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Tdark HEAT repeat-containing protein 3

The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 7.87
PubTator Score 2.67

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
psoriasis 6694 6.6e-62
ovarian cancer 8520 4.5e-03
osteosarcoma 7950 1.0e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Synovial sarcoma 25 5.801 2.9
Sarcoma 62 3.845 1.9

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma 1.706 1.0e-02
ovarian cancer 1.300 4.5e-03
psoriasis 1.200 6.6e-62

Synonym

Accession Q7Z4Q2 A8K1N4 Q8N525 Q8WV56 Q96CC9 Q9NWN7
Symbols SYO1

Gene

HEATR3

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Function (1)

 GO Component (1)

 GO Process (2)

 Compartment GO Term (2)

 IMPC Phenotype (1)

 MGI Phenotype (1)

 GWAS Trait (4)

 HCA RNA Cell Line (56)

See all...

Protein-protein Interaction (37)

RPL11   CCDC137   HADHA   HADHB   SGPL1   HIST1H1C   PIP5K1A   DGKE   PINX1   EXOG   SEC63   SLC27A2   RRP1B   TMED4   PLD1   CENPQ   SURF2   RPL5   TYW1B   GLE1   UXS1   DPY19L1   GOLM1   TMEM192   SEC62   HOXA5   DNAJC1   FEM1B   MAVS   GRAMD1C   MTDH   TMEM186   DHRS2   TRMT1L   ZNF346   VTI1B   LRP10  

Gene RIF (1)

AA Sequence 

MGKSRTKRFKRPQFSPTGDCQAEAAAAANGTGGEEDDGPAAELLEKLQHPSAEVRECACAGLARLVQQRP      1 - 70
ALPGLARRDAVRRLGPLLLDPSLAVRETAAGALRNLSACGGFEVCDDMVTKDIMTPLVALLKECSAGLDS     71 - 140
NEMSLQEKKDQNRNSIENIANETVNVLWNICECSSRAVSIFNKEGCLEIVLKYLSRFPTNVDLAISVAYC    141 - 210
LQTVTEDNPELLKSFSATALNMLESALLSPVSSMESLLLKTLVAGTIWNLKDIIPCKSQAEIINALLKIL    211 - 280
SEVLGMDAGEMVIQMKEAETQRLKTAAEAEEILENTNGDDLIEDDEMEGISHKRRVRRKTFVSDLLPPTD    281 - 350
KELRETIALLTAQQTALEIIVNMCCNEDPSDDEWEELSSSDESDAFMENSFSECGGQLFSPLCLSHEVHT    351 - 420
ALTNYLIPKKIFEKTAFPNSIAVDLCSRNPTWKPLIRKMNTIQCRALFCLQSLVSLLDVEHLGGAAALQT    421 - 490
LAQHLSQLLFSQPDFAKHVDFLEAISSALRALLQTMASKNISQCMTPDQLMTLCKAGIHSSNVGVRVNVV    491 - 560
SILGITGSVLAKEDGTLETLKNIGCFLLEVTTKDPSLVVAGEALDALFDVFADGKEAERASIQIKLLSAL    561 - 630
KEFQPVFKMKIRKEGRGNYSTDQLCVLDNVKMNLRRFIAYQETVEKRLTS                        631 - 680
//

Text Mined References (12)

PMID Year Title