Tbio GYPC Glycophorin-C

Protein Summary

Description

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• P04921
• B2R522
• Q53SV9
• Q92642

Gene Name

• GYPC

Ensembl ID

• ENST00000259254
• ENSP00000259254
• ENSG00000136732
• ENST00000356887
• ENSP00000349354
• ENST00000409836
• ENSP00000386904

Symbol

• GLPC
• GPC
• GE
• GPC
• GPD
• GYPD
• CD236
• PAS-2
• CD236R
• PAS-2'
• GE:GPC:GPD:GYPD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.71
transcription factor	0.68
transcription factor binding site profile	0.67
gene perturbation	0.66
PubMedID	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.27   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 435   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.27   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0