| Tbio | Protein HEG homolog 1 |
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 9.6e-19 |
| lung adenocarcinoma | 2716 | 2.7e-15 |
| ovarian cancer | 8520 | 4.5e-12 |
| juvenile dermatomyositis | 1187 | 3.0e-10 |
| non-small cell lung cancer | 2890 | 4.2e-10 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.6e-07 |
| ulcerative colitis | 1819 | 5.7e-07 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.1e-06 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.6e-05 |
| lung cancer | 4740 | 1.5e-04 |
| glioblastoma | 5792 | 1.6e-04 |
| primary Sjogren syndrome | 735 | 2.0e-04 |
| group 4 medulloblastoma | 1855 | 3.3e-04 |
| interstitial cystitis | 2312 | 4.1e-04 |
| astrocytoma | 1146 | 2.3e-03 |
| cystic fibrosis | 1696 | 1.3e-02 |
| gastric carcinoma | 807 | 2.7e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 2.7e-02 |
| urothelial carcinoma | 318 | 4.0e-02 |
| ependymoma | 4679 | 4.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hemangioma | 69 | 3.419 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.100 | 2.3e-03 |
| cystic fibrosis | 1.300 | 1.3e-02 |
| ependymoma | 1.100 | 4.0e-02 |
| gastric carcinoma | 1.200 | 2.7e-02 |
| glioblastoma | 1.200 | 1.6e-04 |
| group 4 medulloblastoma | -1.500 | 3.3e-04 |
| interstitial cystitis | 1.400 | 4.1e-04 |
| intraductal papillary-mucinous adenoma (... | -1.700 | 1.1e-06 |
| intraductal papillary-mucinous carcinoma... | -1.800 | 2.6e-07 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 7.6e-05 |
| juvenile dermatomyositis | 1.226 | 3.0e-10 |
| lung adenocarcinoma | -1.900 | 2.7e-15 |
| lung cancer | -2.200 | 1.5e-04 |
| lung carcinoma | -2.300 | 9.6e-19 |
| non-small cell lung cancer | -1.096 | 4.2e-10 |
| ovarian cancer | -2.600 | 4.5e-12 |
| primary pancreatic ductal adenocarcinoma | 1.417 | 2.7e-02 |
| primary Sjogren syndrome | 1.500 | 2.0e-04 |
| ulcerative colitis | 2.100 | 5.7e-07 |
| urothelial carcinoma | 1.300 | 4.0e-02 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MASPRASRWPPPLLLLLLPLLLLPPAAPGTRDPPPSPARRALSLAPLAGAGLELQLERRPEREPPPTPPR 1 - 70 ERRGPATPGPSYRAPEPGAATQRGPSGRAPRGGSADAAWKHWPESNTEAHVENITFYQNQEDFSTVSSKE 71 - 140 GVMVQTSGKSHAASDAPENLTLLAETADARGRSGSSSRTNFTILPVGYSLEIATALTSQSGNLASESLHL 141 - 210 PSSSSEFDERIAAFQTKSGTASEMGTERAMGLSEEWTVHSQEATTSAWSPSFLPALEMGELTTPSRKRNS 211 - 280 SGPDLSWLHFYRTAASSPLLDLSSSSESTEKLNNSTGLQSSSVSQTKTMHVATVFTDGGPRTLRSLTVSL 281 - 350 GPVSKTEGFPKDSRIATTSSSVLLSPSAVESRRNSRVTGNPGDEEFIEPSTENEFGLTSLRWQNDSPTFG 351 - 420 EHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEITAHWLLTNSTTSADVTGSSASYPEGVNASVLTQFSD 421 - 490 STVQSGGSHTALGDRSYSESSSTSSSESLNSSAPRGERSIAGISYGQVRGTAIEQRTSSDHTDHTYLSST 491 - 560 FTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSSFFHAQTERSNISSYDGEYAQPSTESPVLHT 561 - 630 SNLPSYTPTINMPNTSVVLDTDAEFVSDSSSSSSSSSSSSSSGPPLPLPSVSQSHHLFSSILPSTRASVH 631 - 700 LLKSTSDASTPWSSSPSPLPVSLTTSTSAPLSVSQTTLPQSSSTPVLPRARETPVTSFQTSTMTSFMTML 701 - 770 HSSQTADLKSQSTPHQEKVITESKSPSLVSLPTESTKAVTTNSPLPPSLTESSTEQTLPATSTNLAQMSP 771 - 840 TFTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGISTERNRVIVDA 841 - 910 TTGLIPLTSVPTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAEDLAPKSATFAVQSSTQSPTTV 911 - 980 SSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGDDCSVDVNECLSNPCPSTAMCNNTQGSFICK 981 - 1050 CPVGYQLEKGICNLVRTFVTEFKLKRTFLNTTVEKHSDLQEVENEITKTLNMCFSALPSYIRSTVHASRE 1051 - 1120 SNAVVISLQTTFSLASNVTLFDLADRMQKCVNSCKSSAEVCQLLGSQRRIFRAGSLCKRKSPECDKDTSI 1121 - 1190 CTDLDGVALCQCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGL 1191 - 1260 LLILGIALIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGSTKNLLQMTDVY 1261 - 1330 YSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDYF 1331 - 1381 //
