Tchem HASPIN Serine/threonine-protein kinase haspin

Protein Summary

Description

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

Uniprot Accession IDs

• Q8TF76
• Q5U5K3
• Q96MN1
• Q9BXS7

Gene Name

• HASPIN

Ensembl ID

• ENST00000325418
• ENSP00000325290
• ENSG00000177602

Symbol

• GSG2
• GSG2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Haspin Family / Serine/threonine-protein Kinase Haspin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.86   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.86   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0