Tbio H6PD GDH/6PGL endoplasmic bifunctional protein

Protein Summary

Description

Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates. There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95479
• Q4TT33
• Q66I35
• Q68DT3

Gene Name

• H6PD

Ensembl ID

• ENST00000377403
• ENSP00000366620
• ENSG00000049239

Symbol

• GDH
• GDH
• G6PDH
• CORTRD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.88
disease perturbation	0.87
transcription factor binding site profile	0.82
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Gdh/6pgl Endoplasmic Bifunctional Protein

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Gdh/6pgl Endoplasmic Bifunctional Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.1   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 282   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 286.1   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0