP(siHIF)) blocked PC3 cell proliferation.
22918951 TTP-driven HIF-1alpha mRNA stabilization is crucial for cell migration.
22914908 The presence of the TT and GA variants of HIF 1A were associated with lymph node metastasis, while the presence of the TT variant can be associated with larger tumor size in squamous-cell carcinoma of the glottic larynx
22910906 JNK2 regulated nucleolin expression and might in turn stabilize hif-1alpha mRNA.
22908229 a novel biological consequence upon HIF1alpha-p300 interaction, in which HIF1alpha can be stabilized by p300 via Lys-709 acetylation.
22894905 HIF1alpha acts as a tumor promoter in stromal cells but as a tumor suppressor in cancer cells.
22883454 Insulin may promote the local invasion and metastasis of pancreatic cancer by up-regulating HIF-1alpha.
22873764 HIF-1alpha increased cell adhesion and migration and plays crucial role in mesenchymal stem cell biology.
22872060 Ethanol is able to enhance arsenic-induced tumor angiogenesis in colorectal cancer cells via the HIF-1alpha pathway.
22869720 MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
22865883 analysis of coordinated action of hypoxia-inducible factor-1alpha and beta-catenin in androgen receptor signaling
22865452 Findings suggest the HIF-1/PDK3 bioenergetic pathway as a new target for therapeutic intervention in metastatic melanoma.
22860423 Prolyl hydroxylase domain-containing proteins may be involved in the process of hypoxic pulmonary vascular remodeling in chronic obstructive pulmonary disease via regulation of HIF-1alpha gene expression.
22848707 activation of the aerobic glycolytic pathway, corresponding to the Warburg effect, occurs in EBV-transformed lymphoblastoid cells, in contrast to mitogen-activated B-cells
22843905 panel consisting of moderate/strong expression of CA IX, positive HIF-1alpha expression and negative/weak GLUT-1 expression in operative samples and negative/weak ezrin expression in biopsies was associated with 47.5-fold risk of death from this disease
22843691 Hypoxia-inducible factor-1alpha (HIF1alpha) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release
22831955 Overexpression of HIF-1alpha is associated with hepatocellular carcinoma.
22825513 In our study, TT and AA genotypes of C1772T and G1790A hypoxia inducible factor-1alpha single nucleotide polymorphisms were associated with the development of pancreatic cancer.
22823210 HIF-1alpha is significantly upregulated in lung during allergic response.
22820662 Germ cell tumors of the testis, regardless of the histologic type, are characterized by consistently low HIF-1alpha protein overexpression.
22800355 HIF-1alpha may promote the expression of GLUT-1 and VEGF in laryngeal carcinoma, which promotes tumor angiogenesis, invasion, and metastasis.
22781303 The present study is the first to demonstrate the increased expression of HIF1alpha in patients with shock
22753248 Overexpression of HIF-1alpha attenuated the inhibitory effects of UVA irradiation on the stemness of human adipose tissue-derived mesenchymal stem cells.
22749322 Report increased expression of HIF-1alpha and Bcl-2 in varicocele and varicose veins and increased Bcl-2 expression especially in the endothelium under hypoxia.
22745382 results demonstrated that JMJD2B was induced under hypoxia in an HIF-1alpha-dependent manner in colorectal cancer cells
22738198 HIF-1alpha mediates the extracellular antimicrobial activity of mast cells by increasing the formation of mast cell extracellular traps
22736026 Data suggest that a combination of beta-elemene with HIF-1alpha inhibitor might be a useful therapeutic option for osteosarcoma.
22728164 These studies underline the importance of mTOR as a fundamental regulator of HIF-1 signalling in myeloid cells.
22707412 Dihydrotestosterone induced HIF-1alpha expression in male human umbilical vein endothelial cells.
22684029 Differential HIF-1 transcriptional activity under mild or severe oxidative stress results from altered HIF-1alpha/p300 binding.
22673574 enhanced HIF-1alpha translation as molecular mechanism in HIF-2alpha knockdown (k/d) cells
22659133 The HIF-1 activation in the absence of WRN involves the generation of mitochondrial reactive oxygen species since SkQ1, a mitochondrial-targeted antioxidant, and stigmatellin, an inhibitor of mitochondrial complex III, blocked increased HIF-1 levels.
22647679 The C1772T polymorphism causes activation of HIF-1alpha as a gain-of-function mechanism driven by stabilization of HIF-1alpha mRNA.
22645302 HIF1 mainly binds to the intergenic regions distal from transcriptional starting sites under both normoxia and hypoxia.
22644784 IL-1beta can induce DEC1 and HIF-1alpha protein levels in gingival epithelial cells. We also demonstrate that the increase in DEC1 protein subsequently is followed by Akt phosphorylation.
22632108 Results suggest that HIF-1alpha is a vital biomarker for predicting the progression and prognosis of myelodysplastic syndromes (MDS).
22628316 action of HIF-1alpha on TMPRSS6 promoter activity
22622799 analysis of the effect interstitial fluid pressure on hypoxia-inducible factor (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human osteosarcoma xenografts in SCID mice and in different hypoxic environments
22615960 we present here data suggesting that p21 and hif1alpha mRNA plasma expressions may be used as markers for complicated pregnancies
22614155 The expression of nuclear HIF-1alpha was correlated with CD133.
22614004 Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.
22613607 While affected by HIF-1, HO-1 up-regulation promotes the expression of HIF-1 and the down-regulation of HO-1 suppresses the expression of HIF-1 gene.
22593272 hypoxia up-regulates the gastrin gene in AGS cells by HIF-independent mechanisms
22581642 demonstrate WASF3 is a HIF1A-regulated gene and suggests a mechanism to explain the observation of elevated expression of WASF3 in advanced stage tumors
22571395 HIF-1alpha was increased significantly in patients with neuroblastoma associated with unfavourable characteristics
22569265 Data suggest that vasohibin inhibits cell proliferation of umbilical vein endothelial cells through degradation of HIF-1alpha via proline hydroxylase during oxidative stress.
22558480 Case Report: HIF- 1alpha, WT-1 and VEGF are possible protagonists in the development of bilateral primary angiosarcoma of breast.
22537539 Data indicate that the invasion potencies were decreased more in ZnSO4-treated cells than in control cells after siRNA-mediated knockdown of hypoxia-inducible factors HIF-1alpha and/or HIF-2alpha.
22537386 Study finds that UBXN7 over-expression converts CUL2 to its neddylated form and causes the accumulation of non-ubiquitylated HIF1alpha.
22516347 Data show that growth arrest-specific 6 (GAS6) and receptor tyrosine kinase Axl is colocalize with hypoxia-inducible factor-1alpha (Hif-1alpha) in both primary tumors and bone metastasis in prostate tumor tissue microarrays samples.
22510688 Cancer cells after surviving radiation acquire HIF-1 activity and translocate towards tumour blood vessels.
22505354 identified hypoxia and HIF-1 as novel regulators of S100A8/A9 expression in prostate cancer. S100A9 might be useful as prognostic marker for prostate cancer recurrence after radical prostatectomy
22504483 studies identify adenosine-elicited stabilization of Per2 in the control of HIF-dependent cardiac metabolism and ischemia tolerance and implicate Per2 stabilization
22490291 Omi/HtrA2 expression is inversely correlated with HIF-1alpha expression in hepatocellular carcinoma.
22479397 Data suggest that HIF-1alpha and SIRT1 proteins interact in hepatocellular carcinoma (HCC) cells and that HIF-1alpha is a target of SIRT1 deacetylase activity.
22477004 Urinary HIF-1alpha levels were elevated in LN patients and were associated with histologic chronicity changes and renal function, indicating that HIF-1alpha might contribute to histologic chronicity in LN.
22476163 Frequency of the HIF1A Pro/Ser genotype (32.28 vs. 18.91%; p = 0.006) and Ser allele (16.93 vs. 10.00%; p = 0.01) were significantly higher in the rowers compared with those in controls.
22475487 HIF-1alpha directly bound to hypoxia-responsive element located at -419 to -414 of ARC gene, which is essential for HIF-1-induced expression.
22474076 HIF-1alpha binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke
22470546 HIF-1alpha accumulation is critical for sustaining human allergic effector cell survival and function.
22470047 As a critical mediator in vasculogenic mimicry formation, high expression of HIF-1alpha was associated with vasculogenic mimicry and tumor progression in gallbladder carcinoma patients.
22467238 studies identify HIF1alpha as a key protein in regulating transcription of XPA in lung cancer cell lines and primary tumors contributing to cisplatin resistance
22455137 The expression of both HIF-1alpha and VEGF were not significantly increased in BNIP3 positive clear cell renal cell carcinoma in comparison with BNIP3 negative tumors.
