| Tbio | Transcription initiation factor IIB |
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 6.6e-06 |
| dermatomyositis | 966 | 1.9e-04 |
| lung cancer | 4740 | 2.1e-04 |
| Multiple myeloma | 1332 | 1.3e-03 |
| diabetes mellitus | 1728 | 1.4e-03 |
| osteosarcoma | 7950 | 2.6e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Xeroderma pigmentosum group B | 20 | 4.947 | 2.5 |
| Cockayne syndrome | 60 | 3.1 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| dermatomyositis | 1.300 | 1.9e-04 |
| diabetes mellitus | -1.100 | 1.4e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 2.9e-02 |
| lung cancer | -1.100 | 2.1e-04 |
| Multiple myeloma | 1.637 | 1.3e-03 |
| osteosarcoma | -1.080 | 2.6e-03 |
| ovarian cancer | -1.300 | 6.6e-06 |
MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDS 1 - 70 QNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNN 71 - 140 LFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLIT 141 - 210 TGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGV 211 - 280 ADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL 281 - 316 //
