| Tbio | Hyaluronan synthase 3 |
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Fatty Liver | 70 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 2.7e-70 |
| psoriasis | 6694 | 2.6e-38 |
| osteosarcoma | 7950 | 1.7e-16 |
| breast carcinoma | 1638 | 1.8e-14 |
| cystic fibrosis | 1696 | 2.1e-05 |
| group 3 medulloblastoma | 4104 | 2.3e-05 |
| Atopic dermatitis | 952 | 3.1e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.2e-04 |
| pancreatic cancer | 2398 | 5.7e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.1e-03 |
| primitive neuroectodermal tumor | 3035 | 7.2e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 9.3e-03 |
| interstitial cystitis | 2312 | 3.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Attention deficit hyperactivity disorder | 278 | 0.0 | 1.1 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | 2.500 | 3.1e-04 |
| atypical teratoid / rhabdoid tumor | 2.200 | 7.1e-03 |
| Breast cancer | -3.700 | 2.7e-70 |
| breast carcinoma | -1.600 | 1.8e-14 |
| cystic fibrosis | 3.000 | 2.1e-05 |
| group 3 medulloblastoma | 3.600 | 2.3e-05 |
| interstitial cystitis | -1.900 | 3.5e-02 |
| intraductal papillary-mucinous neoplasm ... | 2.100 | 3.2e-04 |
| osteosarcoma | -5.608 | 1.7e-16 |
| pancreatic cancer | 1.200 | 5.7e-03 |
| primary pancreatic ductal adenocarcinoma | 1.473 | 9.3e-03 |
| primitive neuroectodermal tumor | 1.600 | 7.2e-03 |
| psoriasis | 2.500 | 2.6e-38 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRM 1 - 70 RRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVL 71 - 140 GGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDY 141 - 210 IQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCV 211 - 280 QCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRW 281 - 350 LNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVG 351 - 420 IIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAV 421 - 490 LLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV 491 - 553 //
