Property Summary

NCBI Gene PubMed Count 20
PubMed Score 61.33
PubTator Score 28.40

Knowledge Summary


No data available


  Disease (2)


  Differential Expression (3)

Disease log2 FC p
colon cancer -2.600 1.5e-05
active Crohn's disease -3.487 2.7e-03
ulcerative colitis -4.700 2.8e-09

Gene RIF (10)

26362536 HIV-1 Gag interacts with GUCA2A as demonstrated by proximity dependent biotinylation proteomics
25899674 In summary the structural analysis of missense SNPs is important to decrease the number of potential mutations to be in vitro evaluated for associating them with some genetic diseases
20213926 The myristoylated wild-type GCAP1 was found to have the highest Ca(2+) affinity and thermal stability.
19742348 There is differential expression of guanylin in colorectal cancer, and the differential expression is associated with tumor stage.
15901896 Guanylin plays a role in the regulation of ion transport in the colon
15780094 human cortical collecting duct cells are depolarized by guanylin.
14988827 It is likely that gallbladder epithelial cells synthesize and release guanylin into the bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway.
12707255 hormone prosequence interactions provide an explanation for the negligible bioactivity of the prohormone as well as the important role of the NH2-terminal residues in the disulfide-coupled folding of proguanylin
12463760 Results from circular dichroism and NMR spectroscopy validate native and recombinant proguanylin to be well-structured proteins adopting identical secondary structures and three-dimensional folds.
12163390 guanylin as a significant marker in salivary gland tumor pathology

AA Sequence


Text Mined References (21)

PMID Year Title
25899674 2015 Computational analyses and prediction of guanylin deleterious SNPs.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
20213926 2010 Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.
19742348 2009 [Differential expression of guanylin in colorectal cancer].
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15901896 2005 Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells.
15780094 2005 Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts.
14988827 2004 Guanylin regulates chloride secretion in the human gallbladder via the bile fluid.
12707255 2003 Solution structure of human proguanylin: the role of a hormone prosequence.
12463760 2002 Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution.
12163390 2002 Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains.
11889121 2002 Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells.
10601865 2000 Homologous desensitization of the human guanylate cyclase C receptor. Cell-specific regulation of catalytic activity.
9272623 1997 Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer.
8095028 1993 The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa).
7947768 1994 Determination of the solution structure of the peptide hormone guanylin: observation of a novel form of topological stereoisomerism.
7892222 1995 Analysis of the human guanylin gene and the processing and cellular localization of the peptide.
7601480 1995 Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.
7566098 1995 Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
1409606 1992 Precursor structure, expression, and tissue distribution of human guanylin.
1327879 1992 Human guanylin: cDNA isolation, structure, and activity.