22450315 the increased NO levels in hypoxic HEK293 cells help stabilize HIF-1alpha.
22444690 Elevated HIF-1alpha expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy.
22441426 The results show that HIF1A may influence the degree of branching in the human coronary tree.
22435731 study demonstrated that the formation of cancer stem cell-like cells undergoing process of epithelial-mesenchymal transition-like associated with overexpression of HIF-1alpha, both of which are regulated by miR-21
22432008 HIF-1 alpha is stabilized in proximal tubule cells during ischemia and unexpectedly in late reperfusion, when oxygen tension is normal.
22426121 HIF1alpha exerts a negative control over beta-cell differentiation
22415309 our study establishes IGFBP3 as a direct HIF-1alpha target gene and that polysome enrichment of IGFBP3 mRNA may permit continuous translation under hypoxic conditions
22411794 CAV1 is a direct transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the formation of caveolae, leading to increased dimerization of EGF receptor.
22409847 HCV core protein enhances the expression of HIF-1alpha and VEGF in Huh7.5.1. cells.
22406979 ADM up-regulated the protein expressions of HIF-1alpha through down-regulation of proline hydroxylase (PHD) mRNA expression and PHD activity.
22406644 polymorphism at on chromosome 11q13.3 modulates the binding and function of hypoxia-inducible factor at a transcriptional enhancer
22399808 findings identified HIF-1 and NOX2 as partners acting in concert to promote angiogenesis in response to U-II
22376255 Digoxin is a potent inhibitor of HIF-1alpha signaling pathway and blood vessel formation in C4-2 castration-resistant prostate tumors.
22367210 HIF-1alpha regulation is microtubule-independent, and likely contributes to the chemoresistant nature of renal cell carcinomas.
22351759 Runx2 stabilizes HIF-1alpha by binding to ODDD to block the interaction between von Hippel-Lindau protein and HIF-1alpha.
22350022 Overexpression of HIF-1a was found to be an indicator of poor prognosis for patients with gastric cancer and was significantly correlated with histology, depth of invasion, VEGF, and MVD.
22349311 results suggest that exposure to nicotine could mimic effects of hypoxia to stimulate HIF-1alpha accumulation and activity that might underlie the high metastatic potential of lung cancer
22345328 the higher expression of HIF-1alpha and MT in varicocele and varicose veins than in the control group; MT overexpression in the muscle layer of both diseased vessels and especially located in the endothelium
22341926 Taken together, our study provides the evident of the function of HIF-1alpha/MMP-1 in regulating metastasis of bladder cancer
22340517 Hypoxia suppresses esophageal carcinoma cell migration and invasion through hypoxia inducible factor-1 alpha activation.
22323302 role in nasal polypogenesis via induction of epithelial-to-mesenchymal transition
22323068 The role of matrix metalloproteinases (MMPs), hypoxia-inducible factor-1alpha (HIF), and vascular endothelial growth factor (VEGF) in the hypertrophied ligamentum flavum, was investigated.
22320863 a novel TNF-alpha/HIF-1alpha/VASP axis in which HIF-1alpha acts downstream of TNF-alpha to inhibit VASP expression and modulate the adhesion and proliferation of breast cancer cells
22320429 Although HIF-1 alpha expression is a common finding in adenoid cystic carcinomas, it cannot be used as a marker of tumour aggressiveness.
22318330 Linear regression analysis revealed no correlation between basal HIF-1alpha levels and the survival fraction at either 2 or 4 Gy in all tumor cell lines investigated.
22308027 soluble ErbB4 intracellular domain promotes HIF-1alpha stability and signaling via a novel mechanism.
22306363 Data indicate that intracellular prostaglandin E(2) increases HIF-1alpha expression and mediates all-trans-retinoic acid (ATRA)-induced hypoxia-inducible factor-1alpha (HIF-1alpha) up-regulation.
22302938 visceral adipose tissue from human obese subjects is characterized by high levels of HIF1alpha and low levels of SIRT2
22297543 [review] Apart from traditional oxygen dependent HIF regulation, the focus on studies of HIF activity has now shifted from ischemic injury toward oxygen independent regulation in a cell specific manner.
22287060 High HIF-1alpha is associated with ovarian cancer invasiveness
22286099 Data show that the tumour suppressor protein LIMD1 acts as a molecular scaffold, simultaneously binding the PHDs and VHL, thereby assembling a PHD-LIMD1-VHL protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1alpha.
22277691 Exposure of varicose veins to hypoxic conditions was associated with increased expression of HIF-1alpha and HIF-2alpha protein and HIF target genes.
22277676 Report distinctive response patterns of HIF-1alpha, CYP3A4 and CYP3A7 to cobalt chloride in human fetal liver cells.
22266372 PRMT5 probably promotes tumor growth by stimulating cell proliferation and by participating in the construction of a tumor-favorable microenvironment via HIF-1 activation.
22258630 Data indicate that chronic HIF-1alpha stabilization drives autonomous pathways that add to progression of heart disease.
22258474 High HIF1-alpha is associated with small cell lung cancer.
22252496 Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta
22219185 These results identify FHL proteins as negative regulators of HIF-1 activity, which may provide a mechanism by which they suppress tumor growth.
22216344 2012 May 16 (10:49) ONL001859171 J Mater Sci Mater Med. 2012 Jan;23(1) 22 0 0 0
22214699 HIF-1alpha might reduce proliferation and survivin expression in primary human osteoblasts independently from cellular hypoxia. HIF-1alpha promoted the loss of the characteristic osteoblastic marker, osteocalcin in vitro.
22209974 Results suggest that FOXO3a and HIF-1alpha may be considered to be important prognostic markers in nasopharyngeal carcinoma.
22199327 Carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 have roles in disease outcome in rectal cancer
22199311 the mTOR-HIF-1alpha-VEGF pathway affects the progression of oral squamous cell carcinomas
22194599 inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3 by decorin
22193962 The results indicate a role of HIF-1alpha in skin homeostasis especially during epidermal aging.
22192476 HIF-1alpha-mediated upregulation of fibrogenic growth factors induced by ligation of Kalpha-1T antibodies is critical for development of fibrosis leading to chronic rjection of lung allografts.
22190738 down-regulation of the deregulated HIF-1alpha blocks Hsp90alpha secretion and invasion of the cells
22186139 our findings uncover a previously uncharacterized regulatory relationship between Myc and HIF1 that has important implications for cancer metabolism and development.
22178822 When the monochorionic twin placenta is formed in the early period, HIF-1alpha, VEGF and VEGFR-1 are over-expressed, which may affect the placenta angiogenesis and induce twin-twin transfusion syndrome.
22172637 HDAC7 reduction in COPD causes a defect of HIF-1alpha induction response to hypoxia with impaired VEGF gene expression. This poor cellular adaptation might play a role in the pathogenesis of COPD.
22170854 Liquiritigenin inhibits serum- and mimicked hypoxic-induced HIF-1alpha protein accumulation in HeLa cells.
22157238 Inflamed ileum of Crohn disease patients abnormally expressed HIF-1a.
22153809 In non-smallcell lung cancer higher odds ratios for lung cancer were observed for individuals with HIF-1a-1772 T/T genotype against CC/CT genotypes, and HIF-1a-1790 A/A genotype against GG/GA genotypes.
22152691 Angiogenesis and the expressions of CD82 and HIF-1alpha are related to differentiation, lymph node metastasis and clinical staging in non-small cell lung cancer.
22151618 we have demonstrated that HIF-1alpha and HSP90 play an important role in the tumorigenesis of papillary thyroid carcinoma
22144179 A new pathway that could be targeted at the level of GSK-3, Fbw7, or USP28 to influence HIF-1alpha-dependent processes like angiogenesis and metastasis.
22135724 HIF-1alpha may regulate the expression of EPO, which plays a favorable regulatory role in the proliferation and survival of human first-trimester trophoblast cells and decidual stromal cells
22132102 This analysis reveals a surprising cancer cell line specific variation of HIF activity in the same level of hypoxia.
22128293 Data suggest that conditions that mimic hypoxia increase vascular endothelial growth factor (VEGF) expression via HIF-1a and decrease stromal cell-derived factor-1 (SDF-1) expression in HIF-1a-independent manner in endometrial stromal cells.
22128162 ubiquitin-specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1alpha and rescues it from degradation independent of its catalytic activity
22126773 CoCl(2) dose- and time-dependently increases the expression of HIF-1alpha, and significantly inhibits the proliferation of HL-60 cells.
