Tbio HAS3 Hyaluronan synthase 3

Protein Summary

Description

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity). The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• O00219
• A8K5T5
• Q8WTZ0
• Q9NYP0

Gene Name

• HAS3

Ensembl ID

• ENST00000219322
• ENSP00000219322
• ENSG00000103044
• ENST00000306560
• ENSP00000304440
• ENST00000569188
• ENSP00000454731

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.92
gene perturbation	0.88
PubMedID	0.81
transcription factor binding site profile	0.76
transcription factor	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.2   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.2   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0