Tbio HES6 Transcription cofactor HES-6

Protein Summary

Description

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q96HZ4
• A8KAP6
• B8ZZA9
• Q53SN9
• Q8N2J2
• Q96T93
• Q9P2S3

Gene Name

• HES6

Ensembl ID

• ENST00000272937
• ENSP00000272937
• ENSG00000144485
• ENST00000409002
• ENSP00000387155
• ENST00000409160
• ENSP00000387215
• ENST00000409574
• ENSP00000387008

Symbol

• BHLHB41
• HES-6
• bHLHb41
• bHLHc23
• C-HAIRY1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
PubMedID	0.72
gene perturbation	0.68
transcription factor	0.66
transcription factor binding site profile	0.64

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Transcription Cofactor Hes-6

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Transcription Cofactor Hes-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.51   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.51   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0