22114151 HIF-1alpha increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter
22104200 Constitutive activation of signal transducers and activators of transcription 3 correlates with better prognosis, cell proliferation and hypoxia-inducible factor-1alpha in human gastric cancer.
22094081 Activation of the HIV-1 LTR by HIV-1 Vpr is HIF-1alpha dependent
22093255 Non-metal binding hypoxia mimetics, and hypoxia inhibit TNFalpha-mediated VCAM-1 expression via HIF1a/2a mechanism in endothelial cells.
22090111 HIF-1alpha and HIF-2alpha induce transcription of Kaposi's sarcoma-associated herpesvirus LANA.
22087807 LiPopolySaccharides induces the nuclear accumulation of HIF-1alpha in human gingival fibroblasts and induces HIF-1 biologic activity under normoxia or hypoxia possibly through TLR4.
22086197 sequential activation of two transcription factors, HIF and Sp1, is required to stimulate transcription of Abcc8 following cerebral ischemia.
22086003 Hypoxia increased HIF-1alpha and iNOS expression in HaCaT cells and inhibition of HIF-1alpha expression decreased iNOS expression.
22073864 High glucose activates HIF-1alpha mediated gene expression regulation in glomerular mesangial cells, which causes diabetic nephropathy.
22058032 By allying with HIF1alpha, RORgammat wins the fight against FoxP3 and Treg cell commitment.
22050843 HIF1-mediated GATA1 up-regulation promotes erythropoiesis in order to satisfy the needs of an organism under hypoxic conditions.
22041818 YC-1 inhibits HIF-1alpha and HIF-1alpha-mediated gene expression, cell proliferation and migration activity and induces apoptosis in hypoxic bladder transitional carcinoma cells.
22037472 HIF1alpha activity is diminished in 14q-deleted kidney cancers, and all somatic HIF1alpha mutations identified in kidney cancers tested to date are loss of function.
22037464 This study identifies RhoE as a direct target for HIF-1 in gastric cancer cells.
22036844 HIF-1alpha may be involved in the pathogenesis of prion-related diseases and as such may be a therapeutic target for prion-related neurodegenerative diseases.
22023789 These findings indicate that activation of the HIV-1 LTR by Vpr is HIF-1alpha dependent.
22023789 Activation of the HIV-1 LTR by HIV-1 Vpr is HIF-1alpha dependent
22020939 CCN5-induced inhibition of TWIST1 expression is mediated through the translational inhibition/modification of hypoxia-inducible factor-1alpha via impeding JNK signaling pathway
22009797 RSUME critically regulates HIF-1a and VEGF-A production and thus might play an important role in pituitary tumour neovascularisation
22006996 Findings show a link between hypoxia-induced accumulation of HIF-1alpha, increased expression of ADAM10, and decreased surface MHC class I chain-related molecule A levels leading to tumor cell resistance to lysis mediated by innate immune effectors.
22004076 The overall results point towards a novel ability of HDM2 in regulating HIF-1alpha and p-STAT3 levels even in normoxic conditions that eventually lead to an up-regulation of VEGF expression.
22000259 The study pointed out the direction for further research to find indicators for tumor invasiveness and the possibility of practical use of HIF-1a as important methods for determining changes in laryngeal cancer
21985026 HIF-1alpha immunoreactivity in substantia nigra neurons is significantly increased in five of six patients with restless legs syndrome, compared with controls.
21980400 Study demonstrated that hypoxia-induced HIF-1alpha expression involves a cascade of signaling events including ROS generation, activation of PI3K and ERK signaling, and subsequent activation of Rac1.
21979130 genetic association studies in population in Republic of Korea: Data suggest that two SNPs in HIF1A (1722C>T/Pro582Ser; 1790G>A/Ala588Thr) are not associated with pre-eclampsia in the population studied.
21970364 HIF-1-mediated VLDLR induction influences intracellular lipid accumulation through regulating LDL and VLDL uptake under hypoxia.
21966417 downregulation of HIF-1 through EGFR signaling seems to be required for the induction of a positive response to EGFR-targeted therapies in TNBC
21964756 data introduce a new mechanism for regulation of HIF-1alpha during hypoxia that utilizes phosphorylation to target HIF-1alpha for ubiquitin-dependent degradation through FBW7 and may identify new targets in the regulation of angiogenesis
21959987 Hypoxia-induced migration of HSC/MFs involves an early, mitochondrial-dependent ROS-mediated activation of ERK and JNK, followed by a delayed- and HIF-1alpha-dependent up-regulation and release of VEGF.
21959110 Studies indicate that HIF-1alpha, CAIX and VEGF were expressed in OSCC.
21949677 Findings suggest that hypericin may potentially be useful in preventing growth of tumors in which HIF-1alpha plays pivotal roles.
21945343 The present study shows that the HIF-1alpha G1790A polymorphism and its protein expression have an impact on the prognosis of upper aerodigestive tract carcinoma patients
21945026 variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia
21944175 Hypoxic pulmonary hypertension is closely associated with increased expression of HIF-1alpha and VEGF in high altitide areas.
21938405 anterior cruciate ligament cells responded to hypoxia by up-regulating the HIF-1alpha expression significantly as compared to medial collateral ligament cells
21926263 loss of epithelial barrier integrity by oxidative stress is minimized by activation of HIF-1, in part by induction of sestrin-2
21925591 The antiangiogenic and anti-inflammatory effects of EC-SOD might be due to suppression of hypoxia-inducible factor-1alpha expression.
21922147 HIF-1alpha enhanced neo-microvascularity in a hypoxic environment and increased drug resistance in pancreatic cancer
21922131 HIF-1alpha contributes to epithelial to mesenchymal transition and chemoresistance induced by hypoxia
21917920 HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia
21911388 Metastatic niche formation is an HIF-1-dependent event during breast cancer progression
21910893 Results show carbonic anhydrase 9 (mRNA and protein), and HIF-1alpha protein are overexpressed in a significant portion of WTs.
21908555 A constitutively activated human HIF1alpha, (P402A, P564A, N803A) in mouse proximal tubule cells is sufficient to promoter cell proliferation, angiogenesis, genomic instablity & other phenotypic changes of Von Hippel Lindau disease.
21897117 Antisense transcripts are activated in response to different kinds of stress. 5'aHIF-1alpha accumulates at the perinuclear cellular compartment and colocalizes with nuclear pore complex Nup62 protein.
21896985 HIF-1alpha was associated with the presence of metastases at time of diagnosis and time of relapse. HIF-1alpha is likely to play a role in progressive prostate cancer.
21887310 hypoxia or overexpression of HIF-1alpha induces the epithelial to mesenchymal transition that is largely dependent on NF-kappaB in pancreatic cancer cells
21881486 Tumor size, HIF-1alpha, and phos-S6 expression were found to be independent predictors of both DSS and tumor progression in primary clear cell renal cell carcinomas.
21880716 the mechanisms for galectin-1 expression regulation and HIF-1alpha- and C/EBPalpha-induced leukemic cell differentiation.
21876459 There is no association between HIF1-a and PlGF in any melanoma type. Hypoxia, in the expression of HIF1-a, plays a key role in melanoma progression; it activates VEGF secretion, which induces angiogenesis and metastasis. Role of PlGF seems to be limited.
21875287 miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of clear cell renal cell carcinoma cells.
21860410 inhibition of HIF-1 activity in BrCa cells inhibits primary tumor growth and metastasis of BrCa cells to the lungs by blocking expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM);ANGPTL4 inhibits endothelial cell(EC)-EC interaction; L1CAM increases the adherence of BrCa cells to ECs
21859818 HIF-1alpha mutants were more effective for enhancing angiogenesis in ischaemic muscle tissue than wild-type HIF-1alpha.
21856910 Upregulation of COX-2 and HIF-1alpha in response to hypoxia is suppressed by dihydrotestosterone via an androgen receptor-independent mechanism.
21846590 Increased HIF1alpha expression may contribute to the increase in glycolytic flux and lactate production in pyruvate dehydrogenase complex deficiency.
21843314 High HIF-1alpha is associated with angiogenic potential in human small cell lung carcinoma.
21841824 in the first stages of clear cell renal cell carcinoma formation the stabilization of HIF-1alpha dominates, limiting proliferation, as the HIF-2alpha ratio increases, a more aggressive cell behavior emerges
21840486 study indicates that the KLHL20-mediated PML degradation and HIF-1alpha autoregulation play key roles in tumor progression
21824412 Hypoxia, as indicated by HFI-1alpha expression, might be related to the worse prognosis found in CD44+CD24-/low positive breast tumors.
