| Tchem | Hydroxyacid oxidase 1 |
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 9 |
| NCBI Gene PubMed Count | 16 |
| PubMed Score | 1057.27 |
| PubTator Score | 788.42 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Primary hyperoxaluria | 15 | 4.056 | 2.0 |
| diabetes mellitus | 1728 | 3.189 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| pancreatic ductal adenocarcinoma liver m... | -2.643 | 2.6e-02 |
CHEMBL282502
pIC50 6.22
CHEMBL18672
pIC50 6.36
CHEMBL19036
pIC50 6.40
CHEMBL276330
pIC50 6.75
CHEMBL18721
pIC50 6.80
CHEMBL428525
pIC50 6.89
CHEMBL273783
pIC50 7.05
CHEMBL282504
pIC50 7.20
CHEMBL18295
pIC50 7.22
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQR 1 - 70 VSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVT 71 - 140 KKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVA 141 - 210 KAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVE 211 - 280 AVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQ 281 - 350 NVKVIDKTLVRKNPLAVSKI 351 - 370 //
