Property Summary

NCBI Gene PubMed Count 19
PubMed Score 91.47
PubTator Score 57.76

Knowledge Summary


No data available


  Differential Expression (8)

Protein-protein Interaction (3)

Gene RIF (3)

25217524 repression of TGFbeta signaling by Notch acting through HEYL may promote initiation of breast cancer
21454491 Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
21290414 In this study, we analyzed the effects of HESR1, -2, and -3 on DAT1 expression in human neuroblastoma SH-SY5Y cells

AA Sequence


Text Mined References (21)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
25217524 2014 The Notch pathway inhibits TGF? signaling in breast cancer through HEYL-mediated crosstalk.
23222517 2012 Seventy-five genetic loci influencing the human red blood cell.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21454491 2011 Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
21290414 2011 Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.
17611704 2007 Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
16165016 2005 Hesr, a mediator of the Notch signaling, functions in heart and vessel development.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15485867 2004 Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism.
15231748 2004 Functional proteomics mapping of a human signaling pathway.
12548545 2003 HES and HERP families: multiple effectors of the Notch signaling pathway.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11095750 2000 Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.
10964718 2000 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.
10924525 2000 The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.
10860664 2000 Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.
10415358 1999 Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.