21824245 Taken together, these findings identify HIF-1alpha as responsible for upregulation of Mcl-1 and the maintenance of apoptosis resistance during Chlamydia infection.
21822544 HIF-1alpha overexpression significantly promoted hemorrhagic transformation in pituitary adenoma
21819559 Suggest the possible involvement of Hif-1alpha/PDGF-BB pathway in the development of HIV-1 associated pulmonary arterial hypertension.
21819559 Activation of the HIV-1 LTR by HIV-1 Vpr is HIF-1alpha dependent
21818118 Hypoxia-inducible factor-1alpha (HIF-1alpha) induced activation of Notch pathway is essential for hypoxia-mediated maintenance of glioblastoma stem cells.
21813290 Data suggest that the levels of HIF-1alpha and NF-kappa-B transcription factors in vitreous humor are not increased in proliferative diabetic retinopathy.
21813166 HIF-1alpha is overexpressed in bladder tissue and VEGF is overexpressed in umbrella cells from patients with interstitial cystitis
21807897 Data suggest that miR-155 induction contributes to an isoform-specific negative-feedback loop for the resolution of HIF-1alpha activity in cells exposed to prolonged hypoxia, leading to oscillatory behavior of HIF-1alpha-dependent transcription.
21807114 HIF-1alpha possesses a MAPK docking domain; this finding provides a link between the MAPK signaling cascade and the hypoxia-induced signaling pathway and their possible roles in tumorigenesis.
21802218 HIF-1alpha may play a role in the early stage of breast carcinogenesis.
21799876 cross-talk of signalling pathways associated with HIF-1 activation
21796840 The serum HIF-1alpha has high expression in PHC. The serum HIF-1alpha expression has close relation with the whether distant metastasis of tumor.
21779800 DEC1 expression is correlated with HIF-1alpha protein in gastric cancer cell line.
21778785 Compared with normoxia, hypoxia elevated the expression of CD133, CXCR4 and HIF-1alpha. Moreover, hypoxia facilitated the invasiveness of CD133+ pancreatic cancer cells.
21778301 VHL and HIF1A polymorphisms may not influence renal cell carcinoma (RCC) susceptibility but may jointly influence RCC progression and survival.
21775632 TTP physiologically controls the expression of a panel of HIF-1alpha target genes. These data reveal a new role for TTP in the control of gene expression during the response of endothelial cell to hypoxia.
21773947 GDF-15 promoted angiogenesis in hypoxic HUVECs possibly through inhibiting p53 signal, which subsequently enhanced and stabolized HIF-1alpha expression, and up-regulated the related downstream angiogenic signaling.
21765619 we speculate that the effects of hypoxia are not due to HIF-1, but are caused by the activation of NFkappaB
21763962 Studies indicate that HIF transcriptionally activates several genes implicated in clear-cell RCC pathogenesis, including VEGF.
21751260 Data show that MT2-MMP was a novel hypoxia-responsive gene and was upregulated by HIF-1alpha under hypoxia.
21746877 our fi ndings reveal a direct link between cyclin E and HIF-1 activities in mammary epithelial cells and implicate HIF-1 as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers.
21733372 Cell inflammation reaction and apoptosis induced by HIF-1alpha may participate in the mechanism of hypoxia inducing low endometrial receptivity.
21732131 FIH-1 expression does not seem to explain the proposed functional differences between diffuse and perinecrotic HIF-1alpha expression in breast cancer.
21712445 Findings show that the combination of intratumoral HIF-1alpha, VEGF, and MMP-2 may be useful as a molecular prediction model for LNM.
21709439 the C1772T and G1790A single nucleotide polymorphisms in the HIF-1 alpha gene increase the susceptibility to pancreatic cancer.
21703345 protein stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells
21698228 Parvovirus B19 infection of primary human erythroid progenitor cells at hypoxia is regulated by STAT5A and MEK signaling but not HIFalpha.
21693763 show that the perpetual EMT driven by chronic hypoxia depends on HIF-1alpha induction of genetic alterations rather than its canonical transcriptional activator function
21685944 It was shown that beta-arrestin1 robustly interacts with nuclear HIF-1alpha and potentiates HIF-1alpha-dependent transcription of vascular endothelial growth factor-A.
21674552 ANGPTL4 is a target gene of HIF-1alpha and acts as an important regulator in the metastasis of hepatocellular carcinoma.
21672245 HER2-related breast tumors with high hypoxia, as well as normal basal epithelial cells, express increased mRNA levels of HIF-1alpha compared to luminal types and silencing of HIF-1alpha results in decreased expression of hypoxia-induced genes
21671140 Immunohistochemical analysis of early-stage breast cancer: eNOS was found in 159 cases, VEGF in 131 cases, HIF-1alpha in 139 cases, VEGFR2 in 185 cases and inducible NOS in 22 cases.
21666710 new function of CEBP-delta in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells
21651746 This is the first report that examined HIF1A polymorphisms in chronic obstructive pulmonary disease and demonstrated a possible role of HIF-1alpha in COPD, as well as GSTP1 and EPHX1.
21649463 Wnt/beta-catenin signaling pathway might be a necessary endogenous signal that directly controlled the Epithelial-Mesenchymal transition occurrence induced by HIF-1alpha.
21647551 HIF-1alpha expression in primary hepatocellular carcinoma was associated with External beam radiotherapy response of abdominal metastatic lymph nodes and poor prognosis.
21640852 HIF-1 pathway inhibition may be mediated by the inhibition of mitogen-activated protein kinases.
21637285 elevated expression of the hypoxia-inducible transcription factor-1 (HIF-1) and HIF-2 is a key feature of many human cancers and has been shown to promote cellular processes, which facilitate tumor progression
21633368 There is a role for HIF-1alpha in cutaneous angiogenesis, skin tumorigenesis, and several skin disorders.
21629773 Over-expression of miR-22 inhibits HIF-1alpha expression, repressing vascular endothelial growth factor (VEGF) production during hypoxia.
21625218 results establish the interplay between JMY and HIF-1alpha as a new mechanism that controls cell motility under hypoxic stress
21620138 Interaction of PKM2 with prolyl hydroxylase 3 (PHD3) enhances PKM2 binding to HIF-1alpha and PKM2 coactivator function; PKM2 participates in a positive feedback loop that promotes HIF-1 transactivation and reprograms glucose metabolism in cancer cells.
21617216 High Coexpression of HIF1alpha and NOTCH1 is associated with Non-Small-Cell Lung Carcinoma.
21613675 an increase in the NCX1 mRNA due to the apoptosis induction is not regulated by HIF-1alpha
21612401 hypoxia-induced expression of AQP1 requires transcriptional activation, and the HIF-1 binding site of the 5'-promoter is necessary for transcriptional activation
21610325 Results confirm that HIF-2alpha is tumor suppressive, and suggest that HIF-1alpha may also be tumor suppressive.
21602890 these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.
21586227 HIF1-alpha gene silencing can regulate the growth cycles of HepG2 cells, promote cell apoptosis and inhibit cell proliferation.
21576240 Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells.
21574962 hypoxia decreases MSC cell migration through an HIF-1alpha and RhoA-mediated pathway
21571835 these results have provided new mechanistic insights into the differential regulation of HIF-1alpha and HIF-2alpha by the hypoxic tumor microenvironment.
21559462 OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization
21559457 the TSC/mTOR/HIF axis is activated by the KSHV vGPCR in Kaposi's sarcoma, which amplifies the angiogenic signal
21557766 Underexpressed miR-199b, which may be via the upregulation of Hif1alpha in hepatocellular carcinoma, is inversely correlated with survival and directly correlated with the malignant status of HCC patients.
21555452 hypoxia-induced miR-210 represses GPD1L, contributing to suppression of prolyl hydroxylases activity, and increases of HIF-1alpha protein levels.
21547579 The impact of VHL genetic alterations on the expression of several pVHL protein targets in paired normal and tumor tissue, was evaluated.
21544845 Epidermal growth factor receptor-mediated signaling pathways are important in regulating cigarette smoke-induced Hypoxia inducible factor-1 activation and MUC5AC expression.
21540178 RTEF-1 as a regulator of HIF-1alpha transcription
21538273 HIF-1alpha and microlymphatic vessel density play important roles in the development of rectal cancer,which may promote lymphatic micrometastasis.
21538185 HIF-1alpha expression in cardiosphere-derived cells (CDC) blunted the beneficial functional effects of CDC transplantation, suggesting that paracrine factor balance may play an important role in cardiac regeneration.
