Tbio HARS2 Probable histidine--tRNA ligase, mitochondrial

Protein Summary

Description

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P49590
• B4DDY8

Gene Name

• HARS2

Ensembl ID

• ENST00000230771
• ENSP00000230771
• ENSG00000112855
• ENST00000508522
• ENSP00000423616
• ENST00000642231
• ENSP00000494569
• ENST00000645749
• ENSP00000494296

Symbol

• HARSL
• HARSR
• HO3
• HO3
• HARSL
• HARSR
• HisRS
• PRLTS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
histone modification site profile	0.91
disease perturbation	0.9
interacting protein	0.83
ligand (protein) perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Probable Histidine--trna Ligase, Mitochondrial

Protein / Ligase / Aminoacyl-trna Synthetase / Probable Histidine--trna Ligase, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Probable Histidine--trna Ligase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.72   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.72   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0