| Tbio | Guanylyl cyclase-activating protein 2 |
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| RETINITIS PIGMENTOSA 48 | 1 | 0.0 | 0.0 |
| Retinitis Pigmentosa | 226 | 0.0 | 4.0 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.3e-06 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cone dystrophy | 71 | 5.246 | 2.6 |
| Retinal Degeneration | 106 | 4.36 | 2.2 |
| Partial central choroid dystrophy | 11 | 4.047 | 2.0 |
| Leber congenital amaurosis | 69 | 3.977 | 2.0 |
| Fundus dystrophy | 83 | 3.848 | 1.9 |