21533547 HIF-1alpha mediates hypoxia-induced up-regulation of RANKL expression
21519196 depletion of hypoxia inducible factor 1 alpha subunit suppressed the tumorigenicity of esophageal carcinoma cells in vivo
21517900 HIF-1alpha expression is increased in patients with asthma and rhinitis after allergen challenge.
21517260 Expression of DLL4, VEGF and HIF-1alpha was very strong in gliomas.
21515475 The expression of HIF-1alpha mRNA is closely related to the staging of colorectal cancer.
21514280 hypoxia upregulates RANK and RANKL expression and increases RANKL-induced cell migration via the PI3K/Akt-HIF-1alpha pathway.
21512126 mutations on ARNT PAS-B modulate coactivator selectivity and target gene induction by HIF in vivo, demonstrating a bifunctional role for transcriptional regulation by PAS domains within bHLH-PAS transcription factors
21483406 ZNF217 is overexpressed in GBMs and contributes to the maintenance of GSCs, which is regulated by HIFs released by the hypoxic environment of the tumor
21481907 The cellular protein hypoxia-inducible factor 1 alpha (HIF-1alpha) was induced after infection of human fibroblasts with human cytomegalovirus (HCMV).
21473672 honokiol can exert its anticancer activity as a HIF-1alpha inhibitor by reducing HIF-1alpha protein level and suppressing the hypoxia-related signaling pathway
21460102 hypoxia-induced MAT2A expression is HIF-1alpha dependent
21458421 these observations show that hypoxia-stabilized HIF-1a induces the repression of the ESR1 gene, which may facilitate hormone insensitivity in the tumor microenvironment.
21454812 Hypoxia upregulates low-density lipoprotein receptor-related protein-1 expression and aggregated low-density lipoprotein-derived intracellular cholesterol esters accumulation in human vascular smooth muscle cells through HIF-1alpha induction.
21448921 findings show that monocyte-derived dendritic cells, exposed to hypoxia, expressed high levels of the hypoxia-inducible factor (HIF)-1alpha, associated with upregulation of BNIP3 and BAX expression
21448281 The role of DDX3 as a hypoxia-inducible gene that exhibits enhanced expression through the interaction of hypoxia inducible factor-1 with hypoxia inducible factor-1 responsive elements in its promoter region, is reported.
21438910 Coexpression of high levels of HIF-1alpha and GLUT-1 is significantly correlated with prognosis in oral squamous cell carcinoma patients.
21437769 Inhibition of HIF-1 activation by using HIF-1alpha-targeted siRNA clearly acts synergistically with radiotherapy and increase radiosensitivity of hypoxic cells in vitro.
21435239 results show that ER-beta suppresses HIF-1alpha-mediated transcription via aryl hydrocarbon receptor nuclear translocator (ARNT)downregulation, which may account for the tumour suppressive function of ER-beta
21435097 functional polymorphisms in the HIF-1alpha gene may have an important impact on lung carcinogenesis, especially in adenocarcinomas, possibly by increasing genomic instability
21426805 HIF-1alpha was expressed in all tumor cells lines studied, with the highest expression in the MDA-MB-231 cell line.
21426663 The expression of HIF-1alpha was positively correlated with the size of the cancer.
21421125 Prolyl hydroxylases (PHD3) regulate the transcriptional activity of HIF-1alpha. This could be potentially inhibited by polynitrogen compounds.
21420913 As HIF-1 is linked with an efficient immune response and pulmonary complications in cystic fibrosis, this difference in HIF-1alpha protein levels could have an impact in the CF pathology and the persistence of P. aeruginosa infection.
21415706 lowered expression is associated with decreased overall survival in gallbladder cancer patients
21412054 HIF-1alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs.
21401309 Results showed that exposure to Nano-Ni caused HIF-1alpha accumulation in the nucleus of U937 cells.
21397863 SIRT3 expression is reduced in human breast cancers, and its loss correlates with the upregulation of HIF1alpha target genes.
21392092 Melatonin inhibited the stability of HIF-1alpha in a time- and concentration- dependent manners. Also, melatonin decreased SPHK1 activity in PC-3 cells during hypoxia.
21386837 Suppressing HIF-1alpha expression in clear cell renal cell carcinoma cell line prevented FIH-1 knockdown from increasing apoptosis
21378341 There was no association between the genotype of HIF1A SNP and clinicopathological parameters of colorectal cancer. There is an association between the HIF1A 1772C/T SNP and developing colorectal cancer, especially in individuals older than 60 years.
21362301 Data conclude that HIF-1alpha and HIF-2alpha may differentially regulate the major angiogenic factors in different stages of the tumor process in NSCLC.
21360641 Dual-luciferase reporter assay showed that iron regulatory protein 1 (IRP)1 was directly downregulated by hypoxia-inducible factor 1/hypoxia response element system.
21357506 Phosphatidylinositol 3'-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1(alpha) and vascular endothelial growth factor expression in hypoxia.
21350119 These results identify adrenomedullin as an endogenously generated vascular mediator that functions as a mucosal protective factor through fine tuning of HIF activity.
21345792 Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
21344271 The T-allele of HIF1A P582S was associated with greater gains following endurance training in young women.
21343371 Data supports activation of a central IL6-STAT3-HIF1A pathway in OCCA.
21338575 In MCF-7 cells, the activation of HIF1 on the novel hypoxia response element contributes to the breast cancer-specific hypoxic induction of GAPDH gene expression and absolutely depends on the presence of Sp1 on the GC-box.
21330825 In conclusion, although HIF-1alpha genetic polymorphisms appear to have little association with cervical cancer risk and prognosis, individual variance of HIF-1alpha gene may be associated with cervical cancer invasiveness.
21330458 Data show that VEGF-C and HIF1a mRNA were significantly upregulated in oxaliplatin-related SOS.
21329466 This study suggested that CT genotype and the T allele of HIF-1alpha C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China.
21320746 Stem cell factor/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1alpha under normoxic condition
21303984 HIF-1alpha induction of genetic alteration is the underlying cause of tumor progression, especially by the hypoxic microenvironment.
21278237 Data highlight NRF2 as a candidate molecular target to control tumor angiogenesis by imposing a blockade to HIF-1alpha signaling.
21269972 The expressions of HIF-1alpha and VEGF in synovial tissue are significantly higher in osteoarthritis cases than in cases of acute traumatic arthritis.
21266827 In the HER2 overexpression type and triple-negative breast carcer, tumor cell proliferation and survival in the hypoxic tumor environment could possibly be due to disinhibition of the mTOR pathway and HIF-1alpha stabilization by downregulation of REDD1.
21266576 HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling
21264265 ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene
21258402 HSF2 and HSF4 regulate transcription of HIF-1alpha and that a critical balance between these HSFs is required to maintain HIF-alpha expression in a repressed state.
21257819 These findings identify snail as a HIF target gene.
21256111 CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway.
21254648 HIF-1alpha regulates the expression and function of its downstream target genes, COX-2 and VEGF, which play a critical role in the angiogenesis of laryngeal carcinoma
21251377 Serum levels of HIF-1alpha, ET-1 and iNOS increase in neonates with hypoxia-induced pulmonary hypertension (HPH), resulting in an imbalance of ET-1 and NO. This may be of importance in the pathogenesis of neonatal HPH.
21249310 Celastrol regulates HIF-1alpha at multiple levels that may together or individually contribute to its antitumor activity against hypoxia-induced angiogenesis and metastasis.
21248371 These findings identify a novel circuitry between HIF-1alpha and p53, and provide a paradigm for HIPK2 dictating cell response to antitumor therapies.
21242594 Hypoxia-inducible factors (HIFs)have been identified as key mediators of adaptation to hypoxia.
21239473 these findings provide compelling evidence that LOX and HIF-1 act in synergy to foster tumor formation
21227008 This study examined levels of hypoxia inducible factor-1alpha (HIF-1alpha) protein in 40 laryngeal squamous cell carcinoma specimens using immunohistochemistry.
21224490 The CRE-like site located near the SBE may contribute to the formation of a stable complex of STAT3, HIF-1alpha, and p300/CBP, which leads to maximum transcription of the Hp gene.
21220510 Microtubule integrity and dynamics are intricately involved in orchestrating HIF-1alpha translation.
21213129 Elevated expression of HIF-1alpha is associated with early-stage cervical cancers.
21209911 1, 9 PA may enhance the response of cancer cells to cetuximab through a complementary effect on the downregulation of HIF-1alpha
21207956 HIF1-mediated ALAS2 upregulation promotes erythropoiesis to satisfy the needs of an organism under hypoxic conditions.
