| Tbio | Vigilin |
Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autistic Disorder | 364 | 0.0 | 0.0 |
| Chromosome 2q37 deletion syndrome | 4 | 0.0 | 0.0 |
| Neoplastic Processes | 10 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 4.4e-05 |
| ovarian cancer | 8520 | 1.2e-04 |
| lung cancer | 4740 | 2.0e-04 |
| psoriasis | 6694 | 3.7e-04 |
| adrenocortical carcinoma | 1428 | 9.9e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.6e-03 |
| astrocytoma | 1146 | 4.0e-03 |
| invasive ductal carcinoma | 2951 | 4.2e-03 |
| subependymal giant cell astrocytoma | 2287 | 4.3e-03 |
| oligodendroglioma | 2850 | 7.2e-03 |
| ependymoma | 4679 | 1.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.031 | 9.9e-04 |
| astrocytoma | 1.300 | 4.0e-03 |
| ependymoma | 1.200 | 1.3e-02 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 3.6e-03 |
| invasive ductal carcinoma | -1.113 | 4.2e-03 |
| lung cancer | 1.300 | 2.0e-04 |
| medulloblastoma, large-cell | 1.200 | 4.4e-05 |
| oligodendroglioma | 1.100 | 7.2e-03 |
| ovarian cancer | 1.900 | 1.2e-04 |
| psoriasis | 1.100 | 3.7e-04 |
| subependymal giant cell astrocytoma | -2.003 | 4.3e-03 |
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRP 1 - 70 IKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKAR 71 - 140 KDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARH 141 - 210 EVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQA 211 - 280 VARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKL 281 - 350 GQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA 351 - 420 QEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGV 421 - 490 QQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPK 491 - 560 NEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIIT 561 - 630 GKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTV 631 - 700 VIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKD 701 - 770 QDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS 771 - 840 GTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFP 841 - 910 DREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVP 911 - 980 FDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRAL 981 - 1050 RSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRI 1051 - 1120 VGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHI 1121 - 1190 LNLEEEYLADVVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPK 1191 - 1260 TLPWGPKR 1261 - 1268 //
