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Tchem Hydroxyacid oxidase 1

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 9
NCBI Gene PubMed Count 16
PubMed Score 1057.27
PubTator Score 788.42

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Liver Cirrhosis, Experimental 769 0.0 0.0
Prostatic Neoplasms 495 0.0 0.0
Disease Target Count P-value
pancreatic ductal adenocarcinoma liver metastasis 1962 2.6e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
Primary hyperoxaluria 15 4.056 2.0
diabetes mellitus 1728 3.189 1.6

Expression

  Differential Expression (1)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -2.643 2.6e-02

Synonym

Accession Q9UJM8 Q14CQ0 Q9UPZ0 Q9Y3I7 HAOX1
Symbols GOX
GOX1
HAOX1

Gene

HAO1

PANTHER Protein Class (2)

PDB

2NZL   2RDT   2RDU   2RDW   2W0U  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (8)

 GO Function (8)

 GO Component (2)

 GO Process (4)

 Compartment GO Term (24)

See all...

 GWAS Trait (4)

 HCA RNA Cell Line (13)

See all...

Pathway (10)

Protein-protein Interaction (1)

KCNAB2  

Ligand (9)

Structure of CHEMBL282502

CHEMBL282502
pIC50 6.22

Structure of CHEMBL18672

CHEMBL18672
pIC50 6.36

Structure of CHEMBL19036

CHEMBL19036
pIC50 6.40

Structure of CHEMBL276330

CHEMBL276330
pIC50 6.75

Structure of CHEMBL18721

CHEMBL18721
pIC50 6.80

Structure of CHEMBL428525

CHEMBL428525
pIC50 6.89

Structure of CHEMBL273783

CHEMBL273783
pIC50 7.05

Structure of CHEMBL282504

CHEMBL282504
pIC50 7.20

Structure of CHEMBL18295

CHEMBL18295
pIC50 7.22

Gene RIF (5)

AA Sequence 

MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQR      1 - 70
VSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVT     71 - 140
KKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVA    141 - 210
KAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVE    211 - 280
AVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQ    281 - 350
NVKVIDKTLVRKNPLAVSKI                                                      351 - 370
//

Text Mined References (17)

PMID Year Title