21193393 NEDD8 is an ancillary player to regulate the stability of HIF-1alpha
21193390 HIF-1 signaling underlies the increase of FBLN5 expression elicited by hypoxia in endothelial cells suggesting that FBLN5 induction could be involved in the adaptive survival response of endothelial cells to hypoxia
21187066 NF-kappaB-mediated inflammatory signaling is able to block HIF-1alpha transactivation at hypoxia response elements-encoding genes by direct competition for p300 binding at the promoter.
21185840 NHE1 might participate in HIF-1-induced angiogenesis due, at least in part, to the alteration of calpain activity.
21179202 Zinc downregulates HIF-1alpha and inhibits its activity in tumor cells in vitro and in vivo
21176961 HIF-1alpha is an outcome marker for normal karyotype acute myeloid leukemia .
21167768 overexpression of HIF-1alpha, TWIST2 or SNIP1 correlated with poor disease-free survival in patients with tongue squamous cell carcinoma
21163055 Silencing HIF1a increases the apoptosis ratio in human gastric cancer cell in a high pressure environment.
21162194 The protein expression levels of VEGF and HIF-1alpha were decreased in HepG2 cells subjected to hypoxia acclimatization compared to cells treated with acute hypoxia.
21156006 telomerase expression and activity are induced through both direct phosphorylation of hTERT by phospho-AKT as well as PI3K-dependent transcriptional regulation involving Hif1-alpha as a key transcription factor
21143841 HIF-1alpha and MRP1 may play a role in the multidrug resistance of chordoma to chemotherapy.
21124777 Data shows that increased association of Hsp40/70 with HIF-1alpha led to recruitment of CHIP, which promoted polyubiquitination and degradation of HIF-1alpha.
21109953 overexpression of Tbeta4 is strongly associated with HIF-1alpha and HIF-2alpha expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer
21095582 Hypoxia results in ataxia telangiectasia mutated (ATM)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (HIF-1alpha) on serine(696) and mediates downregulation of mTORC1 signaling.
21092233 HIF-1alpha has an important role in up-regulating MICA expression, inducing IFNgamma secretion and NK cell cytotoxicity during hypoxia/reoxygenation.
21090098 HIF-1alpha and CA IX were over expressed in nasal polyps.
21085474 Data show that the inhibitory effect of TPZ on HIF-1alpha protein synthesis is dependent on the phosphorylation of translation initiation factor 2alpha (eIF2alpha).
21075472 high expression in squamous cell lung carcinoma is associated with a poor survival
21073737 Data reveal that HIF-1alpha and HIF-2alpha work together to modulate cancer metabolism and regulate genes signature overlapping with oncogenic KRAS.
21073615 Regression analysis showed that HIF 1alpha was not an independent prognostic factor for survival in SCC of the esophagus in our study on European population.
21069452 Report nuclear co-localization and functional interaction of COX-2 and HIF-1alpha characterize bone metastasis of human breast carcinoma.
21061787 Concomitant expression of HER2 (protein tyrosine kinase-type cell surface receptor HER2 ) and HIF-1alpha (hypoxia inducible factor 1 alpha) is a predictor of poor prognosis in uterine cervical carcinoma treated with concurrent chemoradiotherapy
21059928 HIF-1 plays a role in Hyperthermia-induced tumor reoxygenation by transactivating its downstream targets.
21059659 XOR promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, PPARgamma SUMOylation, and HIF-1alpha
21057546 TGF-beta1 activates VEGF expression via multiple routes including Smad3, HIF-2alpha and HuR signaling
21050481 HIF-1alpha is inhibited by siRNA or chetomin in human malignant glioma cells
21042786 Of specimens with VHL alterations 95.6% tested positive for EPO. EPO was identified in 96.2 and 94.2% of HIF-1alpha and HIF-2alpha positive specimens, respectively, compared to 72.4 and 53.8% for HIF-1alpha and HIF-2alpha negative groups (p<0.01).
21042761 ROS mediated HIF-1alpha activation is a crucial mechanism involved in hypoxia-induced differential radioresistant in U87 gliomas.
21042279 Our results provide novel and highly unexpected insights into the complexity of HIF-1alpha regulation in cancer cells and implicate that tumor-associated CpG demethylation augments HIF-1alpha-mediated effects on malignant cell growth.
21037926 Review: Define the regulatory axis consisting of Siah2 and HIF-1alpha/FoxA2 cooperation and suggest novel therapeutic modalities to treat these most aggressive forms of prostate cancer.
20978319 HIF-1alpha, HIF-2alpha and CAIX were up-regulated in 88.2% (15/17), 100% (17/17) and 88.2% (15/17) of CCRCC tumors respectively and their expression is independent of VHL status.
20977930 For the first time, clinical and functional abnormalities in the HIF-1 pathway are demonstrated during hypoxia in monocytes from sporadic amyotrophic lateral sclerosis patients.
20977846 Ulip1 was downregulated and HIF1a was upregulated in hypoxic neuroblastoma cells.
20972335 These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis, and regulate HIF-1alpha isoforms..
20970309 Elevated HIF-1alpha gene expression was associated with poor overall survivalin rectal cancer
20965423 Studies indicate that HIF2alpha is selectively expressed in the CD133+ subpopulation of glioblastoma cells, whereas HIF1alpha expression is widespread among both tumorigenic and nontumorigenic cells.
20964835 Analysis of renal carcinoma cells for expression of HIF-1a and HIF-2a confirmed high levels of hypoxia inducible factor in cells lacking functional von Hippel-Lindau (VHL) tumour suppressor.
20962622 Nuclear expression of HIF1A by the tumor cells is associated with deep myometrial invasion in endometrioid carcinoma.
20953377 HIF-1, CXCR4, and VEGF high expression levels in colon cancer were correlated positively with TNM stage, lymph node involvement, and distant metastasis.
20952681 ET-1-mediated MIP-1beta gene expression is regulated via hypoxia-response elements, AP-1, and NF-kappaB cis-binding elements in its promoter and negatively regulated by microRNA-195, which targets the 3' untranslated region of MIP-1beta RNA
20952631 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20943999 molecular studies led to the discovery of a previously unappreciated HIF-1 binding site in the FADD promoter, which controls repression of FADD during hypoxia.
20938207 Hypoxia facilitates HIF-1alpha up-regulation in Human aortic smooth muscle cell in addition to driving enhanced secretion of MMP-2 and MMP-9
20937289 CBP/p300, which interacts with the transactivation domains of HIF-1alpha, is important for HIF-1alpha-induced transcription of angiogenic genes.
20932347 The potent induction of HIF-1alpha protein involved in its cytotoxicity, together with the suppression of HIF-1 transcriptional activity, indicates the great therapeutic potential of triptolide as an anticancer drug.
20932296 Tendon retraction in full-thickness medium-sized rotator cuff tears is characterized by neovascularity and increased expression of hypoxia inducible factor 1alpha and vascular endothelial growth factor.
20931543 HIF1A gene is under hypoxic selection induced by high altitude in the three groups.
20931543 Observational study of genotype prevalence. (HuGE Navigator)
20926496 Conclude that functional polymorphisms in the HIF1A gene do not contribute to susceptibility to peripheral arterial disease.
20926496 Observational study of gene-disease association. (HuGE Navigator)
20924210 The inhibition of HIF-1alpha inhibits the invasion, tube formation, and cell growth in HUVECs and HCC cells.
20924188 HIF-1alpha(+) cells in pancreatic ductal adenocarcinomas and nonmalignant pancreatic tumors differ not only in their amounts but also in their relation to intratumoral blood vessels.
20889502 Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
20888838 results show that CHMP4A significantly enhances the stability and transcriptional activity of HIF-1alpha both under normoxic and hypoxic conditions
20888814 Results demonstrated that HIF1 promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia.
20885442 miR-210 regulates mitochondrial function by targeting key electron transport chain component genes with important consequences on cell metabolism, survival and modulation of HIF-1 activity.
20876310 HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment.
20871160 iNOS and HIF-1alpha are highly expressed in psoriasis and might play an important role in the genesis and development of psoriasis.
20864819 Hypoxia inducible factor 1 alpha subunit activation in different cell types can either promote or repress tumorigenesis.
20857420 Thrombin upregulates Twist via HIF-1alpha to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis.
20848794 T/C and T/T genotypes of HIF-1alpha C1772T are genetic susceptibility factors for cervical cancer in the Han population in Sichuan province of China.
