Property Summary

NCBI Gene PubMed Count 26
PubMed Score 25.71
PubTator Score 12.31

Knowledge Summary


No data available


  Differential Expression (24)

Gene RIF (10)

26209226 Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients.
23236459 GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
22292647 GTSE1 is overexpressed dramatically in lung cancer patients' tissues.
20800603 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20577264 Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization.
20018861 hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel.
19913121 Observational study of gene-disease association. (HuGE Navigator)
14707141 requires an intact nuclear export signal and functional Mdm2 for the regulation of p53
12750368 GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function

AA Sequence

LIQLSPEADKENVDSPLLKF                                                      701 - 720

Text Mined References (33)

PMID Year Title
26209226 2015 GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells.
23236459 2012 GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22292647 2011 Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer.
20800603 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20577264 2010 Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20018861 2010 Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment.
19946888 2010 Defining the membrane proteome of NK cells.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18220336 2008 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
16964243 2006 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15998911 2005 Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays.
15790807 2005 Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15461802 2004 A genome annotation-driven approach to cloning the human ORFeome.
15302935 2004 Large-scale characterization of HeLa cell nuclear phosphoproteins.
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14707141 2004 hGTSE-1 expression stimulates cytoplasmic localization of p53.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12750368 2003 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10984615 2000 Cell-cycle regulation of the p53-inducible gene B99.
10974554 2000 Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene.
10591208 1999 The DNA sequence of human chromosome 22.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.