Tbio GTF2A1L TFIIA-alpha and beta-like factor

Protein Summary

Description

May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription. The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9UNN4
• B4DY14
• Q53FD9
• Q5D050

Gene Name

• GTF2A1L

Ensembl ID

• ENST00000403751
• ENSP00000384597
• ENSG00000242441
• ENST00000430487
• ENSP00000387896

Symbol

• ALF
• GTF2A1LF
• ALF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.61
cellular component	0.6
protein domain	0.58
cell type or tissue	0.49
biological process	0.46

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Tfiia-alpha And Beta-like Factor

Protein / Nucleic Acid Binding / Tfiia-alpha And Beta-like Factor

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Tfiia-alpha And Beta-like Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.52   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.52   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0