20848794 Observational study of gene-disease association. (HuGE Navigator)
20845004 Overexpression of HIF1A is associated with gastric adenocarcinoma.
20844082 a novel link between APC and hypoxia and show that APC and HIF-1alpha antagonize each other
20838824 A pathogenetic role in mantle cell lymphoma; HIF-1alpha appears to be associated with more aggressive disease.
20832699 Observational study of gene-disease association. (HuGE Navigator)
20827750 Interaction of hypoxia-inducible factor-1alpha and NOTCH1 regulates medulloblastoma precursor proliferation and fate.
20813154 aberrant activation of HIF-1 in malignant lymphoma cells was mediated, at least in part, by NF-kappaB activity.
20811474 Hypoxia is associated to angiogenesis in solid tumors and hypoxia-inducible factor (HIF)-1alpha is a critical trigger and regulator of the angiogenic switch.
20807755 The HIF-1alpha showed promoting roles in tumor angiogenesis and growth, and therapeutic outcome may benefit from combined targeting of HIF-1alpha
20800603 Observational study of gene-disease association. (HuGE Navigator)
20729179 Culture of primary AML cells under low oxygen tension induces HIF-1alpha expression and increases the release of several cytokines, including proangiogenic mediators, compared to culture at ambient 21% O(2)
20727020 DNA methylation analysis of the HIF-1alpha prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas
20724477 These results suggest that carbon monoxode stimulates VEGF production by increasing HIF-1alpha protein level via two distinct mechanisms, translational stimulation and protein stabilization of HIF-1alpha.
20723413 RNA interference of HIF-1alpha prevents hypoxia-induced increase in vascular endothelial cell permeability.
20716529 indispensable role of HIF1alpha in maintaining the thermogenic functions of BAT, possibly through promoting angiogenesis and mitochondrial biogenesis in this tissue.
20713124 Results suggested that the suppression of HIF-1alpha accumulation by IDPm knockdown in PC3 cells was due to an inhibition of HIF-1alpha transcription.
20711226 Evidence accumulated during the past 7 years suggests a critical role for HIF-1-alpha in mediating cardioprotection.
20706634 HIF-1alpha as a potent regulator of p53 and NF-kappaB activity under conditions of genotoxic stress
20691219 Data in colon cancer tissue microarray showed that thymosin beta4 and HIF-1alpha co-localized in these biopsies.
20678440 HIF-1alpha expression is associated with occurrence and development of hepatocellular carcinoma.
20675386 Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.
20669661 AQP5, HIF-1alpha, VEGF are all involved in edema formation in nasal polyps. HIF-1alpha and VEGF can induce new blood vessels and increase vasopermeability in nasal polyps.
20668552 Study identified the stabilization of HIF-1alpha protein as a mechanism through which bcl-2 induces the activation of HIF-1 in hypoxic tumour cells involving the beta isoform of molecular chaperone HSP90.
20667978 Results demonstrate that HIF is sufficient to enhance osteoclast-mediated bone resorption and that ANGPTL4 can compensate for HIF-1alpha deficiency with respect to stimulation of osteoclast activity and augments osteoblast proliferation and differentiation.
20663134 Cytoplasmic stabilization of HIF1alpha in neuroendocrine differentiated cells is associated with benign and malignant prostate tissue and is due to presence of an HIF1alpha isoform, HIF1alpha1.2.
20661931 increased HIF-1alpha levels mediated up-regulation of Bcl-xL play a prominent role in evasion of apoptosis and tumor progression
20661259 TLR4-mediated SphK1 activation was found to be critical for the redox-dependent activation of HIF-1alpha and ASK1, and the prevention of lipopolysaccharide-induced activation of caspase 3 and the expression interleukin-6.
20661221 Studies define an important role of PIASy in hypoxia signaling through promoting HIF1alpha SUMOylation.
20659427 This study focuses on the influence of HIF-1alpha on regulation of TRAIL apoptotic activity in hypoxic tumor cells.
20656543 These findings may suggest a correlation between the HIF-1alpha C1772T and G1790A polymorphisms and the growth of oral squamous cell carcinoma, and the decrease of its recurrence frequency.
20656543 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20651983 Differences in the basal level of HIF-1alpha expression in different prostate cancer cell lines underlie their differential response to TLR3 activation, suggesting a correlation between hypoxic gene expression and tumor responsiveness to TLR agonists.
20651398 HIF1A1 C1772T and G1790A polymorphisms are not involved in the progression or metastasis of colorectal cancer.
20651398 Observational study of gene-disease association. (HuGE Navigator)
20648588 Genetic polymorphism at G1790A of HIF-1alpha is an important factor for determining the susceptibility to hepatocellular carcinoma
20648588 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20644645 Activation of HIF-1 is a general phenomenon in infections with human pathogenic bacteria, viruses, fungi and protozoa
20644561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20635169 HIF-1alpha gene polymorphisms investigated in this study were not found to be an independent prognostic marker for Korean patients with surgically resected colorectal cancer
20635169 Observational study of gene-disease association. (HuGE Navigator)
20634891 Observational study of gene-disease association. (HuGE Navigator)
20631454 is possible that upregulation of HIF-1/VEGF is involved in the enhancement of MMP-9 expression under hypoxic conditions.
20631377 SDF1 transcriptional up-regulation after ionizing radiation is mediated by both HIF1A dependent and -independent mechanisms in endothelial cells.
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627616 REVIEW: in gynecological cancers, HIF-1A is emerging as an important factor in carcinogenesis, and overexpression of HIF-1A and its target genes CA9 and SLC2A1 seems associated with shorter progression free- and overall survival
20624928 HIG2 is a direct and specific target of HIF-1
20624301 These results show for the first time that mRNA expression of a HIF-1alphaTAG splice variant reflects a stage of breast cancer progression and is associated with a worse prognosis.
20620956 crosstalk between oxygen- and redox-responsive signal transducers occurs through the SIRT1-HIF-1alpha interaction.
20602615 Observational study of gene-disease association. (HuGE Navigator)
20599538 p70S6K1 is required for tumor growth and angiogenesis through HIF-1alpha and VEGF expression, providing a molecular mechanism of human ovarian cancer mediated by p70S6K1 signaling.
20596845 There is no consistent relationship between LMP1 and either HIF-1alpha expression or degree of microvasculature in nasopharyngeal carcinoma
20596750 High HIF1alpha expression was associated with strocytic tumors associated with necrosis.
20581113 Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.
20574527 the underlying mechanism by which ET-1, through the regulation of PHD2, controls HIF-1alpha stability and thereby regulates angiogenesis and melanoma cell invasion
20572162 Single nucleotide polymorphisms in the HIF1A gene and colorectal neoplasms are reported.
20572162 Observational study of gene-disease association. (HuGE Navigator)
20569445 Intratumoral hypoxia in breast cancer is marked by coordinated expression of such markers as HIF-1alpha, Glut-1, leptin and ObR. The relationships among these proteins can be altered by preoperative chemotherapy.
20562128 Hypoxia inducible factor-1alpha has a role in human emphysema lung tissue
20561442 Bortezomib may down-regulate the expression of VEGF in endothelial cells through regulating the activity of HIF-1alpha and the expression of Annexin A2.
20559438 Both HIF-1alpha and HIF-2alpha are activated in close correlation with retinal hypoxia but have contrasting cell specificities, consistent with differential roles in retinal ischaemia
20559021 present work suggested that HIF-1alpha and HIF-2alpha were involved in metastasis and invasion of gastric cancer cells under hypoxia, with the involvement of JNK signal pathway
20556833 The expression of TLR4 and HIF-1alpha had a significant impact on survival of patients with pancreatic adenocarcinoma.
20556580 Insulin dose-dependently increased the HIF-1alpha protein expression, and YC-1 could dose-dependently block this effect in PANC-1 cells.
20544685 HIF-1alpha is an independent prognostic marker in oral squamous cell carcinoma.
20540786 Observational study of gene-disease association. (HuGE Navigator)
20538960 Observational study of gene-disease association. (HuGE Navigator)
20526721 The expression of HIF-1alpha and GLUT1 proteins was increased after CoCl(2)-induced hypoxia in all breast cancer cell lines tested
20526373 Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin.
20525878 HIF1A increases galectin-1 expression in both messenger RNA and protein levels in colorectal cancer.
20515450 knock down of HIF-1alpha in human and murine glioma cells impairs their migration in vitro and their invasion in vivo.
20514457 Development of a controlled and comparative HIF-1alpha immunoassay.
20514449 Hypoxia-inducible factor-1alpha induces down-regulation of CDX2 in colon carcinoma cells and Snail may be involved in this regulation process.
20513003 HIF-1alpha-knockdown increases HIF-2alpha expression and shifts the balance of Bcl-2 family members toward cell survival.
20509143 The aggressive stem cell-like phenotype of breast cancer cells is induced by inflammatory cytokine TNF-alpha activation SLUG via NFkB/HIF1a, which is further enhanced by the loss of p53 function.
20501419 A positive correlation was found between the expressions of HIF-1alpha and MMP-2 in degenerative intervertebral discs.
20501388 Low-dose fractioned irradiation can lower MDR1 and HIF1alpha expressions in esophageal cancer cells.
20498255 Propose that HIF-1 is centrally involved in carotid artery remodelling in response to arterial injury and that localized inhibition of HIF-1 may be a novel therapeutic strategy to prevent carotid stenosis.
20496369 Both HIF-1 and HIF-2 serve as negative regulators of ANK expression in the disc. We
20478051 the expression of miR-101 is also modulated at different physiological conditions, such as androgen stimulation and HIF-1alpha/HIF-1beta induction.
20473281 Hypoxia-inducible factor-1alpha is expressed in papillary thyroid carcinomas and is regulated not only by hypoxia but also by BRAF(V600E)-mediated signaling pathway.
20470445 tasquinimod-induced up-regulation of TSP1 is part of a mechanism involving down-regulation of HIF1alpha and VEGF, which in turn leads to reduced angiogenesis
20459575 The constitutive activation of the transcription factor HIF-1alpha in high-grade chondrosarcoma could play a central role in the regulation of cell metabolism and vascularization in these tumours.
20453713 Results show increased mucosal HIF-1alpha expression in celiac disease (CD) and suggest the contribution of this signaling pathway in the pathomechanism of CD.
20453000 Observational study of gene-disease association. (HuGE Navigator)
20429620 Overexpression of HIF1-alpha is associated with colon cancer.
20427666 IGF-1 increases expression of HIF-1 through activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of the rapamycin (mTOR) signaling pathway and leads to increased VEGF secretion, which enhances excitatory synaptic transmission
20427574 These data suggest an important role of the signaling axis between NOX4 and HIF-1alpha in various cardiovascular disorders under hypoxic and also nonhypoxic conditions.
20427344 data suggest that HIF-1alpha-deficient Mcapital EF, Cyrillics develop a more prominent tumor-associated macrophages (TAMs) marker profile accompanied by reduced cytotoxicity, whereas HIF-1 seems indispensable for the angiogenesis-promoting properties of TAMs
20427288 Net and HIF1alpha are components of distinct signaling pathways that are intricately linked
20416395 Hypoxia upregulated transcription from all three alternative HIF-3alpha promoters. siRNA experiments showed that this induction is mediated specifically by HIF-1 and not by HIF-2.
20414936 Subsets of patients with colon adenocarcinoma demonstrate specific protein/gene alterations regarding EGFR/VEGF/HIF1a molecules.
20412701 results do not confirm an implication of HIF-1alpha gene polymorphisms in the susceptibility to and clinical expression of giant cell arteritis
20407014 Insights and validation are provided for interaction of septin 9 transcript variant 1 as a potential target for antitumor therapy via interruption of the HIF-1 pathway.
20403915 Observational study of gene-disease association. (HuGE Navigator)
20398289 An acute dose of albendazole in profoundly suppresses both HIF-1alpha and VEGF within ovarian tumors.
20398057 HIF-1alpha and VEGF did not appear to be related to clinical outcomes in stage III colorectal cancer patients.
20393480 the pro-apoptotic mechanisms orchestrated by p38(MAPK) in human keratinocytes in response to ultraviolet rays B involve an HIF-1/Noxa axis
20392254 Manipulation of HIF-1 does not influence angiogenesis of the skull bones, where earlier activation of HIF-1 in the condensing mesenchyme upregulates osterix during cranial bone formation.
20392253 Hif-1alpha is required for chondrogenesis in vivo by controlling a complex homeostatic response that allows chondrocytes to survive and differentiate in an hypoxic environment.
20389299 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20388348 HPSE, HIF-1alpha and VEGF play a role in tumor angiogenesis and promote malignant progress of retinoblastoma.
20383692 Hypoxia-inducible factor 1 alpha-deficient hepatocellular carcinoma cells displayed significantly reduced anchorage-independent growth and enhanced sensitivity toward etoposide, while basic cellular proliferation was unaffected.
20380593 Nitric oxide (NO) induces HIF-1alpha stabilization in human endothelial cells from umbilical cords under normoxic conditions. Loading of the cells with vitamin C counteracted NO-induced HIF-1alpha accumulation.
20374513 expression of HIF-1alpha was higher in oral lichen planus than in controls
20368331 Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation
20363910 HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers
20348876 The data indicate that blocking hypoxia-inducible pathways by antisense HIF-1alpha can circumvent hypoxia-induced drug resistance and thereby augment the efficacy of anti-angiogenic therapies.
20347817 Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury.
20347035 Nrf2-dependent Trx1 induction turned out to enhance HIF-1 alpha signaling in intermittent hypoxia.
20346360 Observational study of gene-disease association. (HuGE Navigator)
20308562 the hypoxia component of ischemia may limit wound re-epithelialization by stabilizing HIF-1alpha, which induces miR-210 expression, resulting in the down-regulation of the cell-cycle regulatory protein E2F3
20307196 The binding between p16 and HIF-1a protein may alter HIF-1a's ability to transactivate VEGF expression in breast tumor cells.
20303950 12-LOX increases the protein level, mRNA, and functional activity of HIF-1alpha in prostate cancer cells under hypoxic conditions, one of the mechanisms by which it upregulates VEGF secretion and activity
20300531 Knockdown of PIASy by small interfering RNA leads to reduction of VHL oligomerization and increases HIF1alpha degradation
20299614 We found preliminary evidence that the HIF1A Pro582Ser polymorphism and a common haplotype of the HIF1A gene may be associated with EEA status in Caucasian men.
20299614 Observational study of gene-disease association. (HuGE Navigator)
20237132 CYR61 and NOV are regulated by HIF-1alpha and TGF-beta3 in the trophoblast cell line JEG3, and their enhanced secretion could be implicated in appropriate placental invasion.
20232316 VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b-dependent manner.
20232298 Hypoxia enhances BMP-2 expression in osteoblasts by an HIF-1alpha-dependent mechanism involving the activation of ILK/Akt and mTOR pathways.
20228066 data support the idea that modulation of carcinogen metabolism may be an important mechanism for the observed HIF-1-mediated genetic instability, suggesting a potential role in cancer development
20217131 Expression of HIF-1alpha and MDR1/P-gp in colon carcinoma and HIF-1alpha expression may be associated with the gene MDR1 (P-gp) and interactively.
20206160 HIF-1 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells
20204822 Uterine leiomyomas are severely and uniformly hypoxic, but do not induce HIF-1alpha, HIF-2alpha, glucose transporter (GLUT)-1 or carbonic anhydrase (CA) IX.
20198320 Xenografts derived from mixed populations of HIF-1alpha-positive and HIF-1alpha-negative glioblastoma cells were more aggressive than those obtained by grafting each cell population separately.
20197612 HIF-1alpha in coordination with vWF may play an important role in the pathogenesis of pre-eclampsia.
20194889 Mutation of lysine 532 of HIF-1alpha in B16F10-mARD1A(225) cells prevented HIF-1alpha degradation and inhibited the antimetastatic effect of mARD1A(225) (P < .001).
20194722 Hypoxia augmented binding of HIF-1alpha to hypoxia-response elements in 5-lipoxygenase activating protein promoter
20184881 Tumor cells deprived of glutamine showed HIF-1alpha accumulation in the absence of glucose, proposing that enhanced glutaminolysis observed in many tumors enables these cells to compensate reduced oxoglutarate production in the absence of glucose.
20174965 Data suggest that betulinic acid may have anti-angiogenic potential by inhibition of prolidase, HIF-1alpha and VEGF expressions, and inhibition of collagen biosynthesis.
20169663 Sensitivity of ovarian cancer cells to p38 blockade seems to rely on a shift from HIF1alpha- to FoxO3A-dependent transcription, which is promoted by the activation of the adenosine monophosphate-activated protein kinase pathway.
20166137 Our findings suggest that ELL and HIF-1alpha are binding partners and can modulate the functions of each other in hypoxia.
20165885 These are the first data that demonstrate an influence of betacellulin upon mesenchymal stem cells and the first to implicate HIF-alpha in betacellulin-mediated proliferation.
20164027 Expressions of HIF-1 show mutual correlations in primary ductal breast cancers, which suggest co-operation among the protein.
20158574 Mitochondria and HIFs are intimately connected to regulate each other resulting in appropriate responses to hypoxia.